An elevated preoperative plasma fibrinogen level is associated with poor overall survival in Chinese gastric cancer patients

Wang, Yu; Wang, Yongfeng; BoMing, Shen

doi:10.1016/j.canep.2016.03.004

Cited by 34 publications

(34 citation statements)

References 35 publications

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“…These findings are in accordance with previous reports regarding other malignancies, such as lung, [35] esophageal, [36] gastric, [37] colorectal, [34] and ovarian [7] cancer. Most importantly, high plasma fibrinogen levels have been correlated with poor response to therapy, including response to trastuzumab treatment in HER2-positive breast cancer.…”

Section: Discussionsupporting

confidence: 93%

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Zhang

Long²

2017

Medicine

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Hyperfibrinogenemia has been reported to be a predictor of poor prognosis in cancer patients, and in hepatocellular carcinoma (HCC) patients, survival remains uncertain and unpredictable. The aim of the present study was to evaluate the association between the level of plasma fibrinogen and overall survival in HCC patients.Overall, 308 patients with histologically proven HCC were included in our study. Univariate and multivariate analyses were performed to identify predictive risk factors for the rates of overall survival and tumor recurrence.Patients in the high-fibrinogen-level group were more likely to have advanced stage HCC, portal vein invasion, and tumors that were greater in number and larger in diameter than were patients in the low-fibrinogen-level group (all P < .05). The long-term overall survival rate of patients in the high-fibrinogen group was much lower than that of patients in the normal-fibrinogen group (P = .008), and similar outcomes were observed in the subgroup of patients who underwent radical therapies for HCC (P = .003). The results of the univariate and multivariate analyses indicated that high plasma fibrinogen remained independently associated with poorer overall survival. In addition, high plasma fibrinogen levels were associated with nonresponse to transarterial chemoembolization (TACE) (P < .001).Elevated plasma fibrinogen was independently associated with advanced HCC stage, poor prognosis, and nonresponse to TACE and may, therefore, serve as a valuable clinical biomarker for predicting prognosis in HCC patients.

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Section: Discussionsupporting

confidence: 93%

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Zhang

Long²

2017

Medicine

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“…In a recent considerable cohort of 1090 gastric cancer patients treated by gastrectomy, high fibrinogen level (exceeding the ROCidentified cut-off at 3.9 g/L) was significantly associated with tumour size, T, N and TNM stage [113]. Fibrinogen shows statistically significant associations with the invasion depth of gastric cancer confirmed by several other studies focusing on T [122][123][124].…”

Section: Fibrinogen In Gastric Cancer Evaluationsupporting

confidence: 67%

“…The independent prognostic role was confirmed in another large surgically treated cohort of 1196 gastric cancer patients [112]. Applying ROC-identified cut-off (3.9 g/L), high fibrinogen level was significantly associated with overall survival in multivariate analysis [113]. In patients who underwent curative gastrectomy, hyperfibrinogenaemia (reaching or exceeding 350 mg/dL) was associated not only with overall but also cancer-free survival.…”

Section: Fibrinogen In Gastric Cancer Evaluationmentioning

confidence: 65%

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Štrumfa¹,

Bogdanova²,

Kalva³

et al. 2017

Gastric Cancer

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Gastric cancer induces systemic inflammatory reaction (SIR) manifesting with changes in counts of white blood cell fractions and concentrations of acute phase proteins, clotting factors and albumins. Thus, protein-based scores or blood cell ratios (neutrophil to lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR)) are used to evaluate SIR. SIR tests are biologically justified by multiple clinically important and fascinating events including bone marrow activation, development of immune-suppressing immature myeloid cells, generation of pre-metastatic niches and neutrophil extracellular trap formation from externalised DNA network in bidirectional association with platelet activation. Despite biological complexity, clinical SIR assessment is widely available, patient-friendly and economically feasible. Here we present concise review on NLR, PLR, Glasgow prognostic score and fibrinogen -parameters that have prognostic role regarding overall, cancer-free and cancer-specific survival in early and advanced cases. Tumour burden can be predicted helping in preoperative detection of serosal or lymph node involvement. Practical consequences abound, including selection of surgical approach in respect to tumour burden, adjustments in treatment intensity by prognosis or evaluation of chemotherapy response. The chapter also scrutinises main controversies including different cut-off levels. Future developments should include elaboration of complex scores as described here. SIR parameters should be wisely incorporated in patients' treatment.

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“…Similarly, in a retrospective study conducted on 1196 patients with GC, serum FBG levels correlated with advanced tumor stages and as an independent factor for poor survival, a useful biomarker for patients with clinically advanced GC . In a retrospective cohort study of 1090 Chinese patients treated for GC, plasma FBG level was shown to be significantly associated with age, tumor size, invasion depth, lymph node metastasis, TNM (tumor, node, and metastasis) stage, and carcinoembryonic antigen (CEA) level, emerging as an independent marker of poor prognosis . Moreover, two other studies confirmed FBG concentration together with neutrophil/lymphocyte ratio as prognostic markers of GC .…”

Section: Coagulation‐related Proteins and Cancermentioning

confidence: 80%

“…112 In a retrospective cohort study of 1090 Chinese patients treated for GC, plasma FBG level was shown to be significantly associated with age, tumor size, invasion depth, lymph node metastasis, TNM (tumor, node, and metastasis) stage, and carcinoembryonic antigen (CEA) level, emerging as an independent marker of poor prognosis. 113 Moreover, two other studies confirmed FBG concentration together with neutrophil/lymphocyte ratio as prognostic markers of GC. 114,115 Hyperfibrinogenemia was previously found to be associated with lymphatic metastasis and worse clinical outcome in GC.…”

mentioning

confidence: 90%

Coagulation and fibrinolysis in gastric cancer

Repetto

2017

Annals of the New York Academy of Sciences

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Coagulation is a highly conserved process occurring after an injury to a blood vessel and resulting in hemostasis. In the thrombus microenvironment, finely orchestrated events restore vessel integrity through platelet activation, adhesion, and aggregation (primary hemostasis), followed by the coagulation cascades, thrombin generation, and fibrin clot deposition (secondary hemostasis). Several studies on cancer have provided insight into dramatic changes to coagulation-related events (i.e., fibrin clot deposition, fibrinolysis) during tumor pathogenesis, progression, and metastasis, in addition to a tumor-driven systemic activation of hemostasis and thrombosis (Trousseau's syndrome). Diverse molecular and cellular effectors participate in the cross talk between hemostasis and tumors. Here, we focus on some aspects of the interconnection between cancer biology and hemostatic components, with particular attention to some key coagulation-related proteins (e.g., tissue factor, thrombin, fibrinogen, and D-dimers) in the particular case of gastric cancer (GC). Recent advances in deciphering the complex molecular link between GC and the coagulation system are described, showing their important roles in better management of patients affected by GC.

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An elevated preoperative plasma fibrinogen level is associated with poor overall survival in Chinese gastric cancer patients

Cited by 34 publications

References 35 publications

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters

Coagulation and fibrinolysis in gastric cancer

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