An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Hosseinkhani, Ayda; Falahatzadeh, Maryam; Raoofi, Elahe; Zarshenas, Mohammad M.

doi:10.1177/2156587216654773

Cited by 49 publications

(29 citation statements)

References 90 publications

(108 reference statements)

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“…The therapeutic value of derived plants compounds lies in their production of certain physiological actions on the organism [ 31 ]. The main compounds involved in wound healing are alkaloids, flavonoids, tannins, terpenoids, saponins, and phenolics [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

A topical ointment formulation containing leaves' powder of Lawsonia inermis accelerate excision wound healing in Wistar rats

Yassine¹,

Hemida

Mokhtar

et al. 2020

Vet World

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Aim: Lawsonia inermis (LI), a naturally grown or cultivated shrub in Northeast of Africa and India, has been traditionally used as a strong remedy for several injuries. However, few studies have reported its use as a cicatrizing agent. The aim of this study was to evaluate the effect of daily application of an ointment prepared with LI leaves' powder on wound healing in Wistar rats. Materials and Methods: Twenty female Wistar rats were used in this study. Excisional wound model was realized by removing skin from the dorsal part of the neck of each animal. Wounds have been then treated by a daily application of LI ointment prepared by mixing leaves' powder to petroleum jelly in test group and by simple application of petroleum jelly in control group. Evaluation of wound healing activity was then based on calculating the percentage of wound contraction, period of epithelialization, and wound index every 3 days for a period of 24 days, then, a histological study of the healed excised wound was performed. Results: Treatment with LI has shown excellent wound healing activity, since it has increased percent of wound contraction, and reduced period of epithelialization and wound index as compared to control (p<0.05). These results have been supported by the histological findings that revealed better epithelialization, dermal differentiation, collagen fiber orientation, and angiogenesis in LI treated rats compared to control (p<0.05). Conclusion: We can conclude that LI leaves' can be used as a potential wound healing agent.

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Section: Discussionmentioning

confidence: 99%

A topical ointment formulation containing leaves' powder of Lawsonia inermis accelerate excision wound healing in Wistar rats

Yassine¹,

Hemida

Mokhtar

et al. 2020

Vet World

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“…30 Anthocleista djalonensis, specie of Anthocleista and a shrub-like medicinal plant of the Gentianaceae family is widely distributed in tropical Africa, Madagascar,bn and on Comoros. 31 Anthocleista djalonensis is commonly known as a cabbage tree and produces fruits during October and November in Nigeria, but names used to describe Anthocleista species are usually derived from the areas or regions of the country in which they are found. In Nigeria, the Yorubas' called it sapo, Hausas' kwarii, okpokolo in Igbo and osuo in Bayelsa (Southern Nigeria).…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of burns wound healing ointment base of leaves and stem bark of Anthocleista djalonensis (L) extract using animal model.

Ugwu

Ezeibe²,

Nwobi³

et al. 2020

IJPER

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BACKGROUND: Burn wounds are inescapable life events especially in low income areas. Contamination of the burn wound site results in localized wound infection, hence the need for potent phytochemicals readily available for wound healing. The use of stem bark of Anthocleista djalonensis efficacy for burn wound has not been evaluated to the best of our knowledge. AIM: The study is aimed at evaluating and comparing the wound healing potential of ointment base of leaves and Stem bark of Anthocleista djalonensis on burn wounds created on wistar albino rats. METHODS: The leaves and Stem bark of Anthocleista djalonensis collected were extracted using 95%v/v methanol and phytochemical analysis conducted. Simple ointments of varying concentrations were formulated to screen for wound healing activity using the burn wound model on experimental rats grouped into six (n=4). Group 1 was treated with silver sulfadiazine cream (positive control), group 2 with ointment base (negative control), group 3 with 1% stem bark extract ointment, group 4 with 2% stem bark ointment, group 5 with 1% leave extract ointment, and group 6 with 2% leave extract ointment. All animals were anesthetized before the creation of burn wounds. Measurement was taken on day zero and the wound was left untreated for 48 hours in order to allow bacterial colonization before daily treatment of the wound for 16 days. RESULTS: The result of the phytochemical screening revealed that both extract of Anthocleista djalonensis contains flavonoids, tannins and saponins. On day 2, 1% stem bark, 2% stem bark and 1% leaf extract had 16%, 15%, and 10% wound contraction respectively which was higher than the 8.5% wound contraction of silver sulfadiazine. Also as the concentration of the extract increased, the wound healing effect also increased as seen by the percentage wound contraction on day 16 for all treatment. CONCLUSION: The findings of the study have shown that methanolic extracts of stem bark and leaf of Anthocleista djalonensis contained bioactive constituents which have burn wound healing activity. The stem bark extract showed better activity when compared with the leaf extract and also the positive control (silver sulfadiazine).

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“…Medicinal plants have been used for thousands of years, worldwide, as traditional treatments for numerous diseases. For example, 65 herbs were used in the traditional Persian medicine, a holistic system of medicine, providing valuable information on natural remedies [6]. Almost 80 % of the population of developing countries, but also economy leaders as China and India, use traditional medicine for the treatment of a wide range of diseases [7,8].…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds for Wound Healing

Georgescu¹,

Marinas²,

Popa³

et al. 2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Many plants or plant-derived compounds with high levels of antioxidants and antiinflammatory, immunomodulatory, and antimicrobial properties could be of great benefit for wound healing. Several studies have documented the use of plant extracts for the development of bioactive wound dressings. The purpose of this chapter is to give an update about the vegetal and bee products, which can be used as bioactive substances in wound dressings or in other formulations for wound healing. The adverse effects of plant and bee extracts, such as contact allergies, are also presented. In order to better exploit the huge reservoir of pharmacologically active plant-derived compounds and extracts, standardized methodology and clinical trials are necessary to give more concrete evidence supporting the use of traditional medicine in wound management.

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An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Cited by 49 publications

References 90 publications

A topical ointment formulation containing leaves' powder of Lawsonia inermis accelerate excision wound healing in Wistar rats

A topical ointment formulation containing leaves' powder of Lawsonia inermis accelerate excision wound healing in Wistar rats

Preparation and evaluation of burns wound healing ointment base of leaves and stem bark of Anthocleista djalonensis (L) extract using animal model.

Natural Compounds for Wound Healing

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