An efficient S-NO-polysilsesquioxane nano-platform for the co-delivery of nitric oxide and an anticancer drug

Wang, Meng Ren; Chiu, Shih Jiuan; Chou, Hung Chang; Hu, Teh Min

doi:10.1039/c5cc06087g

Cited by 24 publications

(18 citation statements)

References 23 publications

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“…The hydrodynamic diameter of the material is fairly constant over a period of 24 h, and minimal degradation was observed during 192 h as an indication of its colloidal and chemical stability (Figure S1B-C). As reported previously, PSilQ nanomaterials are distinguished for reaching a high loading capacity of the therapeutic agent [9,[27][28][29]; in this case, the loading of PpIX to PSilQ nanoparticles was determined to be 24.0 ± 4.0%wt.…”

Section: Discussionsupporting

confidence: 61%

Light-Activated Protoporphyrin IX-Based Polysilsesquioxane Nanoparticles Induce Ferroptosis in Melanoma Cells

et al. 2021

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The use of nanoparticle-based materials to improve the efficacy of photodynamic therapy (PDT) to treat cancer has been a burgeoning field of research in recent years. Polysilsesquioxane (PSilQ) nanoparticles with remarkable features, such as high loading of photosensitizers, biodegradability, surface tunability, and biocompatibility, have been used for the treatment of cancer in vitro and in vivo using PDT. The PSilQ platform typically shows an enhanced PDT performance following a cell death mechanism similar to the parent photosensitizer. Ferroptosis is a new cell death mechanism recently associated with PDT that has not been investigated using PSilQ nanoparticles. Herein, we synthesized a protoporphyrin IX (PpIX)-based PSilQ platform (PpIX-PSilQ NPs) to study the cell death pathways, with special focus on ferroptosis, during PDT in vitro. Our data obtained from different assays that analyzed Annexin V binding, glutathione peroxidase activity, and lipid peroxidation demonstrate that the cell death in PDT using PpIX-PSilQ NPs is regulated by apoptosis and ferroptosis. These results can provide alternative approaches in designing PDT strategies to enhance therapeutic response in conditions stymied by apoptosis resistance.

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Section: Discussionsupporting

confidence: 61%

Light-Activated Protoporphyrin IX-Based Polysilsesquioxane Nanoparticles Induce Ferroptosis in Melanoma Cells

et al. 2021

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“…The positive effect of NO was attributed to a potential improvement of circulation of cisplatin since NO could bind to sites such as thiols that might attach to platinum and by so doing lower the cisplatin chemotherapeutic effect . Note that, another study capitalized on the codelivery of NO with doxorubicin drugs via polysilsesquioxane nanovectors against breast cancer cells …”

Section: Trends In Biomedical Applicationsmentioning

confidence: 99%

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant

Fatieiev

Almalik

et al. 2017

Adv Healthcare Materials

474

349

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Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.

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“…They devised a simple one-step nanoprecipitation/drug entrapment procedure to prepare nanoparticles containing S -nitrosothiol and DOX [67]. SNO-polysilsesquioxane was synthesized by acid-catalyzed polycondensation of 3-mercaptopropyltrimethoxysilane (MPTMS) in the presence of sodium nitrite in organic solution.…”

Section: Progress Of Combined No and Drug Delivery Systemsmentioning

confidence: 99%

Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

Kim

Yung

Kim

et al. 2017

Journal of Controlled Release

173

119

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Chemotherapeutic drugs have made significant contributions to anticancer therapy, along with other therapeutic methods including surgery and radiotherapy over the past century. However, multidrug resistance (MDR) of cancer cells has remained as a significant obstacle in the achievement of efficient chemotherapy. Recently, there has been increasing evidence for the potential function of nitric oxide (NO) to overcome MDR. NO is an endogenous and biocompatible molecule, contrasting with other potentially toxic chemosensitizing agents that reverse MDR effects, which has raised expectations in the development of efficient therapeutics with low side effects. In particular, nanoparticle-based drug delivery systems not only facilitate the delivery of multiple therapeutic agents, but also help bypass MDR pathways, which are conducive for the efficient delivery of NO and anticancer drugs, simultaneously. Therefore, this review will discuss the mechanism of nitric oxide (NO) in overcoming MDR and recent progress of combined NO and drug delivery systems.

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An efficient S-NO-polysilsesquioxane nano-platform for the co-delivery of nitric oxide and an anticancer drug

Cited by 24 publications

References 23 publications

Light-Activated Protoporphyrin IX-Based Polysilsesquioxane Nanoparticles Induce Ferroptosis in Melanoma Cells

Light-Activated Protoporphyrin IX-Based Polysilsesquioxane Nanoparticles Induce Ferroptosis in Melanoma Cells

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

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