An Efficient, Microwave Assisted Solvent‐Free Synthesis of Polarized Enamines.

Abstract

Microwave chemistry O 0170 An Efficient, Microwave Assisted Solvent-Free Synthesis of Polarized Enamines. -This newly found method is reported to be solvent-free, environmentally friendly, to have short reaction times and to give good to excellent yields. -(CHANDA, K.; DUTTA, M. C.; KARIM, E.; VISHWAKARMA*, J. N.; J. Indian Chem. Soc. 81 (2004) 9, 791-793; Org. Res. Lab.,

Synthesis of Novel Bis-enaminones by KHSO4-assisted Facile Michael Addition-elimination Reaction of 3-(dimethylamino)-1-phenylprop-2-en-1-ones with Diamines in Water

“…The IR spectra were recorded on a Perkin-Elmer 983 spectrometer. 1 H NMR and 13 C NMR spectra were recorded on Bruker ACF-300 spectrometer. The chemical shifts (δ ppm) and the coupling constants (Hz) are reported in the standard fashion with reference to TMS as internal reference.…”

“…Elemental analyses were performed on a Vario-EL III instrument. Formylated acetophenones 1a-e were synthesized by our previously reported procedure [13].…”

“…Keeping in view the synthetic potential of 3-(dimethylamino)-1-phenylprop-2-en-1-ones (formylated acetophenones) [2][3][4][5][6][7][8][9][10][11][12], we recently reported an efficient method for the formylation of active proton compounds [13]. We subsequently developed a facile synthetic strategy for the synthesis of enaminones by reacting formylated acetophenones with primary amines [14].…”

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,5-diarylpyrazole derivatives

“…The enaminone derivatives (8a-d) were prepared via condensation of the appropriate aryl or heteroaryl methyl ketone with dimethylformamide dimethylacetal (DMFDMA) in xylene following procedures applied in literatures [15][16][17][18][19][20][21] . Cyclocondensation of the appropriate enaminone (8a-d) with 4-hydrazinylbenzenesulfonamide hydrochloride (9a) 22 , methanesulfonylphenylhydrazine hydrochloride (9b) 23,24 or 4-hydrazinobenzoic acid (9c) 25 in aqueous ethanol afforded the respective 1,5-diarylpyrazoles (10a-l) in good yields (56-88%) (Scheme 1).…”

“…Silica gel column chromatography was performed using Merck silica gel 60 ASTM (70-230 mesh). Compounds 8a-d [15][16][17][18][19][20][21] , 9a-c [22][23][24][25] were prepared according to the reported procedures.…”