An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl

Ostrovskaya, L. A.; Корман, Д. Б.; Burmiy, Joanna Petrovna; Кузьмин, В. А.; Bluhterova, N. V.; Фомина, М. М.; Rikova, V. A.; Guliev, Rustam R.; Абзаева, К. А.

doi:10.1134/s0006350918030181

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…The Pt levels in blood plasma, liver, and brain samples were determined using an Xseries inductively coupled plasma mass spectrometer (ICP-MS; Thermo Scientific, Waltham, MA, USA) as described previously [39]. Sample preparation was performed via acid decomposition of the samples in an autoclave with resistive heating [40].…”

Section: Determination Of Pt Levels In Tissuesmentioning

confidence: 99%

Neuroprotective Effect of Platinum Nanoparticles Is Not Associated with Their Accumulation in the Brain of Rats

Filippov

Александрин

Ivanov

et al. 2023

JFB

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Platinum nanoparticles (nPts) have neuroprotective/antioxidant properties, but the mechanisms of their action in cerebrovascular disease remain unclear. We investigated the brain bioavailability of nPts and their effects on brain damage, cerebral blood flow (CBF), and development of brain and systemic oxidative stress (OS) in a model of cerebral ischemia (hemorrhage + temporary bilateral common carotid artery occlusion, tBCAO) in rats. The nPts (0.04 g/L, 3 ± 1 nm diameter) were administered to rats (N = 19) intraperitoneally at the start of blood reperfusion. Measurement of CBF via laser Doppler flowmetry revealed that the nPts caused a rapid attenuation of postischemic hypoperfusion. The nPts attenuated the apoptosis of hippocampal neurons, the decrease in reduced aminothiols level in plasma, and the glutathione redox status in the brain, which were induced by tBCAO. The content of Pt in the brain was extremely low (≤1 ng/g). Thus, nPts, despite the extremely low brain bioavailability, can attenuate the development of brain OS, CBF dysregulation, and neuronal apoptosis. This may indicate that the neuroprotective effects of nPts are due to indirect mechanisms rather than direct activity in the brain tissue. Research on such mechanisms may offer a promising trend in the treatment of acute disorders of CBF.

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Section: Determination Of Pt Levels In Tissuesmentioning

confidence: 99%

Neuroprotective Effect of Platinum Nanoparticles Is Not Associated with Their Accumulation in the Brain of Rats

Filippov

Александрин

Ivanov

et al. 2023

JFB

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“…Проводилось определение массы извлеченных для исследования тканей, а также разделение крови на плазму и сыворотку путем центрифугирования в течение 10 мин при 3000 об / мин. Параллельно осуществлялись исследования контрольных животных, не получавших препарат [19]. Процедура МС-ИСП определения золота в биологических материалах проводилась в соответствии с ранее описанной методикой [20].…”

Section: материалы и методыunclassified

“…Установленная величина коэффициента ОБ опухоли для аурумакрила, равная 5,93, соответствует известным значениям этого показателя для ряда других противоопухолевых препаратов, которые изменяются в пределах от 1,6 до 10,5 [19].…”

Section: таблица 2 цитотоксический эффект аурумакрила для клеток рядunclassified

Aurum Polyacrylate: The Experimental Study of the Antitumor Activity

Островская¹,

Корман²,

Блюхтерова³

et al. 2020

Rossijskij bioterapevtičeskij žurnal

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Introduction. The investigation of metal substituted organic compounds as potential antitumor drugs is one of the promising areas of research in experimental and clinical oncology.Objective. The pre-clinical study of the original antitumor drug aurum polyacrylate (aurumacryl) which belongs to such new for oncology group of compounds as polyacrylates of metals was the aim of this work.Materials and methods. Aurumacryl antitumor activity was determined as the tumor growth inhibitory effect against some of the murine solid tumors (Lewis lung carcinoma, Acatol adenocarcinoma and Ca-755 adenocarcinoma). Drug cytotoxic effect against some of the human tumor cells (Mel-Mo melanoma, A549 lung carcinoma, MCF-7 breast carcinoma, HCT116 colon adenocarcinoma) was evaluated with standard МТТ-test. The aurumacryl pharmacokinetics in tumor bearing mice (Lewis lung carcinoma) was studied. The inductively coupled plasma mass spectrometry method was used for the estimation of the aurum maintenance in the tested tissues (tumor, blood, kidneys, liver, lungs, spleen, brain).Results. The 80–90 % tumor growth inhibitory effect of aurumacryl against some solid tumors in mice had been revealed in vivo as well as the death of the 60–90 % human tumor cells of various origins in vitro. Beside this the strong decrease of the number of proliferating MCF-7 tumor cells had been shown. The distribution of aurumacryl in the body of the mice with the solid tumor had been revealed.Conclusion. On the base of the data obtained the further study of the aurumacryl as a potential antitumor agent seems rather promising.

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