An Enzyme‐Responsive Polymeric Superamphiphile

Wang, Chao; Chen, Qishui; Wang, Zhiqiang; Zhang, Xi

doi:10.1002/anie.201004253

Cited by 201 publications

(104 citation statements)

References 62 publications

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“…DOX-loaded polysaccharide-lecithin reverse micelles, with a triglyceride outer shell that was sensitive to hydrolysis by lysosomal acid lipase, were reported to overcome multi-drug resistance (Su et al, 2013). Enzyme-responsive polyion complex micelles (PICs) that disintegrate in response to phosphatase and acetylcholinesterase respectively have been developed by Zhang and co-workers (Wang et al, 2010a; Xing et al, 2012). …”

Section: Polymeric Micelles: Background and Relevance As Therapeutic mentioning

confidence: 99%

Multifunctional polymeric micelles for delivery of drugs and siRNA

2014

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Polymeric micelles, self-assembling nano-constructs of amphiphilic copolymers with a core-shell structure have been used as versatile carriers for delivery of drugs as well as nucleic acids. They have gained immense popularity owing to a host of favorable properties including their capacity to effectively solubilize a variety of poorly soluble pharmaceutical agents, biocompatibility, longevity, high stability in vitro and in vivo and the ability to accumulate in pathological areas with compromised vasculature. Moreover, additional functions can be imparted to these micelles by engineering their surface with various ligands and cell-penetrating moieties to allow for specific targeting and intracellular accumulation, respectively, to load them with contrast agents to confer imaging capabilities, and incorporating stimuli-sensitive groups that allow drug release in response to small changes in the environment. Recently, there has been an increasing trend toward designing polymeric micelles which integrate a number of the above functions into a single carrier to give rise to “smart,” multifunctional polymeric micelles. Such multifunctional micelles can be envisaged as key to improving the efficacy of current treatments which have seen a steady increase not only in hydrophobic small molecules, but also in biologics including therapeutic genes, antibodies and small interfering RNA (siRNA). The purpose of this review is to highlight recent advances in the development of multifunctional polymeric micelles specifically for delivery of drugs and siRNA. In spite of the tremendous potential of siRNA, its translation into clinics has been a significant challenge because of physiological barriers to its effective delivery and the lack of safe, effective and clinically suitable vehicles. To that end, we also discuss the potential and suitability of multifunctional polymeric micelles, including lipid-based micelles, as promising vehicles for both siRNA and drugs.

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Section: Polymeric Micelles: Background and Relevance As Therapeutic mentioning

confidence: 99%

Multifunctional polymeric micelles for delivery of drugs and siRNA

2014

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“…Upon treatment with alkaline phosphatase (e.g. CIAP), the spherical aggregates will disassemble and release the loaded guest molecules [19]. In addition, chitosan and ATP are used as building blocks to fabricate polymeric supra-amphiphiles based on electrostatic interactions, which can self-assemble to form spherical aggregates.…”

Section: Polymeric Supra-amphiphilesmentioning

confidence: 99%

Macromolecular self-assembly and nanotechnology in China

Chen

Wang

et al. 2013

Phil. Trans. R. Soc. A.

Self Cite

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Macromolecular self-assembly refers to the assembly of synthetic polymers, biomacromolecules and supra-molecular polymers. Through macromolecular self-assembly, the fabrication of ordered structures at different scales, the control of the dynamic assembly process and the integrations of advanced functions can be realized. Macromolecular self-assembly and nanotechnology research in China has developed rapidly, from the early periods of follow-up at low to high level and progress into a stage of innovation and creation. This review selects some representative progresses achieved recently, aiming to reflect the current status of macromolecular self-assembly and nanotechnology research in China.

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“…14 When resistant to degradation, 15 these conjugates can be used to build dynamic enzyme-responsive materials. 16–19 The use of (poly)peptides also can mediate assembly of predefined morphologies, such as micelles, vesicles, liposomes, and nanoparticles, which are widely used as delivery vehicles. 20–22 (Poly)peptides have also been extensively used as targeting ligands, the most widely employed example being the integrin-binding sequence RGD, 23 and as a whole, the development of peptide-polymer conjugates has opened new avenues for different biomedical applications (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Responsive hybrid (poly)peptide–polymer conjugates

et al. 2017

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(Poly)peptide-polymer conjugates continue to garner significant interest in the production of functional materials given their composition of natural and synthetic building blocks that confer select and synergistic properties. Owing to opportunities to design predefined architectures and structures with different morphologies, these hybrid conjugates enable new approaches for producing micro- or nanomaterials. Their modular design enables the incorporation of multiple responsive properties into a single conjugate. This review presents recent advances in (poly)peptide-polymer conjugates for drug-delivery applications, with a specific focus on the utility of the (poly)peptide component in the assembly of particles and nanogels, as well as the role of the peptide in triggered drug release.

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An Enzyme‐Responsive Polymeric Superamphiphile

Cited by 201 publications

References 62 publications

Multifunctional polymeric micelles for delivery of drugs and siRNA

Multifunctional polymeric micelles for delivery of drugs and siRNA

Macromolecular self-assembly and nanotechnology in China

Responsive hybrid (poly)peptide–polymer conjugates

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