An evaluation of the effect of ozone therapy on tissues surrounding dental implants

Shekhar, Abhinav; Srivastava, Shitij; Bhati, Love Kumar; Chaturvedi, Anshuman; Singh, Shivesh; Agarwal, Bhaskar; Arora, Khitiz

doi:10.1016/j.intimp.2021.107588

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…Another study on implant surgery reported that O 3 accelerated implant wound healing when ozonated water was irrigated at a concentration of 25 µg/mL, along with ozone gas during osteotomy, compared to a saline irrigation group [ 27 ]. Isler et al (2018) instead compared the impact of additional topical gaseous ozone therapy on the decontamination of implant surfaces in the surgical regenerative therapyof peri-implantitis [ 28 ].…”

Section: Oxygen Therapymentioning

confidence: 99%

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

et al. 2022

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Oral mucosa serves as the primary barrier against pathogen invasions, mechanical stresses, and physical trauma. Although it is generally composed of keratinocytes and held in place by desmosomes, it shows variation in tissue elasticity and surface keratinization at different sites of the oral cavity. Wound healing undergoes four stages of tissue change sequences, namely haemostasis, inflammation, proliferation, and remodelling. The wound healing of oral hard tissue and soft tissue is largely dependent on the inflammatory response and vascular response, which are the targets of many research. Because of a less-robust inflammatory response, favourable saliva properties, a unique oral environment, and the presence of mesenchymal stem cells, oral wounds are reported to demonstrate rapid healing, less scar formation, and fewer inflammatory reactions. However, delayed oral wound healing is a major concern in certain populations with autoimmune disorders or underlying medical issues, or those subjected to surgically inflicted injuries. Various means of approach have been adopted to improve wound tissue proliferation without causing excessive scarring. This narrative review reappraises the current literature on the use of light, sound, mechanical, biological, and chemical means to enhance oxygen delivery to wounds. The current literature includes the use of hyperbaric oxygen and topical oxygen therapy, ultrasounds, lasers, platelet-rich plasma (PRP)/platelet-rich fibrin (PRF), and various chemical agents such as hyaluronic acid, astaxanthin, and Centella asiatica to promote angiogenesis in oral wound healing during the proliferation process. The arrival of a proprietary oral gel that is reported to improve oxygenation is highlighted.

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Section: Oxygen Therapymentioning

confidence: 99%

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

et al. 2022

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“…Ozone is used in low concentrations and, therefore, can be considered a safe treatment when used correctly by a qualified professional. Shekhar et al (2021) evaluated the effect of ozone therapy on inflammation, pain, and wound healing after implant surgery. They observed that ozone therapy accelerated healing, minimized tissue inflammation, and lessened pain.…”

Section: F Accini 2021mentioning

confidence: 99%

Use and Applicability of Ozone Therapy in Clinical Practice in Dentistry: An Integrative Review

Meira

Santos

Lima

et al. 2022

Int. J. Odontostomat.

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Ozone is a colorless gas with a characteristic odor present in nature in the form of trivalent oxygen. In 2015, the Federal Council of Dentistry (CFO/Brazil) approved the use of ozone therapy and in 2018 the Ministry of Health (MS/Brazil) approved the application of Ozone Therapy as a Complementary Integrative Practice in the Unified Health System. Therefore, the objective of this study was to verify the applicability of ozone therapy in dental practice. This is an integrative literature review whose search was performed in the Medline/Pubmed, LILACS, SciElo, and Google Scholar databases. Studies published in the last 5 years in English, Portuguese or Spanish were eligible. After the search, 312 titles were found and after exclusion of duplicates and analysis of abstracts and full text, 13 articles were included in this review. The literature reports the application of ozone therapy in several areas in the treatment of acute and chronic diseases. As a mechanism of action, ozone has a direct antimicrobial effect, immunoregulation, antioxidant defenses, analgesic, and vasodilator effects. In dentistry, its applicability is mainly in preventive dentistry and as a complement in surgical procedures, endodontic, and periodontal treatments.

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“…Focusing on the applicability of ozone in dentistry, several clinical conditions have been treated by recourse to ozone therapy, e.g., the management of wound-healing, dental caries, oral lichen planus, gingivitis and periodontitis, halitosis, osteonecrosis of the jaw, post-surgical pain, plaque and biofilms, root canal treatment, dentin hypersensitivity, temporomandibular joint disorders, and teeth whitening [7][8][9][10]. Moreover, ozone is also used as a functionalizing agent on implant surfaces (for both dental and orthopedic use) with the goal of improving their osseointegration [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Ozonized Water Administration in Peri-Implant Mucositis Sites: A Randomized Clinical Trial

et al. 2021

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Peri-implant mucositis represents an inflammatory lesion of the mucosa surrounding an endosseous implant, without the loss of the supporting peri-implant bone. Considering its reversible nature, every effort should be made to contrast it, thus avoiding the eventual progression towards peri-implantitis. The aim of the present randomized clinical trial is to evaluate the efficacy of the ozonized water against peri-implant mucositis. A total of 26 patients diagnosed for this latter clinical condition were randomly divided according to the professional oral hygiene protocol performed on the pathological sites at baseline, at T1 (1 month), and T2 (2 months). Group 1 underwent an ozonized water administration (experimental treatment), whereas Group 2 underwent a pure water one (control treatment). Both administrations were performed with the same professional irrigator (Aquolab® professional water jet, Aquolab s.r.l. EB2C S.r.l., Milano, Italy) with no differences in color or taste between the two substances delivered. At each appointment, the following indexes were assessed: the Probing Pocket Depth (PPD), Plaque Index (PI), Bleeding on Probing (BoP), and Bleeding Score (BS). As regards intragroup differences, in Group 1 ozonized water significantly and progressively reduced all the clinical indexes tested, except for PI in the period T1–T2, whereas no significant differences occurred within the control group. Despite this, no significant intergroup differences were generally detected between the two treatments. Accordingly, the role of ozone for the management of peri-implant mucositis deserves to be further investigated.

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An evaluation of the effect of ozone therapy on tissues surrounding dental implants

Cited by 8 publications

References 17 publications

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

Use and Applicability of Ozone Therapy in Clinical Practice in Dentistry: An Integrative Review

Ozonized Water Administration in Peri-Implant Mucositis Sites: A Randomized Clinical Trial

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