An exploratory study on the association between blood-based biomarkers and subacute neurometabolic changes following mild traumatic brain injury

Visser, Koen; de Koning, Myrthe E.; Ciubotariu, Diana; Kok, Marius G. J.; Sibeijn-Kuiper, Anita J.; Bourgonje, Arno R.; van Goor, Harry; van der Naalt, Joukje; van der Horn, Harm Jan

doi:10.1007/s00415-023-12146-7

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…The pathophysiology of mTBI remains poorly understood, primarily due to heterogeneity in presentation and outcome. mTBI is associated with structural abnormalities, excitotoxicity, metabolic stress, and increased inflammation 18–20 . However, much of our understanding of mTBI pathophysiology stems from more severe injuries.…”

Section: Introductionmentioning

confidence: 99%

“…While the typical prognosis of a single concussion is positive, with full recovery within 3 months 3 , approximately 15 percent of patients also experience post-concussion symptoms (PCS) that are exacerbated with repeated mTBIs 3,6,8,9 The pathophysiology of mTBI remains poorly understood, primarily due to heterogeneity in presentation and outcome. mTBI is associated with structural abnormalities, excitotoxicity, metabolic stress, and increased inflammation [10][11][12] . However, much of our understanding of mTBI pathophysiology stems from more severe injuries.…”

Section: Introductionmentioning

confidence: 99%

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Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury

Karam,

Ashfaq,

Benitez

et al. 2024

Preprint

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Traumatic brain injuries (TBI) are the seventh leading cause of disability globally with 48.99 million prevalent cases and 7.08 million years lived with diability. Approximately 80% of TBI patients are diagnosed with mild TBI (mTBI), or concussion, caused by nonpenetrating mechanical trauma to the head or body along with sudden rotational motion of the head. Major distinctions between mTBI and more severe TBI include the absence of intracranial lesions, hemorrhages, and skull fractures in mTBI. Further, there are differences in the inflammatory response based on injury severity. While some overlap of the neuroinflammatory response across TBI severities is expected, studies investigating the temporal dynamics of neuroinflammation after mTBI and the sex-dependent differences are still needed as there have been many reported sex-dependent differences in mTBI. To fully understand the inflammatory response to TBI, it is vital to assay cerebrospinal fluid (CSF), as it has been shown that CSF biomarkers such as MAP-2 enhance prognosis capabilities. The literature analyzing the CSF proteome over time after TBI is very limited, primarily due to the lack of a CSF collection method that is minimally invasive and enables serial collections. This study had three primary goals. First, we wanted to describe a method of minimally invasive serial CSF collection. The method described in this study can easily be adapted by any laboratory prepared for animal studies. Second, we wanted to confirm that serial collection of the CSF does not alter CSF protein levels. Of the 17 analytes we tested, 16 showed no difference between serial collection and single collection. Third, we wanted to establish a framework for assessing sex differences in neuroinflammation after a concussion. We showed that results vary based on the framing of the statistical test. However, it is evident that males experience a more robust inflammatory response to a single concussion than females.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury

Karam,

Ashfaq,

Benitez

et al. 2024

Preprint

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Neurometabolite, myo-inositol, induces conformational distortion with enhanced aggregation of Carbonic Anhydrase: Implications for altered metabolite levels in Alzheimer's disease

Ahanger,

Wani,

Zhong

et al. 2025

Journal of Molecular Structure

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NMR in living systems

Prior

2024

Nuclear Magnetic Resonance

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This chapter reviews studies published during the period of May 2023 to April 2024 that have applied magnetic resonance spectroscopy to investigate processes occurring in living systems. In Section 1, new hardware, acquisition methods and analytical processes that are applicable to in vivo investigations are presented. Studies in pre-clinical models and the clinical environment are surveyed in Sections 2 and 3, respectively. The review in both these two sections is subdivided into physiological categories, with each of these sub-divided according to the category of disease or the type of metabolic investigation.

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An exploratory study on the association between blood-based biomarkers and subacute neurometabolic changes following mild traumatic brain injury

Cited by 4 publications

References 54 publications

Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury

Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury

Neurometabolite, myo-inositol, induces conformational distortion with enhanced aggregation of Carbonic Anhydrase: Implications for altered metabolite levels in Alzheimer's disease

NMR in living systems

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