An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils.

Schroeder, John T.; Lichtenstein, Lawrence M.; MacDonald, Susan

doi:10.1084/jem.183.3.1265

Cited by 83 publications

(43 citation statements)

References 29 publications

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“…11,38,[40][41][42][43][44][45] A 21-kDa histamine-releasing factor, whose action appears to be IgE-dependent, is also a complete stimulus for basophil mediator release, but it is active only on basophils from approximately 50% of individuals. [46][47][48] Our study therefore not only identifies LIR7 as a novel signaling receptor on human basophils, but also identifies activation through LIR7 as the only presently identified IgE-independent complete stimulus for human For personal use only. on March 28, 2019.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

Sloane

Tedla

Awoniyi

et al. 2004

Blood

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Basophils, recruited from the blood to tissues, have been implicated by their presence in diverse allergic disorders including bronchial asthma, allergic rhinitis, and cutaneous contact hypersensitivity. We hypothesized that like other leukocytes involved in inflammatory responses, basophils would express members of the leukocyte immunoglobulin-like receptor (LIR) family of immunoregulatory molecules on their cell surface. We identified LIR7, an activating member coupled to the common Fc receptor gamma chain, and LIR3, an inhibitory member containing cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, on these cells from human peripheral blood. Cross-linking of LIR7 resulted in the concentration-dependent net release of histamine (29.8 ؎ 10.8%) and cysteinyl leukotrienes (cysLTs) (31.4 ؎ 8.7 ng/10 6 basophils) that were maximal at 30 minutes, and of interleukin-4 (IL-4) (410.2 ؎ 61.6 pg/10 6 basophils) that was maximal at 4 hours and comparable with the response initiated by cross-linking of the high-affinity receptor for immunoglobulin E (Fc⑀RI). Coligation of LIR3 to LIR7 or to Fc⑀RI by means of a second monoclonal antibody significantly inhibited net histamine release, cysLT production, and IL-4 generation. That LIR3 is profoundly counterregulatory for both adaptive and innate receptors suggests a broad role in containment of the inflammatory response. IntroductionBecause they resemble mast cells in their panel of mediators and cell surface expression of the high-affinity receptor for the Fc portion of immunoglobulin E (Fc⑀RI), peripheral blood basophils have in the past often been studied as mast cell surrogates due to the relative ease with which they can be isolated. However, basophils differ importantly from mast cells in their developmental pathway and limited supply of effector molecules. Developmentally, basophils originate and mature in the bone marrow, circulating as terminally differentiated cells, while mast cells circulate as precursors and complete their development after transendothelial migration to specific tissues. [1][2][3] Indeed, basophils bear a closer developmental relationship to eosinophils than to mast cells. 4,5 A case report documents the absence of both eosinophils and basophils in a single patient, 6 possibly secondary to destruction or dysfunction of a shared progenitor cell. Infection of Ws/Ws rats, which are deficient in mast cells due to a mutation in c-kit, with the parasite Nippostrongylus brasiliensis led to a more than 50-fold increase in peripheral blood basophils, equal to that observed in wild-type rats. 7 Basophils also appear to have a limited capacity to provide inflammatory mediators in comparison with mast cells. 8 Those currently recognized include histamine stored in preformed granules, leukotriene (LT) C 4 generated from arachidonic acid with cell activation, and interleukin (IL) 4 induced also by activation. 9 That basophils can provide IL-4 has led to the suggestion that these cells may reinforce T helper 2 (Th2) cell polarization. [10][11][12] Basop...

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Section: Discussionmentioning

confidence: 99%

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

Sloane

Tedla

Awoniyi

et al. 2004

Blood

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“…The distinction between HC and PC IgEs is reminiscent of the dichotomy found in human IgE molecules in their ability to prime basophils for the stimulation with histamine-releasing factor, a cytokine produced by macrophages and platelets: basophils bound by IgEs (termed IgE ϩ ) derived from atopic patients, but not those (termed IgE Ϫ ) from normal subjects, can release histamine and cytokines such as IL-4 and IL-13 in response to histamine-releasing factor (83,84). Structural basis for the difference between IgE ϩ and IgE Ϫ is not known yet.…”

Section: In Vivo Effects Of Ige(-ag) Stimulation and Their Implicatiomentioning

confidence: 99%

Mast Cell Survival and Activation by IgE in the Absence of Antigen: A Consideration of the Biologic Mechanisms and Relevance

Kawakami

Kitaura

2005

The Journal of Immunology

149

126

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Mast cells are not only major effector cells in allergy and host defense against parasites and bacteria but also important cellular components in other immune responses. Recent studies on the effects of monomeric IgE on mast cell survival and activation have made an impact on our view of the IgE binding to its high-affinity receptors, FcεRI. Traditionally, IgE binding to FcεRI has been considered as a passive action of “sensitization” before receptor aggregation by Ag. However, recent studies indicate that at high concentrations some monoclonal IgEs have effects on mast cells similar to or identical to those induced by IgE+Ag stimulation. These effects may be due to induction of FcεRI aggregation by these IgEs in the absence of Ag. This review will synthesize recent findings of the heterogeneity of IgEs in their ability to induce survival and activation events, their mechanisms, the potential in vivo significance of IgE-FcεRI interactions, and the implications of the mouse studies to human diseases.

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“…HRF/TCTP was initially described as a complete secretagog for histamine and IL-4 secretion from basophils of certain allergic donors. 15 Initially, it was thought that these donors had a certain type of IgE that interacted with HRF/TCTP to induce secretion. 15 However, it was subsequently demonstrated that HRF/TCTP primed HRF/TCTP non-responder (HRF/TCTP-NR) basophils for histamine release as well as IL-4 and IL-13 secretion regardless of the type of IgE.…”

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confidence: 99%

Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)–induced priming and activation of human basophils

Vonakis¹,

MacGlashan²,

Vilariño³

et al. 2008

Blood

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We previously identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5 phosphatase (SHIP) in basophils. We have also demonstrated that HRF/TCTP primes basophils to release mediators. The purpose of this study was to begin characterization of signal transduction events directly induced by HRF/TCTP and to investigate these events when HRF/TCTP is used as a priming agent for human basophil histamine release. Highly purified human basophils were examined for surface expression of bound HRF/TCTP, changes in calcium, and phosphorylation of Akt, mitogen-activated protein kinase kinase ( IntroductionTranslationally controlled tumor protein (TCTP) was originally identified in the 1980s by Brawerman's group as a tumor protein in a mouse acidic tumor and in mouse erythroleukemia. However, no function for the protein was identified. 1,2 We identified a histamine releasing factor (HRF) found in late-phase fluids from nasal lavages, bronchoalveolar lavage fluids, and skin blister fluids that directly induced histamine release from basophils isolated from a subpopulation of allergic donors. 3 We have previously published that approximately 50% of allergic donor basophils respond to HRF/TCTP. 4 This HRF was distinct from histamine release induced by monocyte chemotactic protein-1 (MCP-1), which is a potent activation stimulus of basophils from all donors. 5-7 After purification and cloning, HRF was found to be identical to TCTP, which is also known as p23. 8 This recombinant molecule was found to have the same properties as the originally described HRF derived from nasal secretions: namely, an ability to induce histamine release from selected donors. This protein is ubiquitously expressed as an intracellular protein, and homologs of HRF/TCTP have been described in parasites, including Plasmodium falciparum, Wucheria bancrofti, Brugiia malea, and Schistosoma mansinai, all of which possess mast cell/basophil histamine-releasing activity. [9][10][11] HRF/TCTP appears to have both intracellular and extracellular functions. One group identified the antiapoptotic activities of this molecule and renamed it fortilin. 12 Our group, as well as another group, has identified the interaction between HRF/TCTP and elongation factor-1␦, also known as eElongation factor 1B-␤. 13,14 Thus, HRF/TCTP may have an intracellular role in interfering with the elongation step of protein synthesis.We, as well as others, have focused on the extracellular functions of HRF/TCTP. HRF/TCTP was initially described as a complete secretagog for histamine and IL-4 secretion from basophils of certain allergic donors. 15 Initially, it was thought that these donors had a certain type of IgE that interacted with HRF/TCTP to induce secretion. 15 However, it was subsequently demonstrated that HRF/TCTP primed HRF/TCTP non-responder (HRF/TCTP-NR) basophils for histamine release as well as IL-4 and IL-13 secretion regar...

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An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils.

Cited by 83 publications

References 29 publications

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

Mast Cell Survival and Activation by IgE in the Absence of Antigen: A Consideration of the Biologic Mechanisms and Relevance

Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)–induced priming and activation of human basophils

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