An epidemiological study to establish the prevalence of urinary symptoms and felt need in the community: the Leicestershire MRC incontinence study

Perry, Sarah; Shaw, Christine; Assassa, Philip; Dallosso, Helen; Williams, Kate; Brittain, Katie; Mensah, Fiona; Smith, Nadine; Clarke, M.; Jagger, Carol; Mayne, Christopher; Castleden, C. M.; Jones, Jonathan; McGrother, Catherine W.

doi:10.1093/pubmed/22.3.427

Cited by 179 publications

(151 citation statements)

References 40 publications

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“…In women, urinary incontinence is estimated to affect nearly 50% of middle aged and older women, leading to significant distress, limitations in daily functioning, and poorer quality of life (8,9). Diabetes has been identified as an important independent risk factor for incontinence in several large observational studies, including the Nurses' Health Study, and is associated with 30 -100% increased risk (9 -12).…”

Section: Bladder Dysfunction In Womenmentioning

confidence: 99%

Urologic Complications of Diabetes

et al. 2005

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Section: Bladder Dysfunction In Womenmentioning

confidence: 99%

Urologic Complications of Diabetes

et al. 2005

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“…Using this definition it is clear that nocturia is frequent among the adult population. In a UK study of 2074 women aged ≥ 19 years Swithinbank et al [9] found a prevalence rate of 16%, while another UK study [10] found that 20% of men and 21% of women aged > 40 years had nocturia. A study in the USA among a population aged ≥ 60 years showed prevalence rates for men of 25% and for women of 24% [11].…”

Section: Introductionmentioning

confidence: 99%

Nocturia in the Dutch adult population

2002

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Objective To estimate the prevalence of nocturia in the Dutch adult population, its association with sociodemographic and health characteristics, and to assess problems experienced by persons with nocturia. Subjects and methods In spring 2001 a telephone survey was conducted among a representative sample of 4721 Dutch respondents (response 53%). Using questions from the Bristol Lower Urinary Tract Symptoms questionnaire respondents were asked about having nocturia and the problems they experienced. In addition, questions were asked about sociodemographic and health characteristics. Results The prevalence of nocturia (a mean of twice or more/night) among Dutch men and women over 18 years old was 13%, standardized for age and sex.Women had nocturia more often than men (16% vs 9%) and the prevalence was positively associated with age, poor health status and use of medication. Conclusion The prevalence of nocturia in Dutch men and women differs more than reported in earlier studies. The prevalence in the Netherlands seems slightly higher than in other Western countries, but Dutch persons with nocturia report fewer problems. Nocturia does not occur in isolation and is associated with sleep disturbances. It is worthwhile for general practitioners to routinely check whether patients who contact them for lower urinary tract symptoms or sleeping disorders have nocturia.

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“…Pelvic floor dysfunction (PFD), mainly including stress urinary incontinence (SUI), pelvic organ prolapse (POP), and fecal incontinence (FI), is common in women and more prevalent in the aging population [1][2][3]. PFD is a complex disease that involves many factors, and the majority of research suggests that the total collagen content is decreased in pelvic connective tissue and that the pelvic support tissues (the ligament, muscle and fascia) are relaxed because of reduced collagen fibers, which eventually leads to PFD [4,5].…”

Section: Introductionmentioning

confidence: 99%

Mechanical stretching promotes the differentiation of BMSC into pelvic floor ligament fibroblasts

Zhao¹,

Wang²,

Ren³

et al. 2018

Oncotarget

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Pelvic floor dysfunction (PFD) is a prevalent and debilitating condition in agingwomen that is associated with weakened pelvic connective tissue. Fibroblasts are the main component of pelvic connective tissue and play a vital role in the maintenance of the pelvic organ. Mechanical stretching is a known modulator leading to the proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs). In this paper, we measured the lysyl oxidase (LOX), elastin and KDM4B expression in cultured BMSCs under different cyclic mechanical stretch (CMS) conditions via Western blot assays. Our findings indicated that the expression of these proteins was significantly higher in the CMS group than in the normal control group, and 10% CMS at a 0.5 Hz frequency had the best stimulatory effect. We further evaluated the influence of KDM4B on LOX and elastin expression via knockdown and overexpression of KDM4B in BMSCs. Chromatin immunoprecipitation (ChIP)-PCR analysis was performed to determine how H3K9me3 and KDM4B affect the regulatory regions of LOX and elastin in BMSCs subjected to 10% CMS combined with KDM4B knockdown. Finally, we verified the expression of KDM4B under CMS in vivo by subcutaneously transplanting KDM4B-overexpressing BMSCs into mice via immunofluorescence assays. The results showed that activating KDM4B by mechanical stretching increased the protein and gene expression levels of LOX and elastin and induced more LOX-positive cells in the BMSCs. These data suggest that CMS contributes to the differentiation of mesenchymal stem cells (MSCs) into fibroblasts, which indicates its potential use as a cell-based therapy for PFD.

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An epidemiological study to establish the prevalence of urinary symptoms and felt need in the community: the Leicestershire MRC incontinence study

Cited by 179 publications

References 40 publications

Urologic Complications of Diabetes

Urologic Complications of Diabetes

Nocturia in the Dutch adult population

Mechanical stretching promotes the differentiation of BMSC into pelvic floor ligament fibroblasts

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