An Extended-Gate Field-Effect Transistor Applied to Resistive Divider Integrated With the Readout Circuit Using 180nm CMOS Process for Uric Acid Detection

Kuo, Po-Yu; Chen, Yung-Yu; Lai, Wei-Hao; Chang, Chun-Hung

doi:10.1109/jsen.2021.3093642

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…As equation (1) shows, the uricase catalyzes uric acid (C5H4N4O3) and water into allantoin (C5H6N4O3), carbon dioxide (CO2), and hydrogen peroxide (H2O2). Automatically, as equation ( 2) shows, H2O2 decomposed into a hydrogen ion (H + ), oxygen (O2), and an electron (e -) [30].…”

Section: B Reaction Mechanism Between the Uricase And The Uric Acidmentioning

confidence: 99%

“…Identically, in Ali's study, the nanostructure of ZnO-NFs [21] and ZnO-NWs [22] can achieve lower LOD but lower average sensitivity. In Kuo's study, the RuO2 UA sensor can be applicated to electrochemical [37] and EGFET [30] measurement. Both studies achieve array sensing windows and can analyze multiple working electrodes simultaneously.…”

Section: Comparisons Of Uric Acid Sensors Based On Different Structuresmentioning

confidence: 99%

See 1 more Smart Citation

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Yang

Chan

Chang

2023

IEEE J. Electron Devices Soc.

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This study prepared an enzymatic potentiometric uric acid sensor based on zinc oxide (ZnO) and uricase. Also, we develop a potentiometric differential measurement system. We applied Nafion, APTES, and glutaraldehyde to immobilize the enzyme and increase sensitivity to prevent enzyme leakage. Thus, the uric acid sensor was integrated into FPCB which could provide flexibility to the sensor. In the uric acid concentration range of 2 mg/dL-10 mg/dL, we analyzed the characteristics of sensors with the voltage-time measurement system, measuring the average sensitivity, linearity, response time, limit of detection (LOD), and interference effects. The modification of Nafion and uricase improved the performance of the uric acid sensor.

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Section: B Reaction Mechanism Between the Uricase And The Uric Acidmentioning

confidence: 99%

Section: Comparisons Of Uric Acid Sensors Based On Different Structuresmentioning

confidence: 99%

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Yang

Chan

Chang

2023

IEEE J. Electron Devices Soc.

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“…This research mainly focuses on the fabrication of the on-chip sensing window and the analysis of the sensing characteristics. The EGFET resistive divider integrated with the instrumentation amplifier has been proposed by our previous work [35]. The proposed architecture of EGFET resistive divider can be used to measure different sensing characteristics of the on-chip sensing window in the future.…”

Section: A Characteristics Of the Egfet With The On-chip Sensing Windowmentioning

confidence: 99%

Analysis of CMOS Extended-Gate Field-Effect Transistor With On-Chip Window Based on Uricase/RuO₂ Sensing Film

Kuo¹,

Chen

Lai

et al. 2021

IEEE J. Electron Devices Soc.

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“…Extended-gate field-effect transistor (EGFET) sensors are considered as a promising option due to their high sensitivity, inherent signal amplification, full-on chip-circuit design, easy miniaturization, and system integration. − The interaction between the sensing electrode and the analyte will change the effective voltage between the gate and the channel and then change the source–drain current. , Currently, various types of sensors have been developed such as glucose, pH, troponin, dopamine, bacteria, cortisol stress hormone, etc. Most of them are electrochemical sensors.…”

Section: Introductionmentioning

confidence: 99%

Light-Activated Interface Charge-Alternating Interaction on an Extended Gate Photoelectrode: A New Sensing Strategy for EGFET-Based Photoelectrochemical Sensors

Huang

Liao

et al. 2023

ACS Appl. Mater. Interfaces

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Integration of extended gate field-effect transistors (EGFET) and photoelectrochemical (PEC) measurement to construct highly sensitive sensors is an innovative research field that was proven feasible by our previous work. However, it remains a challenge on how to adjust the interaction between the extended gate and the analyte and study its influence on EGFET-based PEC sensors. Herein, a new sensing strategy was proposed by a mutual electrostatic interaction. Three-dimensional TiO2 and g-C3N4 core-shell heterojunction on flexible carbon cloth (TCN) was designed as the extended sensing gate. Tetracycline (TC) was also used as a model analyte, and it contains electron-donating groups (-NH2 and -OH) with negative charge. The designed TCN-extended sensing gate was negatively charged in the dark by introducing carbon vacancies with oxygen doping in the g-C3N4 shell, while it was positively charged under illustration due to the aggregation of photogenerated holes on the surface. Therefore, a light-activated PEC sensing platform for the sensitive and selective determination of tetracycline (TC) was demonstrated. Such a PEC sensor exhibited wide linear ranges within 100 pM to 1 μM and 1–100 μM with a low detection limit of 0.42 pM. Furthermore, the sensing platform possessed excellent selectivity, good reproducibility, and stability. The proposed sensing strategy in this work can expand the paradigm for developing a light-regulated FET-based PEC sensor by mutual electrostatic interaction, and we believe that this work will offer a new perspective for the design of interface interaction in PEC devices.

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An Extended-Gate Field-Effect Transistor Applied to Resistive Divider Integrated With the Readout Circuit Using 180nm CMOS Process for Uric Acid Detection

Cited by 10 publications

References 34 publications

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Analysis of CMOS Extended-Gate Field-Effect Transistor With On-Chip Window Based on Uricase/RuO₂ Sensing Film

Light-Activated Interface Charge-Alternating Interaction on an Extended Gate Photoelectrode: A New Sensing Strategy for EGFET-Based Photoelectrochemical Sensors

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An Extended-Gate Field-Effect Transistor Applied to Resistive Divider Integrated With the Readout Circuit Using 180nm CMOS Process for Uric Acid Detection

Cited by 10 publications

References 34 publications

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Analysis of CMOS Extended-Gate Field-Effect Transistor With On-Chip Window Based on Uricase/RuO2 Sensing Film

Light-Activated Interface Charge-Alternating Interaction on an Extended Gate Photoelectrode: A New Sensing Strategy for EGFET-Based Photoelectrochemical Sensors

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Analysis of CMOS Extended-Gate Field-Effect Transistor With On-Chip Window Based on Uricase/RuO₂ Sensing Film