An Evaluation of Temporal Distributions of High, Low, and Zero Cohort Morbidity of Cumulative First Treatment Bovine Respiratory Disease and Their Associations with Demographic, Health, and Performance Outcomes in US Feedlot Cattle

Abstract

Timing and magnitude of bovine respiratory disease (BRD) can impact intervention and overall economics of cattle on feed. Furthermore, there is a need to better describe when cattle are being treated for BRD. The first objective was to perform a cluster analysis on the temporal distributions of cumulative first treatment BRD from HIGH (≥15% of cattle received treated for BRD) and LOW cohorts (>0 and <15% of cattle received treated for BRD) to assess cohort-level timing (days on feed) of BRD first treatments. The second objective was to determine associations among cluster groups (temporal patterns) and demographic risk factors, health outcomes, and performance. Cluster analysis determined that optimal number of clustering groups for the HIGH morbidity cohort was six clusters and LOW morbidity cohort was seven clusters. Cohorts with zero BRD treatment records were added for statistical comparisons. Total death loss, BRD morbidity, average daily gain (ADG), railing rate, days to 50% BRD, cattle received, shrink, arrival weight, and sex were associated with temporal groups (p < 0.05). These data could be used as a tool for earlier identification and potential interventions for cohorts based on the BRD temporal pattern.

Immunomodulation by cannabidiol in bovine primary ruminal epithelial cells

“…In ruminants, especially feedlot cattle and high producing dairy cows [ 15 , 16 ], the use of high concentrate diets to meet energy requirements can result in ruminal acidosis and subsequent complications such as inflammation of the ruminal epithelium [ 17 ]. Additionally, several events in the production system, such as weaning and shipping, predispose ruminants to stress and disease and result in economic losses associated with reduced weight gain [ 18 ]. A compound such as CBD could be have value as a treatment for disorders such as ruminal acidosis, thereby reducing the cell damage to the ruminal epithelium caused by a prolonged local, inflammatory response [ 17 ].…”