An electrochemical paper based nano-genosensor modified with reduced graphene oxide-gold nanostructure for determination of glycated hemoglobin in blood

Jaberi, Seyedeh Yasaman Shajaripour; Ghaffarinejad, Ali; Omidinia, Eskandar

doi:10.1016/j.aca.2019.06.018

Cited by 67 publications

(32 citation statements)

References 48 publications

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“…It has been highlighted that there is a pressing need for the development of a specific, sensitive, simple, accessible, yet economical diagnostic method. In this case, the development of paper-based biosensors have caught the attention of researchers owing to their idiosyncratic properties, accompanied by the portability of the device which can in turn, provide rapid analysis and data without the need to conduct in a laboratory [46].…”

Section: Methodology For Cytokine and Cancer Biomarkers Quantificationmentioning

confidence: 99%

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Loo

Pui

2020

Sensors

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Although the established ELISA-based sensing platforms have many benefits, the importance of cytokine and cancer biomarkers detection for point-of-care diagnostics has propelled the search for more specific, sensitive, simple, accessible, yet economical sensor. Paper-based biosensor holds promise for future in-situ applications and can provide rapid analysis and data without the need to conduct in a laboratory. Electrochemical detection plays a vital role in interpreting results obtained from qualitative assessment to quantitative determination. In this review, various factors affecting the design of an electrochemical paper-based biosensor are highlighted and discussed in depth. Different detection methods, along with the latest development in utilizing them in cytokine and cancer biomarkers detection, are reviewed. Lastly, the fabrication of portable electrochemical paper-based biosensor is ideal in deliberating positive societal implications in developing countries with limited resources and accessibility to healthcare services.

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Section: Methodology For Cytokine and Cancer Biomarkers Quantificationmentioning

confidence: 99%

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Loo

Pui

2020

Sensors

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“…Moreover, the fact that they still require to be implemented in controlled settings prevents the development of a portable and accessible POC with its full potential [ 95 , 96 , 97 ]. Electrochemical microfluidic devices for HbA1c determination have also been reported [ 44 , 98 , 99 ]. Specifically, electrochemical impedance spectroscopy (EIS) has attracted attention for being a non-destructive and very sensitive biosensing technique.…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…A nanobiosensor with a three-dimensional gold structure has also been documented for the determination of HbA1c in blood. Although it possesses the desirable characteristics of high sensitivity (269.2 mA/cm 2 ) and low detection limit (0.0068 mg/dL), the concentration of HbA1c in blood is above the linear range of the biosensor, requiring sample dilution [ 99 ]. Undoubtedly, the use of nanomaterials to develop paper-based devices with electrochemical detection has driven the advancement of HbA1c determination.…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

2021

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A point-of-care (POC) can be defined as an in vitro diagnostic test that can provide results within minutes. It has gained enormous attention as a promising tool for biomarkers detection and diagnosis, as well as for screening of chronic noncommunicable diseases such as diabetes mellitus. Diabetes mellitus type 2 is one of the metabolic disorders that has grown exponentially in recent years, becoming one of the greatest challenges to health systems. Early detection and accurate diagnosis of this disorder are essential to provide adequate treatments. However, efforts to reduce incidence should remain not only in these stages but in developing continuous monitoring strategies. Diabetes-monitoring tools must be accessible and affordable; thus, POC platforms are attractive, especially paper-based ones. Paper-based POCs are simple and portable, can use different matrixes, do not require highly trained staff, and are less expensive than other platforms. These advantages enhance the viability of its application in low-income countries and hard-to-reach zones. This review aims to present a critical summary of the main components required to create a sensitive and affordable enzymatic paper-based POC, as well as an oriented analysis to highlight the main limitations and challenges of current POC devices for diabetes type 2 monitoring and future research opportunities in the field.

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“…Graphene-based biosensors play a pivotal role in the sensing of incurable and fatal diseases, such as diabetes and various kinds of cancer. Jaberi et al developed an RGO–Au nanostructure paper-based electrochemical nano-genosensor for HbA1c determination on a flexible and cost-effective graphite sheet (GS) electrode [103]. A wide concentration of 1–13.83 μM could be successfully determined by the thiolated aptamer-based genosensor.…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

188

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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An electrochemical paper based nano-genosensor modified with reduced graphene oxide-gold nanostructure for determination of glycated hemoglobin in blood

Cited by 67 publications

References 48 publications

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

Nanomaterials for Healthcare Biosensing Applications

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