An Electrochemical Aptasensor for Pb2+ Detection Based on Metal–Organic-Framework-Derived Hybrid Carbon

Ding, Jingtao; Zhang, Dongwei; Liu, Yang; Zhan, Xuejia; Lu, Yitong; Zhou, Pei; Zhang, Dan

doi:10.3390/bios11010001

Cited by 24 publications

(5 citation statements)

References 55 publications

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“…Guanine rich oligonucleotides favor detection of Pb 2+ by forming a G-quadruplex structure with high specificity. This structure exhibits good stability even with interference from other metal ions [56].…”

Section: Pb 2+ Detectionmentioning

confidence: 97%

Aptamer functionalized ZnO thin-film transistor based multiplexed detection of Lead and E. coli in water

Honnali

Ragha

Ashwath

et al. 2022

Preprint

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Background: Contamination of lead (Pb 2+) disturbs biological functions and causes neurotoxicity even at low levels. Pathogens such as Escherichia coli, P. aeruginosa and S. aureus found in packaged drinking water causes infections. Therefore, we demonstrate the multiplexed detection of Pb 2+ and E. coli in water using ZnO thin-film transistor (TFT) arrays. Results: Low voltage ZnO TFTs fabricated by physical vapour deposition were functionalized with APTES-glutaraldehyde molecules. TFTs with such functionalized ZnO surfaces showed good sensitivity and high specificity to the targets. The TFTs showed a detection limit of 27 nM and 10 5 cfu/ml for Pb 2+ and E. coli, respectively with the TFT flat-band voltage (V fb), and hence the TFT transconductance, being dependent on the target concentration. The direct integration of the sensing with the TFT and associated integrated circuits promises high density sensor arrays.Conclusion: The present work highlights the importance of aptamers in the multiplexed detection of different targets using low cost ZnO TFT array.

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Section: Pb 2+ Detectionmentioning

confidence: 97%

Aptamer functionalized ZnO thin-film transistor based multiplexed detection of Lead and E. coli in water

Honnali

Ragha

Ashwath

et al. 2022

Preprint

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“…The current increases with Pb 2+ concentration. The findings demonstrated a solid linear association between the Pb 2+ concentration and the range of 0.1 to 10 ugL −1 with a detection limit of 0.096 ugL −1 [ 65 ].…”

Section: Electrochemical Biosensor Detection Of Heavy Metalsmentioning

confidence: 99%

“…( b ) Presentation diagram of the preparation process for the aptasensor and Pb 2+ detection, SEM image and TEM image of ZIF-8@ZIF-67 [ 65 ]. Reprinted with permission [ 65 ]. Copyright 2020, Biosensors.…”

Section: Figures and Schemementioning

confidence: 99%

Recent Advances in the Application of Bionanosensors for the Analysis of Heavy Metals in Aquatic Environments

Wu,

Ga,

Wang

et al. 2023

Molecules

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Heavy-metal ions (HMIs) as a pollutant, if not properly processed, used, and disposed of, will not only have an influence on the ecological environment but also pose significant health hazards to humans, making them a primary factor that endangers human health and harms the environment. Heavy metals come from a variety of sources, the most common of which are agriculture, industry, and sewerage. As a result, there is an urgent demand for portable, low-cost, and effective analytical tools. Bionanosensors have been rapidly developed in recent years due to their advantages of speed, mobility, and high sensitivity. To accomplish effective HMI pollution control, it is important not only to precisely pinpoint the source and content of pollution but also to perform real-time and speedy in situ detection of its composition. This study summarizes heavy-metal-ion (HMI) sensing research advances over the last five years (2019–2023), describing and analyzing major examples of electrochemical and optical bionanosensors for Hg2+, Cu2+, Pb2+, Cd2+, Cr6+, and Zn2+.

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“…The aptamers were able to recognize Pb 2+ and measure the cyclic voltammetry. Furthermore, this aptasensor exhibited reproducibility and practicability; however, high concentrations of Ag + , K +, and NH 4+ caused interferences in the performances suggesting that further research should be performed in order to avoid such effects [ 35 ].…”

Section: Recent Advances In Aptamer-based Biosensorsmentioning

confidence: 99%

Detection of Emerging Pollutants Using Aptamer-Based Biosensors: Recent Advances, Challenges, and Outlook

et al. 2022

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The synergistic potentialities of innovative materials that include aptamers have opened new paradigms in biosensing platforms for high-throughput monitoring systems. The available nucleobase functional moieties in aptamers offer exclusive features for bioanalytical sensing applications. In this context, compared to various in-practice biological recognition elements, the utilization of aptamers in detection platforms results in an extensive range of advantages in terms of design flexibility, stability, and sensitivity, among other attributes. Thus, the utilization of aptamers-based biosensing platforms is extensively anticipated to meet unaddressed challenges of various in-practice and standard analytical and sensing techniques. Furthermore, the superior characteristics of aptasensors have led to their applicability in the detection of harmful pollutants present in ever-increasing concentrations in different environmental matrices and water bodies, seeking to achieve simple and real-time monitoring. Considering the above-mentioned critiques and notable functional attributes of aptamers, herein, we reviewed aptamers as a fascinating interface to design, develop, and deploy a new generation of monitoring systems to aid modern bioanalytical sensing applications. Moreover, this review aims to summarize the most recent advances in the development and application of aptasensors for the detection of various emerging pollutants (EPs), e.g., pharmaceutical, and personal care products (PPCPs), endocrine-disrupting chemicals (EDCs), pesticides and other agricultural-related compounds, and toxic heavy elements. In addition, the limitations and current challenges are also reviewed, considering the technical constraints and complexity of the environmental samples.

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An Electrochemical Aptasensor for Pb2+ Detection Based on Metal–Organic-Framework-Derived Hybrid Carbon

Cited by 24 publications

References 55 publications

Aptamer functionalized ZnO thin-film transistor based multiplexed detection of Lead and E. coli in water

Aptamer functionalized ZnO thin-film transistor based multiplexed detection of Lead and E. coli in water

Recent Advances in the Application of Bionanosensors for the Analysis of Heavy Metals in Aquatic Environments

Detection of Emerging Pollutants Using Aptamer-Based Biosensors: Recent Advances, Challenges, and Outlook

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