An image formation model for Secondary Ion Mass Spectrometry imaging of biological tissue samples

Abstract

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Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS

“…Biological tissues could lose their biomarker distribution if chemical fixation treatments are applied. By avoiding chemical fixation, ToF-SIMS analysis of biomarked tissues provides significant advantages and has been successfully used in the study of both surfaces and thin coatings [3,4,5,6,7], polymeric and biological samples [8,9,10], as well as biomarkers and cellular component distribution [11,12,13,14,15]. ToF-SIMS was widely used to obtain images of biological materials and tissues, like heart, brain, liver, etc.…”