An environmentally benign approach for the synthesis of bifunctional sulfonamide-amide compounds via isocyanide-based multicomponent reactions

An Efficient One‐Pot Synthesis of Chiral N‐Protected 3‐Substituted (Diketo)piperazines via Ugi‐4CR/De‐Boc/Cyclization Process

“…In order to explore green conditions and reduce reaction times, we decided to explore Ugi‐4CRs carried out in safer/more benign solvents ,. Hence, one of the promising methods is performing isocyanide‐based MCRs in water . Indeed, Pirrung et al.…”

Quinazolinone novel derivatives synthesis and their Biological Evaluation as Antimicrobial and Antitubercular agents

“…Hence, from all these discussions we concluded that there is a requirement to develop anti-TB drugs with improved properties such as increased activity, reduced toxicity, shows the low duration of action, ability to penetrate host cells etc. Due to the above reasons and as a part of our research on the synthetic methods we synthesize compounds (Shaabani et al, 2009(Shaabani et al, , 2011, a series of quinazolinone compounds were synthesized and evaluated for antimicrobial and the compounds which showed potent activity were further performed antitubercular activity.…”

Betainium-based ionic liquids catalyzed multicomponent Hantzsch reactions for the efficient synthesis of acridinediones

“…Multicomponent reactions (MCRs) have received a great deal of attention in organic synthesis and combinatorial chemistry due to their wide supplement of molecular diversity and high atom economic efficiency. 1,2 Although MCRs can provide high throughput generation of organic compounds, oen in a onepot strategy, they still suffer from the utilization of excessive reagents and toxic solvents, harsh reaction conditions and long reaction time. Therefore, appropriately selected catalyst or reaction medium for special MCRs plays a critical role towards the development of green processes.…”