An exploratory study of CT-guided percutaneous radiofrequency ablation for stage I thymoma

Dong, Jun; Yuan, Shinsheng; Chang, Boyang; Huang, Jinsheng; Geng, Xiaojing; Hu, Peipei; Zhang, Bei; Xia, Ling; Wu, Peihong

doi:10.1186/s40644-019-0267-8

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Other forms of treatment might be undertaken in patients with contraindications to surgical resection. While radiofrequency ablation has been shown to be effective in controlling disease in early stage thymomas [79], No data is available for use of this modality in NETTs. Moreover, for those patients in whom their NETTs are associated with Cushing's syndrome due to ectopic adrenocorticotropic hormone production, symptoms may be controlled with somatostatin analogues [7].…”

Section: Other Treatmentsmentioning

confidence: 99%

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

Lau

Cvasciuc

Simpson

et al. 2022

European Journal of Surgical Oncology

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Section: Other Treatmentsmentioning

confidence: 99%

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

Lau

Cvasciuc

Simpson

et al. 2022

European Journal of Surgical Oncology

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“…CT-guided RFA is an effective and safe method to manage osteoid osteoma, and the benefits can persist for a long time (Lassalle et al, 2017). In addition, CT-guided RFA has also been recommended in the treatment of stage I thymoma, which has few complications and minor trauma as well as good treatment outcomes (Dong et al, 2019). However, very little is understood regarding the role and mechanism of CT-guided RFA in CC therapy.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐high‐performance liquid chromatography‐tandem mass spectrometry‐based metabolomics unveils the metabolic alterations in colon cancer mice during CT‐guided radiofrequency ablation

Cai

Zhao

et al. 2023

Biomedical Chromatography

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Colon cancer (CC) is a malignancy of the digestive tract, and computed tomography (CT)-guided radiofrequency ablation (RFA) has been extensively adopted in cancer treatment. We aimed to explore the changes in fecal metabolism after CT-guided RFA in CC mice. The orthotopic CC mice received CT-guided RFA upon modeling. Subsequently, we quantified tumor volumes and weights to assess treatment efficacy. Next, because metabolomics is useful for evaluating therapeutic validity, feces were collected for metabolomics analysis. CT-guided RFA inhibited tumor growth effectively. Additionally, metabolomics results showed that the contents of bile acids and fatty acids were downregulated in CC mouse feces. Moreover, the levels of amino acids and carbohydrates were decreased while the levels of fatty acids, organic acids, phenols, pyridines and short-chain fatty acids were elevated in feces after CC mice received CT-guided RFA. Pathway enrichment analysis revealed that those differential metabolites were closely related to fatty acids degradation and synthesis.CT-guided RFA possesses a strong ability to suppress CC development in mice, accompanied by a significant increase of fatty acid content in feces. This study proposes a novel approach and target for CC treatment, which provides hope for CC patients and establishes a solid basis for future in-depth studies.

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“…Surgery is generally considered an effective treatment method ( 16 , 17 ); however, some researchers have pointed out that for some patients with thymoma, surgical treatment may not be the best treatment method ( 18 ). It has been reported that for patients with stage I thymoma according to the Masaoka-Koga staging, open surgical resection carries the risk of potential surgical damage and other complications, and CT-guided percutaneous radiofrequency treatment of stage I thymoma is related to minor trauma, fewer complications, and good treatment results ( 19 ). In patients with Masaoka-Koga stage I and II thymoma, after appropriate surgical resection, auxiliary radiation treatment has no obvious effect on outcomes ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Predicting Masaoka-Koga Clinical Stage of Thymic Epithelial Tumors Using Preoperative Spectral Computed Tomography Imaging

Qin

Man

et al. 2021

Front. Oncol.

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ObjectivesTo investigate the utility of spectral computed tomography (CT) parameters for the prediction of the preoperative Masaoka-Koga stage of thymic epithelial tumors (TETs).Materials and MethodsFifty-four patients with TETs, aged from 37 to 73 years old, an average age of 55.56 ± 9.79 years, were included in the study.According to the Masaoka-Koga staging method, there were 19 cases of stage I, 15 cases of stage II, 8 cases of stage III, and 12 cases of stage IV disease. All patients underwent dual-phase enhanced energy spectral CT scans. Regions of interest (ROIs) were defined in sections of the lesion with homogeneous density, the thoracic aorta at the same level as the lesion, the outer fat layer of the lesion, and the anterior chest wall fat layer. The single-energy CT value at 40-140 keV, iodine concentration, and energy spectrum curve of all lesion and thoracic aorta were obtained. The energy spectrum CT parameters of the lesions, extracapsular fat of the lesions, and anterior chest wall fat in stage I and stage II were obtained. The energy spectrum CT parameters of the lesions, enlarged lymph nodes and intravascular emboli in the 3 groups were obtained. The slope of the energy spectrum curve and the normalized iodine concentration were calculated.ResultsIn stage I lesions, there was a statistically significant difference between the slope of the energy spectrum curve for the lesion and those of the fat outside the lesion and the anterior chest wall in the arteriovenous phase (P<0.001, P<0.001). The energy spectrum curve of the tumor parenchyma was the opposite of that of the extracapsular fat. In stage II lesions, there was a statistically significant difference between the slope of the energy spectrum curve for the anterior chest wall and those of the lesion and the fat outside the lesion in the arteriovenous phase(P<0.001, P<0.001). The energy spectrum curve of the tumor parenchyma was consistent with that of the extracapsular fat. Distinction between stage I and II tumors be evaluated by comparing the energy spectrum curves of the mass and the extracapsular fat of the mass. The accuracy rate of is 79.4%. For stages III and IV, there was no significant difference in the slope of the energy spectrum curve of the tumor parenchyma, metastatic lymph node, and intravascular embolism (P>0.05). The energy spectrum curve of the tumor parenchyma was consistent with that of the enlarged lymph nodes and intravascular emboli. The two radiologists have strong consistency in evaluating TETs Masaoka-Koga staging, The Kappa coefficient is 0.873,(95%CI:0.768-0.978).ConclusionSpectral CT parameters, especially the energy spectrum curve and slope, are valuable for preoperative TET and can be used in preoperative staging prediction.

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An exploratory study of CT-guided percutaneous radiofrequency ablation for stage I thymoma

Cited by 4 publications

References 19 publications

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

Ultra‐high‐performance liquid chromatography‐tandem mass spectrometry‐based metabolomics unveils the metabolic alterations in colon cancer mice during CT‐guided radiofrequency ablation

Predicting Masaoka-Koga Clinical Stage of Thymic Epithelial Tumors Using Preoperative Spectral Computed Tomography Imaging

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