An Electronic Nose Discriminates between the Exhaled Breath of Patients with Pleural Malignant Mesothelioma and Healthy Controls.

Dragonieri, Silvano; Carratù, Pierluigi; Schiavulli, Nunzia Anna; Cavone, Domenica; Tutino, Maria; Gennaro, Gianluigi de; Spanevello, Antonio; Sterk, PJ; Resta, Onofrio; Musti, Marina

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4462

Cited by 3 publications

(1 citation statement)

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“…To date, only one abstract has been published on this topic and this relates to MM. Dragonieri et al were successful in distinguishing between histologically diagnosed pleural malignant mesothelioma and control subjects, with 90% cross validation [53]. In relation to lung cancer, there is increasing evidence that the electronic nose can diagnose lung cancer with a high sensitivity and specificity (see below); however, no work has been published specifically on asbestos-related lung cancer to date.…”

Section: Asbestos-related Disease 'Smellprints'mentioning

confidence: 99%

Breath analysis in asbestos-related disorders: a review of the literature and potential future applications

Chapman¹,

Thomas²,

Yates³

2010

J. Breath Res.

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Asbestos usage was very common worldwide in the last century and continues in several countries today. Several diseases occur due to asbestos exposure, including malignant tumours such as malignant mesothelioma of the pleura and lung cancer, which have a very poor prognosis. Asbestos inhalation may also result in more benign conditions such as asbestosis (or pulmonary fibrosis due to asbestos), pleural plaques and pleural thickening. It is predicted that asbestos-associated mortality and morbidity will continue to increase, but methods for diagnosing asbestos-related disease are currently invasive and unsuitable for an increasingly elderly population. New non-invasive methods such as analysis of exhaled breath biomarkers e.g. exhaled nitric oxide (F(E)NO), exhaled breath condensate or of exhaled volatile organic compounds could potentially be extremely useful in these conditions. This article reviews the current literature on this topic and suggests areas for their application in the future.

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Section: Asbestos-related Disease 'Smellprints'mentioning

confidence: 99%

Breath analysis in asbestos-related disorders: a review of the literature and potential future applications

Chapman¹,

Thomas²,

Yates³

2010

J. Breath Res.

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Atteinte maligne de la plèvre

Dhalluin

2009

Revue des Maladies Respiratoires Actualités

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A breath test for malignant mesothelioma using an electronic nose

et al. 2011

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Malignant mesothelioma (MM) is a rare tumour which is difficult to diagnose in its early stages. Earlier detection of MM could potentially improve survival. Exhaled breath sampling of volatile organic compounds (VOCs) using a carbon polymer array (CPA) electronic nose recognises specific breath profiles characteristic of different diseases, and can distinguish between patients with lung cancer and controls. With MM, the potential confounding effect of other asbestos-related diseases (ARDs) needs to be considered. We hypothesised that as CPA electronic nose would distinguish patients with MM, patients with benign ARDs, and controls with high sensitivity and specificity.20 MM, 18 ARD and 42 control subjects participated in a cross-sectional, case-control study. Breath samples were analysed using the Cyranose 320 (Smiths Detection, Pasadena, CA, USA), using canonical discriminant analysis and principal component reduction.10 MM subjects created the training set. Smell prints from 10 new MM patients were distinguished from control subjects with an accuracy of 95%. Patients with MM, ARDs and control subjects were correctly identified in 88% of cases.Exhaled breath VOC profiling can accurately distinguish between patients with MM, ARDs and controls using a CPA electronic nose. This could eventually translate into a screening tool for high-risk populations.

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An Electronic Nose Discriminates between the Exhaled Breath of Patients with Pleural Malignant Mesothelioma and Healthy Controls.

Cited by 3 publications

References 0 publications

Breath analysis in asbestos-related disorders: a review of the literature and potential future applications

Breath analysis in asbestos-related disorders: a review of the literature and potential future applications

Atteinte maligne de la plèvre

A breath test for malignant mesothelioma using an electronic nose

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