An electron microscope study of ?Pacinian neurofibroma?

Weiser, G

doi:10.1007/bf00433892

Cited by 55 publications

(14 citation statements)

References 33 publications

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“…Tumors arising from a peripheral nerve sheath can contain these cells in various proportions, as found in many ultrastructural studies [9,15,18,25,32,36,37]. Moreover, some authors [9,15] have also observed additional cells that had ultrastructural features interpretable as transitional stages among the three main cell types.…”

Section: Discussionmentioning

confidence: 88%

A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers

et al. 2004

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We present six cases of a distinctive soft tissue tumor which occurred in five women and one man. None of the patients had signs of neurofibromatosis. All tumors occurred on the fingers ( n=5) or the thenar eminence of the hand ( n=1). The mean age of the patients was 33 years. The tumors were 1-2.5 cm in diameter (mean size 1.6 cm). Three patients with follow-up were without signs of recurrence or metastasis. Microscopically the lesions were nonencapsulated and featured a multilobular architecture and both myxoid and pseudocystic change. The lobules varied in size and shape and were separated by variably thickened, dense, sclerotic/collagenous septae. The lobules were composed of two components: schwannomatous and perineuriomatous. The schwannomatous component was immunohistochemically S-100 protein positive and CD34 and EMA negative, and the perineuriomatous component had the appearance of retiform perineurioma. The perineurial parts were mostly S-100 protein and CD34 negative and EMA positive. These two components either formed separate nodules or the schwannomatous tissue surrounded the perineurial parts located in the centers of the lobules. We interpreted the lesions as hybrid tumors with features of schwannoma and retiform perineurioma.

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Section: Discussionmentioning

confidence: 88%

A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers

et al. 2004

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“…In order to establish this, it would be of interest to investigate cases of Pacinian neurofibromas and nerve sheath myxomas, rare peripheral nerve lesions, which are thought to be derived mainly from the perineurium (Harkin & Reed 1969, Weiser 1975, Lazarus & Trombetta 1978. Many of the original descriptions of anti-EMA antibodies failed to report staining of the perineurium (Heyderman et al.…”

Section: Discussionmentioning

confidence: 99%

Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours

1988

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Specimens of normal peripheral nerve and a series of peripheral nerve lesions have been immunostained with three different anti-epithelial membrane antigen (EMA) monoclonal antibodies. Sites of EMA immunoreactivity have been confirmed within perineurial cells of peripheral nerve, noted within the capsule of Schwannomas and palisaded encapsulated neuromas, and also detected with traumatic neuromas and plexiform neurofibromas. No expression was detected within simple neurofibromas, diffuse neurofibromas or within malignant Schwannomas. These sites of EMA expression concur with the suggested involvement of perineurial cells in the formation of the particular lesions. The relationship between EMA expression by the perineurium and the piaarachnoid membrane is discussed.

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“…Regardless of cell interrelationships the present and previous electron microscopic studies have now demonstrated that benign peripheral nerve sheath tumors may be composed of Schwann cells alone8*24*25.27 of Schwann cells with concommitant fibroblastic proliferation 11917* 21,26,29,32.40 or of perineurial cells alone. 41 It would seem appropriate that the latter tumors should be placed in a category of their own, making three divisions of these tumors by electron microscopy: Schwannomas, neurofibromas and perineuriomas.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural identification of a benign perineurial cell tumor

Lazarus

Trombetta

1978

Cancer

246

117

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A solitary tumor which by light microscopy was classified as a neurofibroma was found by electron microscopic study to be composed of parallel, elongate cells with collagen rich intervening matrix. The cells showed thin, polar cytoplasmic processes which extended long distances, frequent junctional complexes between cell processes, numerous surface vesicles, and either no or fragmented and variable basement membrane. Perineurial cells from small peripheral nerves of skin were demonstrated to have similar morphologic characteristics as the tumor cells. The present study, together with previous ultrastructural findings, indicate that benign peripheral nerve sheath tumors should be placed in at least three categories: Schwannoma, neurofibroma and perineurioma.

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An electron microscope study of ?Pacinian neurofibroma?

Cited by 55 publications

References 33 publications

A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers

A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers

Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours

Ultrastructural identification of a benign perineurial cell tumor

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