An extraskeletal osteosarcoma in an aged rat.

Minato, Yoshio; Yamamura, Takaaki; Takada, Hiroshi; Kojima, Aya; Imaizumi, Kazunori; Wada, Isao; Takeshita, Masakazu; Okaniwa, Azusa

doi:10.1292/jvms1939.50.259

Cited by 9 publications

(10 citation statements)

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“…Carlton et al (1992), Charles and Turusov (1974), Ernst et al (2001), Franks et al (1973), Frith et al (1982), Highman et al (1981), Jolette et al (2006), Kavirayani et al (2012), Leininger and Riley (1990), Long et al (1993), Long and Leininger (1999b), Luz et al (1991a), Machado and Beauchene (1976), Mii et al (1988), Minato et al (1988), Nilsson and Stanton (1994), Olson and Capen (1977), Pybus and Miller (1938), Tucker (1986), Vahle et al (2002), Wadsworth (1989)…”

Section: Bonementioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth)

Fossey

Vahle

Long³

et al. 2016

J Toxicol Pathol

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is an initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the skeletal tissues and teeth of laboratory rats and mice, with color photomicrographs illustrating examples of many common lesions. The standardized nomenclature presented in this document is also available on the internet (http://www.goreni.org/). Sources of material were databases from government, academic and industrial laboratories throughout the world.

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Section: Bonementioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth)

Fossey

Vahle

Long³

et al. 2016

J Toxicol Pathol

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“…Extraskeletal osteosarcomas are rare in domestic and experimental animals (Cook et al., 1982; Minato et al., 1988; Patnaik, 1990) and also the incidence in human beings is low (Weiss and Goldblum, 2001). Compared with osteosarcoma of bone, extraskeletal osteosarcoma is rare, accounting for about only 1% of all osteosarcomas in dogs and appears to be less common in cats (Thompson and Pool, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The histological and immunohistochemical findings of the extraskeletal osteosarcomas are described. Extraskeletal osteosarcoma is a rare malignant tumour of the soft tissues in domestic animals and human beings (Patnaik, 1990; Weiss and Goldblum, 2001), and it is also rare in rodents (Minato et al., 1988). To our knowledge, the spontaneous extraskeletal osteosarcomas described here represent the first reported cases for Djungarian hamsters.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Extraskeletal Osteosarcomas of the Subcutis in Djungarian hamsters (Phodopus sungorus): Report of two cases

Madarame

Itoh

Hirose³

et al. 2004

Journal of Veterinary Medicine Series A

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Spontaneous subcutaneous extraskeletal osteosarcoma was diagnosed in the subcutaneous tissue of two Djungarian hamsters. Histologically, the tumour was characterized by multiple nests of osseous and cartilaginous components within a proliferation of pleomorphic cells. No abnormality was observed in any skeletal bones and no change suggesting tumorous growth was observed in any other sites. This is the first report of extraskeletal osteosarcomas in Djungarian hamsters.

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“…Specifically, it has been reported in the skin (mouse) 1 , subcutaneous tissue (rat) 2 , 3 , thoracic cavity (rat) 4 , abdominal wall (mouse) 5 , stomach (rat) 6 , and cecum (rat) 7 . This paper describes the first case of spontaneous extraskeletal osteosarcoma detected in the duodenum of a mouse.…”

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confidence: 99%

Spontaneous extraskeletal osteosarcoma in the duodenum of a Crlj:CD1 (ICR) mouse

et al. 2016

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Extraskeletal osteosarcoma is a very rare tumor in humans and animals. This paper describes a case of extraskeletal osteosarcoma observed in the duodenum of a male ICR mouse. Grossly, a solid mass pushing up the tunica serosa was observed in the duodenal wall. Histologically, the tumor was located in the lamina propria mucosae and tela mucosa. Neoplastic cells densely proliferated in these areas, and replaced of the normal tissue components. A small amount of osteoid and a small clump of bone tissue were observed in the area of neoplastic cell proliferation, especially in the lamina propria mucosae. Neoplastic cells consisted of atypical polygonal cells and pleomorphic spindle-shaped cells, and the former were predominant. Mitotic figures were occasionally observed. Neither invasion of vessels in the duodenum nor metastasis to distant organs was observed. There were no skeletal tumors in the body. Immunohistochemically, the neoplastic cells were positive for anti-osteocalcin, osteonectin, vimentin, and S-100 protein. Judging from these results, the present tumor was diagnosed as extraskeletal osteosarcoma. This is the first report of spontaneous extraskeletal osteosarcoma arising from the duodenum of a mouse.

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An extraskeletal osteosarcoma in an aged rat.

Cited by 9 publications

References 0 publications

Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth)

Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth)

Spontaneous Extraskeletal Osteosarcomas of the Subcutis in Djungarian hamsters (Phodopus sungorus): Report of two cases

Spontaneous extraskeletal osteosarcoma in the duodenum of a Crlj:CD1 (ICR) mouse

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