An H+-FET-based system for on-line detection of microorganisms in waters

Cambiaso, A.; Chiarugi, S.; Grattarola, M.; Lorenzelli, Leandro; Lui, A.; Margesin, B.; Martinoia, Sergio; Zanini, V.; Zen, M.

doi:10.1016/s0925-4005(97)80004-4

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…On-line monitoring of biological parameters of waters is also a basic requirement for environmental control. A system reported by Cambiaso et al [ 68 ] monitored the presence of living micro-organisms by measuring cell-induced acidification rates with a pH-ISFET in microsamples of water using a specially designed flow-through micro-chamber. Escherichia coli was used as pattern microorganism.…”

Section: Isfets Applications In the Environmental Fieldmentioning

confidence: 99%

ISFET Based Microsensors for Environmental Monitoring

Jimenez-Jorquera

Orozco

Baldi

2009

Sensors

152

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The use of microsensors for in-field monitoring of environmental parameters is gaining interest due to their advantages over conventional sensors. Among them microsensors based on semiconductor technology offer additional advantages such as small size, robustness, low output impedance and rapid response. Besides, the technology used allows integration of circuitry and multiple sensors in the same substrate and accordingly they can be implemented in compact probes for particular applications e.g., in situ monitoring and/or on-line measurements. In the field of microsensors for environmental applications, Ion Selective Field Effect Transistors (ISFETs) have a special interest. They are particularly helpful for measuring pH and other ions in small volumes and they can be integrated in compact flow cells for continuous measurements. In this paper the technologies used to fabricate ISFETs and a review of the role of ISFETs in the environmental field are presented.

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Section: Isfets Applications In the Environmental Fieldmentioning

confidence: 99%

ISFET Based Microsensors for Environmental Monitoring

Jimenez-Jorquera

Orozco

Baldi

2009

Sensors

152

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“…In this section, the recent advances in electrochemical sensing techniques were reviewed for various applications including point-of-care diagnostics [ 90 , 91 ], biological analysis platforms and water safety [ 47 , 70 ]. Electrochemical sensors are the best candidates as the biological sensing structures to be incorporated with wireless circuitries in order to develop integrated wireless biosensors for life science applications.…”

Section: Toward Fully Integrated Cmos Based Biosensorsmentioning

confidence: 99%

Wireless Integrated Biosensors for Point-of-Care Diagnostic Applications

Ghafar-Zadeh

2015

Sensors

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Recent advances in integrated biosensors, wireless communication and power harvesting techniques are enticing researchers into spawning a new breed of point-of-care (POC) diagnostic devices that have attracted significant interest from industry. Among these, it is the ones equipped with wireless capabilities that drew our attention in this review paper. Indeed, wireless POC devices offer a great advantage, that of the possibility of exerting continuous monitoring of biologically relevant parameters, metabolites and other bio-molecules, relevant to the management of various morbid diseases such as diabetes, brain cancer, ischemia, and Alzheimer’s. In this review paper, we examine three major categories of miniaturized integrated devices, namely; the implantable Wireless Bio-Sensors (WBSs), the wearable WBSs and the handheld WBSs. In practice, despite the aforesaid progress made in developing wireless platforms, early detection of health imbalances remains a grand challenge from both the technological and the medical points of view. This paper addresses such challenges and reports the state-of-the-art in this interdisciplinary field.

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“…All the ISFET sensors used throughout this work are manufactured with a well-established technology (Cambiaso et al, 1996;Martinoia and Massobrio, 2000;Martinoia et al, 2001) by ITC-IRST (Trento, Italy). The ion sensitive field effect transistors/complementary metal nitride oxide semiconductor (ISFET/CMNOS) technology consists in a modified 4 m CMOS process with Al gate, realized on p-well substrate.…”

Section: Experimental Devicesmentioning

confidence: 99%

“…Pouthas et al, 2004;Kim et al, 2004), and/or on the detection of the intrinsic charge of molecules adsorbed onto the sensors surface (Fritz et al, 2004;Uslu et al, 2004;Sakata et al, 2005;Purushothaman et al, 2006). In literature, ISFET structures have been widely reported for several types of sensors, ranging form the more conventional for these devices pH sensors (Bergveld et al, 1998;Chin et al, 2001;Grattarolla and Massobrio, 2002;Martinoia and Massobrio, 2000;Martinoia et al, 2001), or biochemical sensors (Lauwers et al, 2001), to more exotic ones, such as sensors for detection of micro-organisms in water (Cambiaso et al, 1996), for cell population measurements (Martinoia et al, 2001), and so on. The ISFET sensitive layer is here made of silicon nitride (Si 3 N 4 ) (Siu and Cobbold, 1979).…”

Section: Introductionmentioning

confidence: 99%

“…In this work we are experimentally studying the adsorption of poly-l-lysine (PLL), double stranded DNA (dsDNA), single stranded DNA (ssDNA) onto Si 3 N 4 sensitive area of ISFETs and the hybridization kinetic of a DNA target to a probe linked to the sensitive surface. The electrical charge associated with these molecules can be evaluated by using an accurate model based on the site binding theory of Si 3 N 4 (Cambiaso et al, 1996;Grattarolla and Massobrio, 2002;Martinoia and Massobrio, 2000;Martinoia et al, 2001). Differently from other proposed models (e.g.…”

Section: Introductionmentioning

confidence: 99%

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