An Efficient Ultrasound-assisted Method for the Synthesis of 1,4-Disubstituted Triazoles

Abstract

An efficient method for the synthesis of 1,4-disubstituted triazoles has been developed with the help of ultrasound irradiation in water at room temperature. Under the optimized conditions, a novel series of 1,4-disubstituted 1,2,3-triazoles was synthesized in high yields.

Ligand Synthesis Catalyst and Complex Metal Ion: Multicomponent Synthesis of 1,3-Bis(4-phenyl-[1,2,3]triazol-1-yl)-propan-2-ol Copper(I) Complex and Application in Copper-Catalyzed Alkyne-Azide Cycloaddition

“…)-1,2,3-triazole(9). 1-Chloro-4-prop-2-ynyloxy-benzene and benzyl azide afforded 1-benzyl-4-(4-chlorophenoxymethyl)-1,2,3-triazole as white solid.…”