An Experimental Study on Modelling the Physical Properties of Composite Psyllium, Alginate and Chitosan Fibers Using Box-Behnken Technique

Ullah, Azeem; Ullah, Sana; Areeb, Tanzeel; Umar, Muhammad Naveed; Phan, Duy-Nam; Masood, Rashid; Yoo, Kyung-Tae

doi:10.1007/s12221-020-1277-7

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…Therefore, increased awareness of this fundamental aspect of wound care, or any trauma, is helping to develop newer strategies and approaches for therapeutic support, and innovative materials to improve the quality of human life. Injured skin can cause serious health problems such as loose thermal insulation, and issues with body fluid, electrolytes, and nutritional components in the human body [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

et al. 2022

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In this study, polyvinyl alcohol (PVA) and psyllium husk (PSH)/D-limonene electrospun meshes were produced by emulsion electrospinning for use as substrates to prevent the growth of bacteria. D-limonene and modified microcrystalline cellulose (mMCC) were preferred as antibacterial agents. SEM micrographs showed that PVA–PSH electrospun mesh with a 4% amount of D-limonene has the best average fiber distribution with 298.38 ± 62.8 nm. Moreover, the fiber morphology disrupts with the addition of 6% D-limonene. FT-IR spectroscopy was used to analyze the chemical structure between matrix–antibacterial agents (mMCC and D-limonene). Although there were some partial physical interactions in the FT-IR spectrum, no chemical reactions were seen between the matrixes and the antibacterial agents. The thermal properties of the meshes were determined using thermal gravimetric analysis (TGA). The thermal stability of the samples increased with the addition of mMCC. Further, the PVA–PSH–mMCC mesh had the highest value of contact angle (81° ± 4.05). The antibacterial activity of functional meshes against Gram (−) (Escherichia coli, Pseudomonas aeruginosa) and Gram (+) bacteria (Staphylococcus aureus) was specified based on a zone inhibition test. PPMD6 meshes had the highest antibacterial results with 21 mm, 16 mm, and 15 mm against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, respectively. While increasing the amount of D-limonene enhanced the antibacterial activity, it significantly decreased the amount of release in cases of excess D-limonene amount. Due to good fiber morphology, the highest D-limonene release value (83.1%) was observed in PPMD4 functional meshes. The developed functional meshes can be utilized as wound dressing material based on our data.

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Section: Introductionmentioning

confidence: 99%

“…There are numerous studies related to psyllium husk gel used to make fibers by wet spinning [ 6 , 7 , 43 , 44 ]. We know that studies concerning antibacterial nanofibers consisting of PVA–psyllium husk polyblends are not yet available in the literature.…”

Section: Introductionmentioning

confidence: 99%

Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

et al. 2022

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“…Table 2 gives details of the analysis. P-value (probability of null hypothesis) ≤ 0.05 indicates the statistical significance of the effect [30,31]. It is evident from Table 2 that the impact of HA concentration has a statistically significant impact on most of the responses under study, i.e., linear density, tenacity, swelling, and absorption capacity.…”

Section: Resultsmentioning

confidence: 96%

Wet-spun bi-component alginate based hydrogel fibers: Development and in-vitro evaluation as a potential moist wound care dressing

Umar

Ullah

Nawaz

et al. 2021

International Journal of Biological Macromolecules

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“…Among these techniques, wet spinning is one of the most used techniques to develop medical fibres [ 36 ]. By using wet spinning technique, fibres of PVA [ 37 ], PCL [ 38 ], chitosan and alginate [ 39 , 40 , 41 ], psyllium husk [ 42 , 43 ], cellulose [ 44 ], polylactic acid [ 45 ], silk fibroin [ 46 ], polypyrrole [ 47 ], and collagen [ 48 , 49 ] have been prepared. Due to its low cost, scalability, and reproducibility, as well as the fact that it is a safe and clean technique, interest in using the wet spinning technique for pharmaceutical and biomedical applications has increased [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications

et al. 2023

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Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.

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An Experimental Study on Modelling the Physical Properties of Composite Psyllium, Alginate and Chitosan Fibers Using Box-Behnken Technique

Cited by 12 publications

References 36 publications

Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

Development of PVA–Psyllium Husk Meshes via Emulsion Electrospinning: Preparation, Characterization, and Antibacterial Activity

Wet-spun bi-component alginate based hydrogel fibers: Development and in-vitro evaluation as a potential moist wound care dressing

Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications

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