An efficient tumor-inducible nanotheranostics for magnetic resonance imaging and enhanced photodynamic therapy

Zhu, Wei; Zhang, L.; Yang, Zhe; Liu, Pei; Wang, Jing; Cao, Jinguo; Shen, Aiguo; Xu, Zushun

doi:10.1016/j.cej.2018.10.102

Cited by 50 publications

(15 citation statements)

References 43 publications

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“…Among in vitro cytotoxicity tests, MTT [58,[61][62][63][64][65], the alamarBlue ® cell viability assay [54,66], and CCK-8 [67], are the most widely used with MOFs. Table 1 includes a list of cytotoxicity tests performed with neat MOFs so far, resulting in adequate cytotoxicity values [54,[58][59][60][61]63,65,[67][68][69][70]. These results support the fact that it results safe the use of relatively high concentrations of these MOFs aqueous suspensions.…”

Section: Evaluation Of Mofs Toxicitymentioning

confidence: 58%

Metal-Organic Frameworks in Green Analytical Chemistry

et al. 2019

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Metal-organic frameworks (MOFs) are porous hybrid materials composed of metal ions and organic linkers, characterized by their crystallinity and by the highest known surface areas. MOFs structures present accessible cages, tunnels and modifiable pores, together with adequate mechanical and thermal stability. Their outstanding properties have led to their recognition as revolutionary materials in recent years. Analytical chemistry has also benefited from the potential of MOF applications. MOFs succeed as sorbent materials in extraction and microextraction procedures, as sensors, and as stationary or pseudo-stationary phases in chromatographic systems. To date, around 100 different MOFs form part of those analytical applications. This review intends to give an overview on the use of MOFs in analytical chemistry in recent years (2017–2019) within the framework of green analytical chemistry requirements, with a particular emphasis on possible toxicity issues of neat MOFs and trends to ensure green approaches in their preparation.

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Section: Evaluation Of Mofs Toxicitymentioning

confidence: 58%

Metal-Organic Frameworks in Green Analytical Chemistry

et al. 2019

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“…4T1 cells (1 × 10 6 ) were first seeded and cultured at 37 °C overnight, followed by incubating with (1) PBS, (2) blank, and different concentrations of (3) APZ, (4) PCZ, (5) PCZ and (6) APCZ, respectively. After co-culturing for 12 h, group (5) and (6) were irradiated by 1064 nm laser (1 W cm −1 , 10 min) and then underwent incubation for another 12 h. Cell viabilities were determined using a standard MTT assay [ 31 ]. Likewise, group (4), (5) and (6) were conducted once more in a hypoxic atmosphere (1% O 2 ).…”

Section: Methodsmentioning

confidence: 99%

NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy

et al. 2021

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Background Though the combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) appears to be very attractive in cancer treatment, hypoxia and overproduced glutathione (GSH) in the tumor microenvironment (TME) limit their efficacy for further application. Results In this work, a smart hypoxia-irrelevant free radical nanogenerator (AIPH/PDA@CuS/ZIF-8, denoted as APCZ) was synthesized in situ via coating copper sulphide (CuS)-embedded zeolitic imidazolate framework-8 (ZIF-8) on the free radical initiator 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH)-loaded polydopamine (PDA). APCZ showed promising GSH-depleting ability and near-infrared (NIR)-II photothermal performance for combined cancer therapy. Once internalized by 4T1 cells, the outer ZIF-8 was rapidly degraded to trigger the release of CuS nanoparticles (NPs), which could react with local GSH and sequentially hydrogen peroxide (H2O2) to form hydroxyl radical (·OH) for CDT. More importantly, the hyperthermia generated by APCZ upon 1064 nm laser excitation not only permitted NIR-II photothermal therapy (PTT) and promoted CDT, but also triggered the decomposition of AIPH to give toxic alkyl radical (·R) for oxygen-independent PDT. Besides, the PDA together with CuS greatly decreased the GSH level and resulted in significantly enhanced PDT/CDT in both normoxic and hypoxic conditions. The tumors could be completely eradicated after 14 days of treatment due to the prominent therapeutic effects of PTT/PDT/CDT. Additionally, the feasibility of APCZ as a photoacoustic (PA) imaging contrast agent was also demonstrated. Conclusions The novel APCZ could realize the cooperative amplification effect of free radicals-based therapies by NIR-II light excitation and GSH consumption, and act as a contrast agent to improve PA imaging, holding tremendous potential for efficient diagnosis and treatment of deep-seated and hypoxic tumors. Graphic abstract

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“…In order to endow the specificity of nanoparticles for targeting tumors to enhance PDT, as reported by He, the AS1411 aptamer was anchored to the surface of large pore silica nanoparticles in which MnO 2 nanoparticles were grown in situ 107. Zhu et al constructed a multifunctional therapeutic nanoplatform through the integration of the nanoscale metal-organic framework (NMOF), BSA, sulfadiazines (SDs), and MnO 2 into a system 108. Porphyrins not only participate in the formation of NMOF as organic ligands but also act as photosensitizers.…”

Section: Mno2-based Nanoparticles In Tumor Diagnosis and Therapymentioning

confidence: 99%

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

Cai¹,

Zhu²,

Zeng³

et al. 2019

IJN

188

118

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Contrast agents (CAs) play a crucial role in high-quality magnetic resonance imaging (MRI) applications. At present, as a result of the Gd-based CAs which are associated with renal fibrosis as well as the inherent dark imaging characteristics of superparamagnetic iron oxide nanoparticles, Mn-based CAs which have a good biocompatibility and bright images are considered ideal for MRI. In addition, manganese oxide nanoparticles (MONs, such as MnO, MnO2, Mn3O4, and MnOx) have attracted attention as T1-weighted magnetic resonance CAs due to the short circulation time of Mn(II) ion chelate and the size-controlled circulation time of colloidal nanoparticles. In this review, recent advances in the use of MONs as MRI contrast agents for tumor detection and diagnosis are reported, as are the advances in in vivo toxicity, distribution and tumor microenvironment-responsive enhanced tumor chemotherapy and radiotherapy as well as photothermal and photodynamic therapies.

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An efficient tumor-inducible nanotheranostics for magnetic resonance imaging and enhanced photodynamic therapy

Cited by 50 publications

References 43 publications

Metal-Organic Frameworks in Green Analytical Chemistry

Metal-Organic Frameworks in Green Analytical Chemistry

NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

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