An electrokinetic supercharging approach for the enantiodetermination of cathinones in urine samples by capillary electrophoresis

Pérez‐Alcaraz, Albert; Borrull, Francesc; Aguilar, Carme; Calull, Marta

doi:10.1016/j.microc.2020.105300

Cited by 10 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combination of tITP with the electrokinetic sample injection is known as electrokinetic supercharging (EKS), which generally makes highly efficient enrichments possible. Recently, EKS has been employed to the determination of γ-aminobutyric acid [57], secbumeton [58], neurotransmitters [59], cathinones [60], and nucleosides [61]. As a biological application, Wells et al reported the sensitivity for neurotransmitters was improved 5000-fold by EKS, and the developed EKS method was successfully applied to the analysis of seven biogenic amines from rat brain stem and whole Drosophila tissue [59].…”

Section: Application Of Transient Isotachophoresismentioning

confidence: 99%

Recent Applications of Dynamic On-Line Sample Preconcentration Techniques in Capillary Electrophoresis

Kitagawa

SOMA

2022

Chromatography

View full text Add to dashboard Cite

This review highlights recent applications of on-line sample preconcentration techniques in capillary electrophoresis (CE) from 2019 to 2021. Various preconcentration techniques based on the analyte velocity change in two or three discontinuous solutions system including field-amplified sample stacking, transient isotachophoresis, pH-mediated stacking, sweeping, and their modified and combined techniques have been employed to enrich and separate biological, environmental, food samples, and so on, in CE. More than 60 published research articles collected from Scopus databases described the dynamic on-line sample preconcentration techniques. This review provides comprehensive tables listing the applications of the on-line sample preconcentration techniques.

show abstract

Section: Application Of Transient Isotachophoresismentioning

confidence: 99%

Recent Applications of Dynamic On-Line Sample Preconcentration Techniques in Capillary Electrophoresis

Kitagawa

SOMA

2022

Chromatography

View full text Add to dashboard Cite

show abstract

“…In this context, several publications referenced CE for the enantiomeric separation of SC using cyclodextrines as chiral selector [10][11][12][13][14][15]. Recently, several preconcentration strategies were evaluated in order to reach high sensitivity for the enantiodetermination of cathinones in urine samples [16,17]. This research group also proposed an in-line SPE with CE-MS analysis for the enantiodetermination of R,S-3,4-methylenedioxypyrovalerone [18].…”

Section: Introductionmentioning

confidence: 99%

Development of a sensitive MEKC‐LIF method for synthetic cathinones analysis

et al. 2021

View full text Add to dashboard Cite

Synthetic cathinones are phenylalkylamine compounds related to natural cathinone from Catha edulis leaves. Due to their sympathomimetic effects comparable to common illicit drugs, these substances are mainly drugs of abuse and constitute the second most frequently seized group of new psychoactive substances. In order to ensure their regulation and to promote public health, reliable analytical tools are required to track these substances. In the present study, we developed a CE hyphenated to laser-induced fluorescence detection method to demonstrate its suitability to perform fast and cost-effective synthetic cathinones analysis. Fourteen compounds including isobaric compounds and position isomers were selected to encompass the large panel of chemical structures. To separate the FITC-labeled analytes (presenting the same negative charge and close mass to charge ratios), MEKC separation mode was selected. Method selectivity was not suitable using common surfactants. In this context, alkyl polyethylene glycol ether surfactants were successfully used as neutral surfactant to overcome this analytical challenge. The effect of surfactant nature on separation performances and migration behaviors of the analytes was also studied. Optimal BGE composition included 75 mM borate buffer at pH 9.3 and 0.4 mM of C12E10 surfactant. Final MEKC separation conditions were proposed to analyze a large panel of synthetic cathinones. This method helped to reach a sensitivity with LOD from 0.1 to 0.4 nM (pg/mL order).

show abstract

“…This increase is mainly due to the similar euphoric effects of these cathinones, but lower prices and easier acquisition than amphetamines [1][2][3]. For this reason, the interest of the police and health authorities in the detection and determination of these substances has grown, as it is reflected in the emergence of extensive literature related to their analysis [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…This cathinone, which is a pyrrolidine derivative of pyrovalerone, acts as dopamine and norepinephrine reuptake inhibitor [3,19,20]. After producing the stimulating effect, the remaining compound is excreted from the body and can be found at low concentration levels in biological samples, such as urine, plasma or hair [6][7][8][9][10][11][12][13][14][15][16][17][18]. Therefore, the determination of MDPV in urine requires the use of high sensitive methods, and there are several examples in the literature that allow reaching the necessary levels, mainly based on gas chromatography (GC) [15][16][17][18] or liquid chromatography (LC) [10][11][12][13] with mass spectrometry (MS) or tandem MS detection.…”

Section: Introductionmentioning

confidence: 99%

Enantiodetermination of R,S-3,4-methylenedioxypyrovalerone in urine samples by high pressure in-line solid-phase extraction capillary electrophoresis-mass spectrometry

Pérez‐Alcaraz

Borrull

Aguilar

et al. 2021

Talanta

Self Cite

View full text Add to dashboard Cite

An electrokinetic supercharging approach for the enantiodetermination of cathinones in urine samples by capillary electrophoresis

Cited by 10 publications

References 35 publications

Recent Applications of Dynamic On-Line Sample Preconcentration Techniques in Capillary Electrophoresis

Recent Applications of Dynamic On-Line Sample Preconcentration Techniques in Capillary Electrophoresis

Development of a sensitive MEKC‐LIF method for synthetic cathinones analysis

Enantiodetermination of R,S-3,4-methylenedioxypyrovalerone in urine samples by high pressure in-line solid-phase extraction capillary electrophoresis-mass spectrometry

Contact Info

Product

Resources

About