An Experimental Study of the Potential Biological Effects Associated with 2-D Shear Wave Elastography on the Neonatal Brain

Li, Changtian; Li, Junlai; Cao, Xiaolin; Song, Danfei

doi:10.1016/j.ultrasmedbio.2016.02.018

Cited by 35 publications

(29 citation statements)

References 27 publications

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“…SWE also appears to be safe to perform on the neonatal brain based on early animal data. A recent study determined that there were no effects on learning and memory or histologic changes of the brain parenchyma after SWE performed on neonatal mice brains . There was some disturbance of an important pathway, after more than 30 minutes of ultrasonographic imaging, which regulates the extension of neurites during development (PI3K/AKT/mTOR pathway) based on western blot analysis of protein expression obtained from neonatal mice brains; however, it is postulated that this injury may be repaired with continued growth …”

Section: Ultrasound Elastographymentioning

confidence: 99%

“…26 There was some disturbance of an important pathway, after more than 30 minutes of ultrasonographic imaging, which regulates the extension of neurites during development (PI3K/AKT/mTOR pathway) based on western blot analysis of protein expression obtained from neonatal mice brains; however, it is postulated that this injury may be repaired with continued growth. 26 Few studies have investigated SWE in human populations. A recent study examined brain parenchyma elasticity in normal adult subjects in an attempt to establish a standard mean stiffness (normal brain parenchyma elasticity: 7.3 ± 2.1 kPa).…”

Section: Ultrasound Elastographymentioning

confidence: 99%

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Contrast‐Enhanced Ultrasound and Elastography Imaging of the Neonatal Brain: A Review

Bailey

Huisman

Jong

et al. 2017

Journal of Neuroimaging

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Neonates presenting with neurologic symptoms require rapid, noninvasive imaging with high spatial resolution and tissue contrast. Magnetic resonance imaging (MRI) is currently the most sensitive and specific imaging modality for evaluation of neurological pathology. This modality does come with several challenges in the neonatal population, namely, the need to transport a possibly critically sick neonate to the MRI suite and the necessity of the neonate to remain still for a significant length of time, occasionally requiring sedation. Cranial ultrasound has provided radiologists and clinicians with an invaluable imaging modality that allows of rapid, bedside point of care evaluation without ionizing radiation. The major drawback of cranial ultrasound is its lower sensitivity and specificity for subtle/early lesions. Contrast-enhanced ultrasound (CEUS) and elastography have the potential to improve sensitivity and specificity for a variety of neuropathology but also expand the indications for cranial ultrasound. Goal of this paper is to present and discuss CEUS and elastography for neonatal brain imaging.

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Section: Ultrasound Elastographymentioning

confidence: 99%

Section: Ultrasound Elastographymentioning

confidence: 99%

Contrast‐Enhanced Ultrasound and Elastography Imaging of the Neonatal Brain: A Review

Bailey

Huisman

Jong

et al. 2017

Journal of Neuroimaging

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“…Shear wave elastography is already widely used for other parenchymatous organs without any relevant risks [1,15]. Additionally, reliable data regarding its use in brain tissue was supplied by experimental animal studies [16]. No adverse effects have been reported in neurosurgical investigations, where the protective skull had been removed [11].…”

Section: Safety Considerationsmentioning

confidence: 99%

Differentiation Between Ischemic and Hemorrhagic Strokes – A Pilot Study with Transtemporal Investigation of Brain Parenchyma Elasticity Using Ultrasound Shear Wave Elastography

2020

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Introduction Ultrasound shear wave elastography is well established in diagnostics of several parenchymatous organs and is recommended by respective guidelines. So far, research about applications in relevant neurological conditions is missing, especially in adults. Here we aimed to examine the method for the differentiation of ischemic (IS) and hemorrhagic strokes (HS) and cerebral mass effects. Materials & Methods 50 patients with a confirmed diagnosis of HS or IS were enrolled in this prospective study. 2D shear wave elastography was performed on the ipsilateral and the contralateral side with a modified acoustic radiation force impulse (ARFI) technique (ElastPQ mode, Philips). Lesion volumetry was conducted based on computed tomography data for correlation with elastography results. Results Elastography measurements (EM) revealed a highly significant difference between IS and HS with mean values of 1.94 and 5.50 kPa, respectively (p < 0.00 001). Mean values of brain tissue on the non-affected side were almost identical (IS 3.38 (SD = 0.63); HS 3.35 (SD = 0.66); p = 0.91). With a sensitivity of 0.98 and a specificity of 0.99, a cut-off value of 3.52 kPa for discrimination could be calculated. There was a significant correlation of mass effect represented by midline shift and EM values on the contralateral side (Pearson correlation coefficient = 0.68, p < 0.0003). Conclusion Ultrasound brain parenchyma elastography seems to be a reliable sonographic method for discriminating between large IS and HS and for detecting and tracking conditions of intracerebral mass effects.

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“…However, the research team assumed that the damage could be repaired with continued growth. 51 When 2-dimensional SWE is used to evaluate the neonatal brain, the total scan time should be more carefully monitored. Brain US elastography has also shown a good safety profile.…”

Section: Safety Of Us Elastographymentioning

confidence: 99%

Progress in the Application of Ultrasound Elastography for Brain Diseases

Liao

Yang

et al. 2020

J of Ultrasound Medicine

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Ultrasound (US) can be used to evaluate the brain structure and nervous system damage. Patients with neurologic symptoms need rapid, noninvasive imaging with high spatial resolution and tissue contrast. Magnetic resonance imaging is currently the most sensitive and specific imaging method for evaluating neuropathologic conditions. This approach does present some challenges, such as the need to transport patients who may be seriously ill to the magnetic resonance imaging suite and the need for patients to remain for a considerable time. Cranial US provides a very valuable imaging method for clinicians, which can make a rapid diagnosis and evaluation without ionizing radiation. The main disadvantage of cranial US is its low sensitivity and specificity for subtle/early lesions. In recent years, with the rapid development of anatomic and functional US technology, the practicability of US diagnosis and intervention has been greatly improved. Ultrasound elastography may have the potential to improve the sensitivity and specificity of various cranial nerve conditions. Ultrasound elastography has received considerable critical attention, and an increasing number of studies have recognized its critical role in evaluating brain diseases. At present, US elastography has been applied to the evaluation of traumatic brain injury, ischemic stroke, intraoperative brain tumors, and hypoxic ischemic encephalopathy. The latest animal experiments and human clinical trial developments in the applications of US elastography for brain diseases are summarized in this review.

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An Experimental Study of the Potential Biological Effects Associated with 2-D Shear Wave Elastography on the Neonatal Brain

Cited by 35 publications

References 27 publications

Contrast‐Enhanced Ultrasound and Elastography Imaging of the Neonatal Brain: A Review

Contrast‐Enhanced Ultrasound and Elastography Imaging of the Neonatal Brain: A Review

Differentiation Between Ischemic and Hemorrhagic Strokes – A Pilot Study with Transtemporal Investigation of Brain Parenchyma Elasticity Using Ultrasound Shear Wave Elastography

Progress in the Application of Ultrasound Elastography for Brain Diseases

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