An FPSE-HPLC-PDA method for rapid determination of solar UV filters in human whole blood, plasma and urine

Locatelli, Marcello; Furton, Kenneth G.; Tartaglia, Angela; Sperandio, Elena; Ulusoy, Halil İ̇brahim; Kabir, Abuzar

doi:10.1016/j.jchromb.2019.04.028

Cited by 56 publications

(25 citation statements)

References 20 publications

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“…The developed method provides satisfactory limit of detection 0.15 ng/µL. Locatelli in 2019 [41] proposed a fabric phase sorptive extraction based method prior to high-performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) for the simultaneous extraction and analysis of six benzophenone derivative UV filters, including benzophenone (BZ), 5-benzoyl-4-hydroxy-methoxybenzenesulfonic acid (BP-4), bis(4-hydroxyphenyl)methanone (4-DHB), bis(2,4-dihydroxyphenyl)methanone (BP-2), (2,4-dihydroxybenzophenone) (BP-1), and 2,2 -dihydroxy-4-methoxybenzophenone (DHMB) in human whole blood, plasma, and urine samples. The limit of quantification was found to be 0.1 µg/mL.…”

Section: Applicationsmentioning

confidence: 93%

Fabric Phase Sorptive Extraction: A Paradigm Shift Approach in Analytical and Bioanalytical Sample Preparation

Kabir

Samanidou

2021

Molecules

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Fabric phase sorptive extraction (FPSE) is an evolutionary sample preparation approach which was introduced in 2014, meeting all green analytical chemistry (GAC) requirements by implementing a natural or synthetic permeable and flexible fabric substrate to host a chemically coated sol–gel organic–inorganic hybrid sorbent in the form of an ultra-thin coating. This construction results in a versatile, fast, and sensitive micro-extraction device. The user-friendly FPSE membrane allows direct extraction of analytes with no sample modification, thus eliminating/minimizing the sample pre-treatment steps, which are not only time consuming, but are also considered the primary source of major analyte loss. Sol–gel sorbent-coated FPSE membranes possess high chemical, solvent, and thermal stability due to the strong covalent bonding between the fabric substrate and the sol–gel sorbent coating. Subsequent to the extraction on FPSE membrane, a wide range of organic solvents can be used in a small volume to exhaustively back-extract the analytes after FPSE process, leading to a high preconcentration factor. In most cases, no solvent evaporation and sample reconstitution are necessary. In addition to the extensive simplification of the sample preparation workflow, FPSE has also innovatively combined the extraction principle of two major, yet competing sample preparation techniques: solid phase extraction (SPE) with its characteristic exhaustive extraction, and solid phase microextraction (SPME) with its characteristic equilibrium driven extraction mechanism. Furthermore, FPSE has offered the most comprehensive cache of sorbent chemistry by successfully combining almost all of the sorbents traditionally used exclusively in either SPE or in SPME. FPSE is the first sample preparation technique to exploit the substrate surface chemistry that complements the overall selectivity and the extraction efficiency of the device. As such, FPSE indeed represents a paradigm shift approach in analytical/bioanalytical sample preparation. Furthermore, an FPSE membrane can be used as an SPME fiber or as an SPE disk for sample preparation, owing to its special geometric advantage. So far, FPSE has overwhelmingly attracted the interest of the separation scientist community, and many analytical scientists have been developing new methodologies by implementing this cutting-edge technique for the extraction and determination of many analytes at their trace and ultra-trace level concentrations in environmental samples as well as in food, pharmaceutical, and biological samples. FPSE offers a total sample preparation solution by providing neutral, cation exchanger, anion exchanger, mixed mode cation exchanger, mixed mode anion exchanger, zwitterionic, and mixed mode zwitterionic sorbents to deal with any analyte regardless of its polarity, ionic state, or the sample matrix where it resides. Herein we present the theoretical background, synthesis, mechanisms of extraction and desorption, the types of sorbents, and the main applications of FPSE so far according to different sample categories, and to briefly show the progress, advantages, and the main principles of the proposed technique.

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Section: Applicationsmentioning

confidence: 93%

Fabric Phase Sorptive Extraction: A Paradigm Shift Approach in Analytical and Bioanalytical Sample Preparation

Kabir

Samanidou

2021

Molecules

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“…[13], [21], [37], [51] Remote UVC light sources are used in public environments is safe and economical to reduce environmentally transmitted diseases. [38], [39], [40], [44], [47], [48] [19], [24], [33], [36] They performed detection methods in ultraviolet light in fields such as bioanalytics or pharmacokinetics, diagnostics in diseases.…”

Section: Temas Y Funcionalidad Referencesmentioning

confidence: 99%

Analysis of UV technologies for disinfection of public areas: a systematic literature review

Alvarado-Miranda

Zea-Palomino

Cabanillas-Carbonell

2020

2020 IEEE Engineering International Research Conference (EIRCON)

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At present we live a health problem because of the Covid-19, therefore the study carried out is a systematic review of the different technological UV alternatives that have been developed to reduce the spread of Covid-19 and other pathogens harmful to health, since it has been proven that the UV-C range which is considered to have a very powerful radiation. In the present investigation 34 scientific articles were synthesized, taken from databases such as: Scopus/Elsevier, ScienceDirect, IEEE Xplore, Researchgate. Of these, 39% are oriented towards the health area and 21% are used in the disinfection of public areas. In conclusion, the rates of use of this germicide and how to sterilize by means of ultraviolet radiation were announced.

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“…In this work, following our previous work on whole blood and non-conventional matrices [16][17][18][19][20][21] was validated a new, fast, high-throughput, and reproducible GC-FID assay for the evaluation of the ethanol concentration in blood and vitreous humor. The purpose was to highlight that the new method is a valid and validated alternative to other procedures, confirming the correlation between these different specimens, as reported in literature [22][23][24][25], that allow estimating blood alcohol concentrations when blood is unavailable or contaminated or in cases where blood analysis cannot be carried out.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

et al. 2020

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Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical and forensic toxicology. Based on several reports, excessive alcohol consumption is the main contributing factor in traffic accidents, drownings, suicides, and other crimes. For these reasons, it becomes essential to analyze the alcohol concentration during autopsy. Although blood is usually used for alcohol analysis in post-mortem cases, it could suffer alterations, putrefaction, and microbial contaminations. As an alternative to whole blood, vitreous humor has been successfully used in medico-legal studies. In this work, post-mortem specimens were analyzed for ethanol determination. The analysis of blood and vitreous humor were carried-out using gas chromatography-flame ionized detector (GC-FID) with a total run time of 6 min. The method was validated in terms of limit of detection, limit of quantification, dynamic range, sensibility, recovery, precision and trueness. A linear regression analysis indicated a coefficient of determination (R2) of 0.9981. The study confirmed no statistically differences between alcohol concentration in blood and vitreous humor, leading vitreous humor as an excellent matrix that could be used as an alternative to whole blood in toxicological analysis in cases where blood is not available.

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An FPSE-HPLC-PDA method for rapid determination of solar UV filters in human whole blood, plasma and urine

Cited by 56 publications

References 20 publications

Fabric Phase Sorptive Extraction: A Paradigm Shift Approach in Analytical and Bioanalytical Sample Preparation

Fabric Phase Sorptive Extraction: A Paradigm Shift Approach in Analytical and Bioanalytical Sample Preparation

Analysis of UV technologies for disinfection of public areas: a systematic literature review

Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

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