An evidence summary of Paediatric COVID-19 literature

Boast, Alison; Goldstein, Henry

doi:10.31440/dftb.24063

Cited by 27 publications

(25 citation statements)

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“…Specifically, in children who form just 2% of infected patients worldwide [16] their role in transmission of the disease remains controversial, with conflicting evidence as to whether or not they contribute significantly [17][18][19][20][21]. In our study, only one of the children coming in for a procedure was classified as high risk, and was still eventually found to be negative.…”

Section: Discussionmentioning

confidence: 85%

Early experience with universal preoperative and pre-procedural screening for COVID-19 in low-risk pediatric surgical patients requiring general anesthesia

2020

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Purpose The COVID-19 pandemic has placed extraordinary demands on healthcare services worldwide. Some have reported increased viral transmission to healthcare workers during aerosol-generating procedures such as intubation. We report our experience with universal preoperative and preprocedural screening for COVID-19 in children requiring general anaesthesia with low risk of having the infection. Methods This was a data review involving children aged < 18 years undergoing procedures under general anaesthesia in our institution from 18th March to 31st May 2020 and deemed low risk for COVID 19 infection, as defined by our institutional protocol. Confirmation of COVID-19 was by real time reverse-transcription polymerase chain reaction with confirmation by nucleic acid sequencing. All patients were followed up 14 days post-swab. Results Of the 66 children (median age 4.5 years, range 0-16.8) eligible for the study, 39 (60%) were male and infants (1-12 months) formed the largest group (n = 24, 36%). None were positive for COVID-19. On 14 day follow-up, none had symptoms related to COVID-19. Conclusion Our study shows that low risk asymptomatic children with no history of contact with COVID-19 patients test negative on universal screening. Larger studies are required to ascertain the role of screening prior to procedures done under general anaesthesia.

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Section: Discussionmentioning

confidence: 85%

Early experience with universal preoperative and pre-procedural screening for COVID-19 in low-risk pediatric surgical patients requiring general anesthesia

2020

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“…Current evidence suggests that children are less likely to succumb to infection, accounting for 1-8% of all COVID-19 cases. 9 , 13 , 14 There is, however, an increased morbidity in infants and young children, when compared to older children, as well as in children with a complex medical background. 13 While neonatal cases have been reported, there is no sign of breast milk transmission, 4 but there are reports of possible vertical transmission.…”

Section: Pathophysiology Of Covid-19mentioning

confidence: 99%

“…9 , 13 , 14 There is, however, an increased morbidity in infants and young children, when compared to older children, as well as in children with a complex medical background. 13 While neonatal cases have been reported, there is no sign of breast milk transmission, 4 but there are reports of possible vertical transmission. 13 There is also an increased risk amongst children of the Black, Asian, and Minority Ethnic (BAME) community in the United Kingdom of both COVID-19 and the multisystem inflammatory syndrome.…”

Section: Pathophysiology Of Covid-19mentioning

confidence: 99%

“… 13 While neonatal cases have been reported, there is no sign of breast milk transmission, 4 but there are reports of possible vertical transmission. 13 There is also an increased risk amongst children of the Black, Asian, and Minority Ethnic (BAME) community in the United Kingdom of both COVID-19 and the multisystem inflammatory syndrome. 15 , 16 , 17 The latter has been called the pediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS), 18 or multisystem inflammatory syndrome in children (MIS-C).…”

Section: Pathophysiology Of Covid-19mentioning

confidence: 99%

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Cutaneous manifestations of COVID-19 in children (and adults): A virus that does not discriminate

Lavery

Thompson

2021

Clinics in Dermatology

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COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a beta coronavirus with a characteristic S-glycoprotein ‘spike’ on the cell surface. 1 Initial reports did not include cutaneous manifestations as a feature of COVID-19; however, there is a growing repertoire of reports demonstrating an array of dermatologic manifestations on the skin in children and adults. Dermatologic afflictions have been summarized into different categories several times, with the most recent analysis identifying six clinical patterns: urticaria, maculopapular-morbilliform eruption, papulovesicular exanthem, chilblain-like acral pattern, livedo reticularis-livedo racemose pattern, and purpuric ‘vasculitic’ pattern. 2 In children, the dermatologic features appear to occur before or concomitantly with other COVID-19 manifestations. Dermatologists play a key role in diagnosing patients with COVID-19 who may present for the first time unwittingly exhibiting early signs of COVID-19. We have reviewed the current evidence on the dermatologic impact of COVID-19 in both the adult and pediatric population.

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“…To the Editor: COVID-19 has become the most significant pandemic of this era. Although adults and the elderly are most severely affected, children and neonates have been affected to a lesser extent [1]. Studies on pregnant mothers with COVID-19 published until date have shown limited evidence supporting vertical transmission [2].…”

mentioning

confidence: 99%