An Extrapolation Concentration Decision Effect Antihyperlipidemic of Aglycone Isoflavone from Biotransformation Soybean on the Fed High-Fat Diet Rats

임애경,; 정미정,; 김동우,; 홍주헌,; 정희경,; 김길수,; 김용해,; 김대익,

doi:10.3746/jkfn.2009.38.9.1167

Cited by 6 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3A). ALT and AST play important roles in the formation of amino acids in the liver, and their activity increases with HFD-induced liver damage (30,31). Increased ALT and AST activity is also associated with elevated serum cholesterol levels due to complications with bile acid production in liver disorders (32).…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet

Kim

Kwon

Choi

et al. 2016

International Journal of Molecular Medicine

View full text Add to dashboard Cite

The aim of this study was to examine the anti-obesity effects of boiled tuna extract in C57BL/6N mice with obesity induced by a high-fat diet (HFD). We determined the anti-obesity effects of boiled tuna extract (100, 200, or 400 mg/kg) on the progression of HFD-induced obesity for 10 weeks. The mice were divided into 5 groups as follows: the normal diet (ND) group (n=10); the HFD group (n=10); the mice fed HFD and 100 mg/kg boiled tuna extract group (n=10); those fed a HFD and 200 mg/kg boiled tuna extract group (n=10); and those fed a HFD and 400 mg/kg boiled tuna extract group (n=10). Changes in body weight, fat content, serum lipid levels and lipogenic enzyme levels were measured. The consumption of boiled tuna extract lowered epididymal tissue weight and exerted anti-obesity effects, as reflected by the serum glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL‑C), low-density lipoprotein cholesterol (LDL-C), insulin and leptin levels. In addition, we demonstrated changes in liver adipogenic- and lipogenic-related protein expression by western blot analysis. Boiled tuna extract downregulated the levels of the CCAAT/enhancer-binding protein α, β and δ (C/EBPα, β, δ), and peroxisome proliferator-activated receptor-γ (PPAR-γ) adipocyte marker genes. Boiled tuna extract also attenuated adipogenic and lipogenic gene expression, namely the levels of fatty acid synthase (FAS), lipoprotein lipase (LPL), acetyl-CoA carboxylase (ACC), glucose transporter type 4 (Glut4) and phosphorylated adenosine monophosphate-activated protein kinase α and β (AMPKα, β) in a dose-dependent manner. Moreover, the consumption of boiled tuna extract restored the levels of superoxide dismutase (SOD), catalase (CAT), glutamic oxaloacetic transaminase (GOT), glutamic-pyruvate transaminase (GPT), aspartate transaminase (AST) and alanine transaminase (ALT) to those of the control group. These results suggest that boiled tuna extract attenuates the progression of obesity by stimulating fatty acid oxidation through the upregulation of AMPK genes, as well as by inhibiting the synthesis of adipogenic and lipogenic enzymes. These characteristics of boiled tuna extract highlight its potential anti-obesity effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet

Kim

Kwon

Choi

et al. 2016

International Journal of Molecular Medicine

View full text Add to dashboard Cite

show abstract

“…However, levels of total cholesterol in serum samples appeared to be significantly lower in the 2 groups fed with high fat and isoflavone than in the group fed solely with high fat, suggesting an improving effect of intake of isoflavone on total cholesterol level. Besides, Lim et al [35] have reported that levels of total cholesterol and triglycerides in serum samples are reduced while levels of HDL-C in serum samples were increased in rat with induced hyperlipidemia fed with a diet containing aglycone isoflavone (at 3.5, 7, or 30 g/kg of diet in composition of the feed). Zang et al [36] took C57BL/6J mice at ages of 6 weeks and fed them with high fat diet added with isoflavone at 0.06%.…”

Section: Discussionmentioning

confidence: 99%

Effects of Isoflavone Supplementation on Lipid Profiles and Antioxidant Enzyme Activities in Growing Rats Fed High Fat Diet

Jang

Choi

2019

Clin Nutr Res

View full text Add to dashboard Cite

The purpose of this study was to investigate the effects of isoflavone on serum lipids and antioxidant enzymes activities in growing rats fed high lard diet. Twenty four female Sprague-Dawley rats (body weight 50–60 g) were divided into three groups, control, high fat (HF, lard 200 g/kg diet) and high fat + isoflavone (HFI, lard 200 g/kg diet + isoflavone 310.9 mg/kg diet) for 4 weeks. The results of study indicated that body weight gain was not different by isoflavone diet. Mean intake was significantly lower in HF group and HFI group than control group. Food efficiency ratio was significantly higher in HF group and HFI group than control group. The level of serum triglyceride and total cholesterol were significantly lower in HFI group than control group and HF group. The level of high-density lipoprotein cholesterol, was significantly higher in control group than HF group and HFI group. The level of low-density lipoprotein cholesterol was not significantly different by experimental diets, but atherogenic index (AI) was significantly lower in control group and HFI group than HF group. Contents of total cholesterol and triglyceride in liver tissues were found to be insignificant. The concentration of lipid peroxidation, malondialdehyde was significantly lower in control groups and HFI group than HF group. And antioxidant enzymes in liver tissue were not significantly different by lard and isoflavone supplemented diets. In conclusion, it seems possible that isoflavone supplemented high fat diet may produce positive results on level of serum triglyceride, serum total cholesterol, AI and concentration of malondialdyhyde.

show abstract

Isoflavone, β-Glucan Content and Antioxidant Activity of Defatted Soybean Powder by Bioconversion with Lentinula edodes

Jung¹,

Shin²,

Kim³

et al. 2016

J. Fd Hyg. Safety

View full text Add to dashboard Cite

An Extrapolation Concentration Decision Effect Antihyperlipidemic of Aglycone Isoflavone from Biotransformation Soybean on the Fed High-Fat Diet Rats

Cited by 6 publications

References 16 publications

Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet

Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet

Effects of Isoflavone Supplementation on Lipid Profiles and Antioxidant Enzyme Activities in Growing Rats Fed High Fat Diet

Isoflavone, β-Glucan Content and Antioxidant Activity of Defatted Soybean Powder by Bioconversion with Lentinula edodes

Contact Info

Product

Resources

About