An effort to test the embryotoxicity of benzene, toluene, xylene, and formaldehyde to murine embryonic stem cells using airborne exposure technique

Shen, Shuijie; Yuan, Lingmin; Zeng, Su

doi:10.1080/08958370802687493

Cited by 13 publications

(5 citation statements)

References 28 publications

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“…In humans, increased Th2 polarisation of neonatal immune responses has been associated with maternal VOC exposure during pregnancy [82]. Although little evidence exists suggesting that VOCs influence lung growth, embryotoxic effects from exposure to airborne VOCs on murine embryonic stem cells have been reported [83], and adverse effects on rat embryo/fetal development have been linked to VOC release from their cages [84].…”

Section: Discussionmentioning

confidence: 99%

Volatile organic compounds and risk of asthma and allergy: a systematic review

et al. 2015

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Volatile organic compounds (VOCs) are ubiquitous domestic pollutants. Their role in asthma/allergy development and exacerbations is uncertain. This systematic review investigated whether domestic VOC exposure increases the risk of developing and/or exacerbating asthma and allergic disorders.We systematically searched 11 databases and three trial repositories, and contacted an international panel of experts to identify published and unpublished experimental and epidemiological studies.8455 potentially relevant studies were identified; 852 papers were removed after de-duplication, leaving 7603 unique papers that were screened. Of these, 278 were reviewed in detail and 53 satisfied the inclusion criteria. Critical appraisal of the included studies indicated an overall lack of high-quality evidence and substantial risk of bias in this body of knowledge. Aromatics (i.e. benzenes, toluenes and xylenes) and formaldehyde were the main VOC classes studied, both in relation to the development and exacerbations of asthma and allergy. Approximately equal numbers of studies reported that exposure increased risks and that exposure was not associated with any detrimental effects.The available evidence implicating domestic VOC exposure in the risk of developing and/or exacerbating asthma and allergy is of poor quality and inconsistent. Prospective, preferably experimental studies, investigating the impact of reducing/eliminating exposure to VOC, are now needed in order to generate a more definitive evidence base to inform policy and clinical deliberations in relation to the management of the now substantial sections of the population who are either at risk of developing asthma/ allergy or living with established disease. @ERSpublications Investigation of VOCs in relation to developing or exacerbating asthma or allergy indicates new studies are required

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Section: Discussionmentioning

confidence: 99%

Volatile organic compounds and risk of asthma and allergy: a systematic review

et al. 2015

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“…High exposure to xylene may be observed in histopathological laboratory technicians especially during the deparaffinization of tissue sections [ 3 ]. The organ systems that are most susceptible to xylene are the lungs, skin, central nervous system, liver, and kidneys [ 4 ]. Many studies have also shown adverse effects of xylene on human and animal reproduction.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Flaxseed (Linum usitatissimum L.) Alters Ovarian Functions of Xylene-Exposed Mice

Vlčková

Andrejčáková

Lecová

et al. 2022

Life

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The aim of the performed study was to examine the ability of xylene, flaxseed, and their combinations to affect morphological and endocrine indexes of murine ovaries. The 72 indexes of secondary and tertiary follicular cells, oocytes, corpora lutea, and ovarian stroma have been quantified: diameter, markers of proliferation PCNA and apoptosis caspase 3, receptors to FSH, oxytocin, estrogen (alpha and beta), and progesterone. In addition, concentrations of the ovarian hormones progesterone, estradiol, and IGF-I in the blood, as well as their production by isolated ovaries cultured with and without gonadotropins (FSH + LH mixture), were determined using histological, immunohistochemical, and immunoassay analyses. The character of xylene and flaxseed effects on ovarian functions in mice depended on the stage of ovarian folliculogenesis. It was shown that flaxseed could mitigate and prevent the major (63%) effects of xylene on the ovary. In addition, the ability of gonadotropins to affect ovarian hormone release and prevent its response to xylene has been shown. The effects of these additives could be mediated by changes in the release and reception of hormones. These observations suggest that flaxseed and possibly gonadotropins could be natural protectors of a female reproductive system against the adverse effects of xylene.

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“…12,13 Previous studies have found that HCHO and BTX exposure has negative effects on the reproductive, immune, cardiovascular and respiratory, and can cause blood system disorders and leukaemia. [32][33][34][35][36][37] Researchers found that different genders and age groups have different sensitivity to pollutants. 38,39 A number of studies have shown that refurnished residences can cause rhinitis, eyes and skin diseases, asthma and leukaemia, especially in children and women.…”

Section: Introductionmentioning

confidence: 99%

Variations of HCHO and BTX, human health risk and indoor renovation characteristics of newly renovated rental apartments in Beijing, China

Zhang

Wang

et al. 2021

Indoor and Built Environment

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The popularity of decoration and refurbishment of rental apartments in China may give rise to indoor VOC levels, posing health threats to tenants. A questionnaire was conducted on the renovation characteristics and tenant information of rental apartments in Beijing. The study selected 143 rental bedrooms to study the characteristics of HCHO and BTX (benzene, toluene and xylene) and assessed the health risks of tenants. The results showed that the median of HCHO concentration was 0.07 mg/m3, within one to three months of renovation. The concentration declined to 0.03 mg/m3 after one year. However, BTX concentration was increased by four times after one year of renovation, probably due to tenants’ move-in. The mean of inhalation lifetime cancer risk for HCHO and benzene was calculated as 1.15–3.63 (10−5) and 2.46–7.9 (10−5), respectively, indicating probable risk. The tenants’ health risks were: infant > teenager > adult and male > female. Benzene in rental homes posed the greater health risk to humans than previous studies conducted in ordinary residences. The results show that 45.29% of rental apartments are renovated before the new tenants move in, and 86.27% of tenants have a lease length of less than three years. These behaviours may cause exacerbation of pollutant levels in rental apartments.

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An effort to test the embryotoxicity of benzene, toluene, xylene, and formaldehyde to murine embryonic stem cells using airborne exposure technique

Cited by 13 publications

References 28 publications

Volatile organic compounds and risk of asthma and allergy: a systematic review

Volatile organic compounds and risk of asthma and allergy: a systematic review

Dietary Supplementation of Flaxseed (Linum usitatissimum L.) Alters Ovarian Functions of Xylene-Exposed Mice

Variations of HCHO and BTX, human health risk and indoor renovation characteristics of newly renovated rental apartments in Beijing, China

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