An immunoblotting technique for complement C6 typing: Three new variants

Tokunaga, Katsushi; Yamamura, Noriko; Omoto, Keiichi

doi:10.1007/bf01876499

Cited by 11 publications

(17 citation statements)

References 10 publications

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“…The allele C6"B3 was suggested to be the fourth common allele in a western Japanese population (Nishimukai et al, 1985). Nevertheless, it seems to be rare in Chinese populations as in eastern Japanese (Tokunaga et al, 1983(Tokunaga et al, , 1984Nakamura et al, 1984b).…”

Section: Resultsmentioning

confidence: 99%

“…2. Among these allotypes six were identified as A, B, B2, B3, A21, and M91 (formerly 91), by direct comparison with Japanese control specimens (Tokunaga et al, 1983(Tokunaga et al, , 1984. A rare variant showed the bands slightly more acidic than those of B3, so it was designated as C6 B21 according to the International Nomenclature System .…”

Section: Resultsmentioning

confidence: 99%

“…It appears that the gene frequency of C6*B in Chinese is higher than that in the other populations. Interestingly, the most common allele of C6 in Chinese is C6*B, as in Japanese and Micronesian populations (Tokunaga et al, 1983(Tokunaga et al, , 1984Ranford et al, 1982). In contrast, it has been shown that C6*A is the most common allele in Caucasians (Hobart et al, 1976;Kunstmann et al, 1980;Olving et al, 1980).…”

Section: Resultsmentioning

confidence: 99%

“…The gel was photopolymerized with 0.4 ml of riboflavin solution at room temperature. Isoelectric focusing and immunoblotting were performed according to Tokunaga et al (1984).…”

Section: Methodsmentioning

confidence: 99%

“…Genetic polymorphism of the sixth component of human complement (C6) was first detected by Hobart et al (1975). Subsequent investigations on C6 in several populations have shown a high degree of allelic variation particularly among Asian-Pacific populations (Kunstmann et aL, 1980;Olving et al, 1980;Ranford et al, 1982;Tokunaga et aL, 1983Tokunaga et aL, , 1984. However, no study was reported in mainland Chinese up to now.…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms of complement C6 and C7 in two Chinese populations

et al. 1986

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SummaryGenetic polymorphisms of the complement components C6 and C7 in two Chinese populations (Beijing and Guangzhou) were investigated, using isoelectric focusing and immunoblotting technique. Three common and four rare allotypes of C6 were observed, and one of the rare allotypes was considered to be a new variant. Ten different patterns of C7 observed were classified into three homozygous and seven heterozygous phenotypes, indicating occurrence of four common and a new variant alleles. The new variants of C6 and C7 detected were designated as C6 B21 and C7 6, respectively. There was no statistically significant difference for C6 and C7 allele frequencies between the Beijing and the Guangzhou populations except for C7"4. The C7"4 frequency was shown to be significantly higher in Beijing than in Guangzhou. No significant positive association between C6 and C7 alleles was found.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The gel was photopolymerized with 0.4 ml of riboflavin solution at room temperature. Isoelectric focusing and immunoblotting were performed according to Tokunaga et al (1984).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

et al. 1986

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Human C7 polymorphism: Classification and association analysis with C6

et al. 1986

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SummaryPolymorphism of the seventh component of human complement (C7) was investigated in Japanese. Four common and one rare allotypes were observed with desialized samples. Besides three common alleles, C7"1, C7"2 and C7"4, the existence of the hypomorphic variant, C7"3, was confirmed in Japanese with a polymorphic frequency. The recently described C7"5 was found to correspond to C7"3 by comparing with reference samples. Moreover, a rare variant, tentatively named C7 7, was considered to be new. The population samples were also typed for C6. A rare variant, designated M92, was newly found. No significant associations between C6 and C7 alleles were found.

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Genetic polymorphisms of complement components C6 and C7 in Korean

Park¹,

Yanagisawa

Tokunaga

et al. 1988

Jap J Human Genet

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SummaryGenetic polymorphisms of the complement components C6 and C7 were investigated in Korean living in Seoul using isoelectric focusing and immunoblotting. Three common and four rare C6 allotypes were observed. The allele frequencies estimated were as follows: C6*A 0.433, C6*B 0.523, C6"B2 0.039, and rare alleles (M91, M92, M11 and M2) 0.005. Three C7 variants, besides a common allele, were observed with polymorphic frequencies. Two rare C7 variants, considered to be new, were also observed. The allele frequencies estimated for C7"1, C7"2, C7"3, C7"4, and rare variants (tentatively named K1 and K2) were 0.843, 0.073, 0.034, 0.048 and 0.002, respectively. The C6 and C7 allele frequencies are similar to those in Japanese and Chinese. The association analysis between C6 and C7 showed a significant negative association between C6 B and C7 4 allotypes (p < 0.02).

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An immunoblotting technique for complement C6 typing: Three new variants

Cited by 11 publications

References 10 publications

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

Genetic polymorphisms of complement C6 and C7 in two Chinese populations

Human C7 polymorphism: Classification and association analysis with C6

Genetic polymorphisms of complement components C6 and C7 in Korean

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