An epidemiological study on skin tumors of the elderly in a community in Shanghai, China

Huang, Jianhua; Zhang, Linglin; Shi, Lei; Wu, Meiyan; Lv, Ting; Zhang, Yunfeng; Lai, Yongxian; Tu, Qingfeng; Wang, Xiuli; Wang, Hongwei

doi:10.1038/s41598-023-29012-1

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Specifically, the incidence of cSCC has been reported to be 5 to 10 times higher in people over 75 years of age than in people under 55, and as much as 50 to 300 times higher in people under 45 [ 35 – 37 ]. Moreover, a survey of residents over 60 in a community in Shanghai, China, found that skin cancer tended to increase with age, especially in groups over 75 years old [ 38 ]. Patients with cSCC may exhibit more chronic sun injury, leading to experiencing multiple cSCCs across their lives, which could be linked to specific patterns of total and cumulative UV exposure [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Huang,

Jiang,

Wong

et al. 2024

J Glob Health

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Background China has the highest number of new cancer cases and deaths globally. Due to particularly low scores in health care quality for cutaneous squamous cell carcinoma (cSCC), the country’s cSCC burden requires greater awareness. Consequently, we aimed to evaluate and predict the trend of the cSCC burden globally and in China from 1990 to 2030. Methods We retrieved data from the Global Burden of Disease 2019 study, which provided estimates of the incidence, mortality, prevalence, and disability-adjusted life years (DALYs) of cSCC from 1990 to 2019. We set up joint-point analyses and Bayesian age-period-cohort (BAPC) models to predict the disease burden of cSCC up to 2030. Results In 2019, China reported age-standardised rates of cSCC prevalence, incidence, mortality, and DALYs of 2.54, 2.12, 0.88, and 16.76 per 100 000 population, respectively. The country’s prevalence and incidence rates from 1990 to 2019 were lower than the global levels, but its mortality and DALY rates were higher. The age-standardised rates were higher for males, and the disease burden increased with each age group globally and in China. Moreover, the average annual percentage change showed all indicators were growing faster than the global levels. According to the BAPC model, there will be an upward trend in the prevalence and incidence globally and in China between 2020 and 2030, with a decrease in mortality and DALYs. Conclusions We observed an upward trend in the cSCC burden over the past 30 years in China. Prevalence and incidence are expected to continue at a higher rate than the global average in the next decade, while mortality and DALYs are predicted to decrease. As the Chinese population ages, efforts toward managing and preventing cSCC should be targeted towards the elderly population.

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Section: Discussionmentioning

confidence: 99%

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Huang,

Jiang,

Wong

et al. 2024

J Glob Health

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“…The progression of various types of melanoma is linked with UV radiation exposure patterns . Long-term susceptibility such as occupational outdoor exposure is frequently linked to SCC and BCC SC. , The superficial BCC usually appears on the trunk . As compared to SCC, melanoma is commonly associated with irregular exposure .…”

Section: Skin Cancer Occurs Due To the Involvement Of Various Factorsmentioning

confidence: 99%

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Dachani,

Kaleem,

Mujtaba

et al. 2024

ACS Omega

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Skin cancer (SC) poses a global threat to the healthcare system and is expected to increase significantly over the next two decades if not diagnosed at an early stage. Early diagnosis is crucial for successful treatment, as the disease becomes more challenging to cure as it progresses. However, identifying new drugs, achieving clinical success, and overcoming drug resistance remain significant challenges. To overcome these obstacles and provide effective treatment, it is crucial to understand the causes of skin cancer, how cells grow and divide, factors that affect cell growth, and how drug resistance occurs. In this review, we have explained various therapeutic approaches for SC treatment via ligands, targeted photosensitizers, natural and synthetic drugs for the treatment of SC, an epigenetic approach for management of melanoma, photodynamic therapy, and targeted therapy for BRAFmutated melanoma. This article also provides a detailed summary of the various natural drugs that are effective in managing melanoma and reducing the occurrence of skin cancer at early stages and focuses on the current status and future prospects of various therapies available for the management of skin cancer.

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Skin health of community-living older people: a scoping review

Kottner,

Fastner,

Lintzeri

et al. 2024

Arch Dermatol Res

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The population of older people is steadily increasing and the majority live at home. Although the home and community are the largest care settings worldwide, most of the evidence on dermatological care relates to secondary and tertiary care. The overall aims were to map the available evidence regarding the epidemiology and burden of the most frequent skin conditions and regarding effects of screening, risk assessment, diagnosis, prevention and treatment of the most frequent skin conditions in older people living in the community. A scoping review was conducted. MEDLINE, Embase and Epistemonikos were systematically searched for clinical practice guidelines, reviews and primary studies, as well as Grey Matters and EASY for grey literature published between January 2010 and March 2023. Records were screened and data of included studies extracted by two reviewers, independently. Results were summarised descriptively. In total, 97 publications were included. The vast majority described prevalence or incidence estimates. Ranges of age groups varied widely and unclear reporting was frequent. Sun-exposure and age-related skin conditions such as actinic keratoses, xerosis cutis, neoplasms and inflammatory diseases were the most frequent dermatoses identified, although melanoma and/or non-melanoma skin cancer were the skin conditions investigated most frequently. Evidence regarding the burden of skin conditions included self-reported skin symptoms and concerns, mortality, burden on the health system, and impact on quality of life. A minority of articles reported effects of screening, risk assessment, diagnosis, prevention and treatment, mainly regarding skin cancer. A high number of skin conditions and diseases affect older people living at home and in the community but evidence about the burden and effective prevention and treatment strategies is weak. Best practices of how to improve dermatological care in older people remain to be determined and there is a particular need for interventional studies to support and to improve skin health at home.

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An epidemiological study on skin tumors of the elderly in a community in Shanghai, China

Cited by 6 publications

References 46 publications

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

Global burden and prediction study of cutaneous squamous cell carcinoma from 1990 to 2030: A systematic analysis and comparison with China

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Skin health of community-living older people: a scoping review

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