Th e present study reviews the most common N effi ciency indexes with a view to maximizing yield and minimizing N loss, for melon grown in a zone where the water supply has a high nitrate content due to environmental degradation. Th e N use effi ciency (NUE) values of the study were those relating the fruit yield (FY) and the dry weight (DW) with N applied (N ap ), N available (N av ), and N uptake (N up ), which were denominated NUE 1 , NUE 2 , NUtE, NUE 3 , NUE 4 , and NUE 5 , respectively. A 3-yr fi eld experiment (2005, 2006, and 2007) was performed from May to September in central Spain. Melon crops were irrigated at 100% of the ET c (crop evapotranspiration) and 11 N rates, ranging from 11 to 393 kg ha -1 (considering N fertilizer [N f ], applied over 10 wk, and N in the irrigation water [N w ], where the NO 3 concentration was 5.58, 80.64, and 10.89 mg L -1 in 2005, 2006, and 2007, respectively), were applied to a soil classifi ed as Alfi sol Xeralf Petrocalcic Palexeralfs. Th e results show a clear relationship between crop N up and both FY and DW. Of the potential yield, 95% could be obtained with a N application of 93 kg ha -1 . Th e maximum FY was observed with a N up of 155 kg ha -1 . Th e NUE, when related to N ap and N av , showed an exponential trend and when related to N up a linear trend, delimiting a range within which the optimum value of N occurs.