An electron microscopic study of the human fetal parathyroid gland

Nakagami, Kazuyoshi; Yamazaki, Yoshio; Tsunoda, Yutaka

doi:10.1007/bf00330589

Cited by 25 publications

(8 citation statements)

References 13 publications

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“…Large vacuolar bodies were also observed both outside and inside the Golgi field. Of these, the vacuolar bodies containing small vesicles belong to the so-called multivesicular bodies described in several animal species (DAVIS and ENDERS, 1961;HARA and NAGATSU-ISHIBASHI, 1964;LANGE and BREHM, 1965; ROGERS, 1965;NAKAGAMI, 1967;CORTELYOU and MCWHINNIE, 1967;HARA and NAGATSU, 1968;NAKAGAMI et al, 1968). In this work, the vacuolar bodies were first rapidly, then gradually decreased in number during experimental states.…”

mentioning

confidence: 71%

Ultrastructural Change in the Parathyroid Gland of the Phosphate Treated Newt, <i>Triturus pyrrhogaster</i> (Boié)

Isono

Sakurai

Fujii

et al. 1971

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. The newt parathyroid gland in natural hibernation and in hyperfunctional conditions induced by the intraperitoneal injection of phosphate was electron-microscopically studied. The average numbers of mitochondria, Golgi apparatus, large homogeneously dense bodies, large heterogeneously dense bodies, vacuolar bodies and lipofuscin-like thyroid glands of the phosphate treated and hibernating (control) newts. The parenchymal cells of the newt parathyroid gland were classified into basal cells and suprabasal cells. Daily administration of phosphate caused no marked changes in the former cells. In the latter under experimental conditions, granular and agranular endoplasmic reticula and small dense granules seemed to be increased in number, while glycogen granules appeared decreased in number when contrasted to those in the control newts. The Golgi apparatus and large homogeneously dense bodies were increased in number reaching a maximum after 7 days of phosphate administration, and lipofuscin-like bodies were gradually increased in number during the experimental stages. On the contrary, vacuolar bodies were first rapidly, then gradually decreased in number. Large heterogeneously dense bodies subdivided into a vesicular type and lysosomal type were slightly decreased during 14 days' administration of phosphate and increased in number after 21 day administration. Under experimental conditions the vesicular type heterogeneously dense bodies were more dominant than the lysosomal type. The numbers of mitochondria were hardly varied as compared with control newts. The ultrastructure of the normal parathyroid gland has been studied extensively. Furthermore, a number of investigations on the fine structure of the parathyroid gland under experimentally hyper-or hypo-functional conditions have been reported in the rat (DAVIS and ENDERS, 1961;RAISZ, 1964, 1966;LEVER, 1965;MAZZOCCHI et al., 1967;HARA and NAGATSU, 1968;ROTH et al., 1968; ROHR and KRASSIG, 1968), frog (MONTSKO et al., 1963a;LANGE and BREHM, 1965), cow (CAPEN et al., 1965), rabbit (MELSON, 1966; TANAKA, 1969a, b; TANAKA et al., 1969a, b), mouse (STOECKEL and PORTS, 1966b;NAKAGAMI, 1967), cat (CAPEN and ROWLAND, 1968) and bat (AZZALI, 1970).However, the morphology of the secretory cycle of the parathyroid gland is still a matter of speculation.By comparison of the parathyroid gland of the naturally hibernating newt (SETOGUTI, ISONO and SAKURAI, 1970a) with phosphate treated ones the present paper aims at the elucidation of the correlations of different types of inclusion bodies in the gland: small dense granules, large homogeneously dense bodies, large heterogeneously dense bodies, vacuolar bodies containing uncoated vesicles and/or coated ones, and Materials and MethodsThe experimental animals used for this work were adult newt, Triturus pyrrhowere daily given 0.4ml of 1% Na2HPO4 solution (phosphate) intraperitoneally for 3, 7, 14 and 21 days.The parathyroid glands from naturally hibernating (control) newts and those treated with phosphate were removed ...

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mentioning

confidence: 71%

Ultrastructural Change in the Parathyroid Gland of the Phosphate Treated Newt, <i>Triturus pyrrhogaster</i> (Boié)

Isono

Sakurai

Fujii

et al. 1971

Arch. Histol. Jap., Arch. Histol. Jpn

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“…and morphological investiga tions have dealt with the problem concerning the effects of a hypergravity environment on the parathyroid gland [10][11][12][13][14][15][16][17], Many reporters have examined the ultrastructure of the parathyroid glands of mammalian fetuses and chick embryos under experimental conditions [18][19][20][21] as well as under normal conditions [22][23][24][25][26][27]. In addition, there have been a few morphological studies concerning the parathy roid glands of pregnant cows [28 , 29], However, there is no study on the effects of a hyper gravity environment on the ultrastructure of the parathy roid glands in fetuses and pregnant animals.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure of the Parathyroid Gland of Fetal and Pregnant Golden Hamsters Subjected to Hypergravity Environment

Shoumura¹,

Emura²,

Utsumi

et al. 1992

Cells Tissues Organs

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The ultrastructure of the parathyroid glands of fetal and pregnant golden hamsters exposed to 5-gravity environment was studied. In the centrifuged fetal animals the Golgi complexes associated with some prosecretory granules were significantly increased compared with those of the control fetal animals, and several secretory granules were located in a peripheral position just beneath the plasma membrane. In the centrifuged pregnant animals the Golgi complexes associated with numerous prosecretory granules were significantly increased, cisternae of the granular endoplasmic reticulum appeared to be increased compared with those of the control pregnant animals, many secretory granules were located in the peripheral cytoplasm and several granules were situated close to the plasma membrane. These findings suggest that in the parathyroid glands of the fetal golden hamsters as well as the pregnant animals the synthesis and release of parathyroid hormone may be stimulated in response to a hypergravity environment.

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“…Some findings have proposed that the primary cilia are only vestigial organelles inherited from an ancestor whose cells had motile cilia and now serve no purpose in multicellular organisms (Sorokin, 1962). It is possible that the presence of ciliated cells in the developing thyroid of grass snake embryos was a result of the pharyngeal origin of this organ because ciliated cells have also been found in other pharyngeal-originated organs such as the thymus (Cordier, 1974), the parathyroid (Munger and Roth, 1963;Nakagami et al, 1968;Isono et al, 1977) and two zones of the ascidian endostyle (Fujita and Nanba, 1971). It is commonly known that the endostyle of most primitive chordates such as the urochordates (tunicates), cephalochordates (craniates) and larval lampreys (ammocoetes) is presumed to be a homolog of the thyroid gland of vertebrate species (Olsson, 1965;Deibel and Powell, 1987;Hiruta et al, 2005;Ogasawara et al, 1999;Bone et al, 2003;Kluge et al, 2005) and that this homology is based on the reorganisation of the larval endostyle into the adult thyroid in lampreys (Cañestro et al, 2008).…”

Section: Discussionmentioning

confidence: 97%

Ultrastructural studies of cilia formation during thyroid gland differentiation in grass snake embryos

Rupik¹

2013

Micron

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An electron microscopic study of the human fetal parathyroid gland

Cited by 25 publications

References 13 publications

Ultrastructural Change in the Parathyroid Gland of the Phosphate Treated Newt, <i>Triturus pyrrhogaster</i> (Boié)

Ultrastructural Change in the Parathyroid Gland of the Phosphate Treated Newt, <i>Triturus pyrrhogaster</i> (Boié)

Ultrastructure of the Parathyroid Gland of Fetal and Pregnant Golden Hamsters Subjected to Hypergravity Environment

Ultrastructural studies of cilia formation during thyroid gland differentiation in grass snake embryos

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