An experimental investigation of the effects of chronic stress on bone-to-implant contact

Abstract

Objectives This study aimed to investigate the effects of chronic restraint stress on the osseointegration of titanium implants. Materials and Methods Twenty adult male Wistar albino rats were used in the study. After surgical insertion of titanium implants into the metaphyseal part of the tibial bone, rats were randomly divided into two groups: a control group (CNT group) and an experimental restraint stress group (RS group). In the CNT group, titanium implants were inserted surgically, and rats received no further treatment during the 47-day experimental period. In the RS group, restraint stress was applied for 3 hours per day for 45 days, beginning 2 days after implant surgery. Weight of the rats was measured prior to surgery and at the end of the study to analyze the effects of stress. At the end of the experimental period, rats were euthanized, and implants and surrounding bone tissues were used for undecalcified histological analysis. Serum cortisol levels were assessed in cardiac blood samples from the rats following centrifugation. Results Average weight of rats in the RS group was lower than that of rats in the CNT group after the experimental protocol had been completed ( P <0.05). Further, serum cortisol levels were higher in the RS group than in the CNT group ( P <0.05). There were no significant differences in bone-implant connection levels between the two groups ( P >0.05). Conclusion The data analyzed in this study suggest that chronic restraint stress did not adversely affect rats during a 45-day osseointegration period.

Evaluation of the Effects of Systemic Irisin Hormone Application on Osseointegration of Titanium Implants: An Experimental Study

“…In addition, while we can analyze a particular thin section histopathologically, we can evaluate the implant and all bone tissues around it in 3D with biomechanical analysis. Hence, biomechanical analysis was preferred in our study 1–6 …”

“…1 A). [1][2][3][4][5][6] Resorbable blast material surfaced titanium implants (Ra:1-2) (Implance Dental Implant System, AGS Medical Corporation, Istanbul, Turkiye) with a diameter of 2.5 mm and a length of 4 mm were placed in these cavities (Fig. 1B).…”

“…Certain factors adversely impact osseointegration because of their effects on the bone regeneration mechanism. in addition to factors such as the age and gender of the patient, the physical properties of the implant, the patient's smoking habit, if any, and the use of systemic drugs may also impair osseointegration between the bone and the dental implant 2–6 …”

“…in addition to factors such as the age and gender of the patient, the physical properties of the implant, the patient's smoking habit, if any, and the use of systemic drugs may also impair osseointegration between the bone and the dental implant. [2][3][4][5][6] Irisin is a C-terminally cleaved protein containing 5 transmembrane proteins of fibronectin type III (FNDC). irisin is produced mainly by skeletal muscle as a result of exercise in mice and possibly also in humans.…”

Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo

“…undecalcified specimens have been used to evaluate the histological effects of medical materials, such as implants on tissues [28]. By utilizing resin embedding, identifying microbial colonization and its products, calcium bilirubinate, and calcium palmitate crystals may be possible.…”