An efficient microwave assisted synthesis and antimicrobial activity of novel p‐Tolyloxyquinoline‐Triazole hybrid derivatives

Vishnuvardhan, M.V.P.S.; Pradeep, M.; Thalari, Gangadhar

doi:10.1016/j.cdc.2020.100612

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…Vishnuvardhan et al [ 30 ] synthesized a library of triazole-quinoline hybrids and studied their antimicrobial properties. The reaction pathway involves a typical click cyclocondensation reaction of quinoline with a triple bond with aryl-azide derivatives, when the corresponding triazole-quinoline hybrids 88a – l , Scheme 24 .…”

Section: Resultsmentioning

confidence: 99%

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

et al. 2022

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Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented.

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Section: Resultsmentioning

confidence: 99%

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

et al. 2022

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“…The process commenced with 2-( p-tolyloxy)quinoline-3-carbaldehyde and hydroxylacetophenes under µw irradiation conditions and the traditional method, as shown in Table 7, entry (18). 174 The µw-assisted approach proved simple, easy, and effective, necessitating a brief reaction time with significantly higher yields. An environment-friendly metal-free onepot µw-assisted synthesis of 4-aryl-1,4-dihydrochromene-triazoles by Alves et al using PEG-400 as the solvent in an ecofriendly procedure.…”

Section: Microwave-assisted Reactions (μW)mentioning

confidence: 99%

“…It encompasses one-pot synthesis involving aryl/alkyl halide, alkynes, and NaN 3 to produce 1,4-disubstituted 1,2,3-triazoles with exceptionally high yields and minimal by-products. 174 Several remarkable attempts have been undertaken to substantially reduce or eliminate the need for non-recyclable catalysts and solvents in organic compound synthesis. 175,176 The integration of µw technology has effectively controlled the utilization of expensive catalysts, hazardous reagents, and chlorinated solvents, enabling reactions to proceed immensely in solvent-less and catalyst-free conditions.…”

Section: Microwave-assisted Reactions (μW)mentioning

confidence: 99%

Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach

Kumar,

Lal,

Tittal

2024

Green Chem.

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“…The synthesis of a series of quinoline-based chalcone hybrids, 57a – 57l ( Figure 20 ), was reported by Vishnuvardhan et al (2021) [ 97 ]. The influence of different catalysts and solvents, as well as the use of conventional methods and MW heating for the CuAAC reaction was also presented, with maximum yield and lower time for the reaction carried under MW irradiation in the presence of CuI in DMF/water.…”

Section: 123-triazole-linked Flavonoid Hybrids With Antimicrobial Activitymentioning

confidence: 99%

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

et al. 2021

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As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed. Since the triazole ring has been associated with several biological activities and metabolic stability, hybridization with a 1,2,3-triazole ring has been increasingly reported over the last years. The feasible synthesis through copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) has allowed the accomplishment of several hybrids. Since 2017, almost 700 flavonoid hybrids conjugated with 1,2,3-triazole, including chalcones, flavones, flavanones and flavonols, among others, with antitumor, antimicrobial, antidiabetic, neuroprotective, anti-inflammatory, antioxidant, and antifouling activity have been reported. This review compiles the biological activities recently described for these hybrids, highlighting the mechanism of action and structure–activity relationship (SAR) studies.

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An efficient microwave assisted synthesis and antimicrobial activity of novel p‐Tolyloxyquinoline‐Triazole hybrid derivatives

Cited by 8 publications

References 21 publications

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

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