An evolutionary-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in<i>Hydra</i>

Vogg, Matthias Christian; Beccari, Léonardo; Olle, Laura Iglesias; Rampon, Christine; Vriz, Sophie; Perruchoud, Chrystelle; Wenger, Yvan; Galliot, Brigitte

doi:10.1101/265785

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“…Formation of organizers, also at work during developmental processes of vertebrates (Joubin and Stern, 2001), is essential for regenerative processes that involve 3D reconstruction across evolution (Pfefferli and Jazwinska, 2015;Vogg et al, 2016). Two main signaling systems appear to promote organizer formation in Hydra regenerating its head: the Wnt/b-catenin signaling pathway (Hobmayer et al, 2000;Chera et al, 2009b;Lengfeld et al, 2009;Nakamura et al, 2011;Vogg et al, 2018) and the BMP/ chordin/noggin pathway (Reinhardt et al, 2004;Rentzsch et al, 2007;Chandramore et al, 2010). However the conditions that promote the transition from wound healing immediately after bisection to organizer formation is not well understood.…”

Section: Hydrozoan Polyps Regenerate Their Body By Forming Organizersmentioning

confidence: 99%

Non-developmental dimensions of adult regeneration in Hydra

Galliot

Buzgariu²,

Wenger³

2018

Int. J. Dev. Biol.

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An essential dimension of 3D regeneration in adult animals is developmental, with the formation of organizers from somatic tissues. These organizers produce signals that recruit surrounding cells and drive the restoration of the missing structures (organs, appendages, body parts). However, even in animals with a high regenerative potential, this developmental potential is not sufficient to achieve regeneration as homeostatic conditions at the time of injury need to be "pro-regenerative". In Hydra, we identified four distinct homeostatic properties that provide a pro-regenerative framework and we discuss here how these non-developmental properties impact regeneration. First, both the epithelial and the interstitial-derived cells are highly plastic along the animal body, a plasticity that offers several routes to achieve regeneration. Second, the abundant stocks of continuously self-renewing adult stem cells form a constitutive pro-blastema in the central body column, readily activated upon bisection. Third, the autophagy machinery in epithelial cells guarantees a high level of fitness and adaptation to detrimental environmental conditions, as evidenced by the loss of regeneration in animals where autophagy is dysfunctional. Fourth, the extracellular matrix, named mesoglea in Hydra, provides a dynamically-patterned environment where the molecular and mechanical signals induced by injury get translated into a regenerative process. We claim that these homeostatic pro-regenerative features contribute to define the high regenerative potential of adult Hydra.

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