PurposeToday, the use of smart technologies in healthcare systems is experiencing exponential growth, and the future of healthcare is seemingly closely intertwined with such technologies. Thus, any exploration of the factors that influence human health and healthcare systems inevitably touches upon the subject of new technologies. This study aims to design a conceptual model to investigate the elements that affect individuals' openness to accepting and using mobile healthcare applications (mHealth apps) and their reciprocal effects.Design/methodology/approachAfter a brief review of the literature, the authors identify the influential factors in the acceptance of smart technologies in healthcare systems and present a conceptual model in this regard. Next, the authors analyze the factors and variables and the extent of their impact by a structural equation modeling (SEM) approach. The statistical population of this study consists of 421 individuals including the developers, consultants and users (i.e. patients) of mHealth apps. Data analysis was done on the statistical software SPSS v.26, while SEM was carried out using the partial least squares (PLS) method on the modeling software SmartPLS.FindingsThe results indicate that user, consultant and developer preferences have a positive and significant impact on time, quality of life, managing chronic conditions and cooperation, and these constructs (system performance) finally have a positive and significant impact on the acceptance of mobile healthcare technologies.Originality/valueThis paper shows that mHealth apps can have a remarkable role in the prevention and treatment of medical conditions, and it is strongly recommended that this technology be utilized in the studied region.