An Efficient Microwave Assisted Eco‐friendly Synthesis of 6‐Chloro‐3‐(3‐arylacryloyl)‐2‐methyl‐4‐phenylquinolines and their Conversion to 6‐Chloro‐3‐(1‐phenyl‐5‐aryl‐4,5‐dihydro‐1H‐pyrazol‐ 3‐yl)‐2‐methyl‐4‐phenylquinolines

Abstract

An eco-friendly basic alumina catalyzed protocol for the synthesis of some new quinolinyl chalcones has been developed by microwave assisted methods which in turn are converted to pyrazoline derivatives.

Nickel oxide nanoparticles catalyzed synthesis of poly-substituted quinolines via Friedlander hetero-annulation reaction

“…Hydrochloric acid, sulfuric acid, p-toluenesulfonic acid 23 and PPA have been employed as catalysts for this conversion 24 [9][10][11][12]. Some of the methods reported for the synthesis of 25 quinolines also involve the use of catalysts such as SnCl 2 , BiCl 3 , 26 I 2 [12,13], montmorillonite KSF clay [14], ionic liquids [15], 27…”

“…Thus, a simple and environmentally benign 34 procedure with an inexpensive and readily available reagent is 35 desirable, which prompted us to test the feasibility of NiO 36 nanoparticles (NiO NPs) as a catalyst for the synthesis of quinolines 37 without any co-catalysts or additives. Hence in continuation of our 38 earlier effort on quinolines [25][26][27][28][29][30][31][32][33] The synthesized NiO NPs were characterized using an XRD 77…”

1-[3-(2-Methyl-4-phenylquinolin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-propane-1-one

“…Quinoline and its derivatives have been widely found in natural products and synthetic pharmaceuticals, which are associated with a broad spectrum of biological activities [1][2][3][4][5]. On the other hand, pyrazolines are important nitrogen-containing five-membered heterocyclic compounds, and their derivatives have been found to possess a broad spectrum of biological activities, such as antimalarial, antitrypanosomal, antitumor, and antidepressant activities [6][7][8][9][10][11]. The coupling of this chemical entity with a quinoline unit might be considered to have some biological activities.…”