An implantable optogenetic stimulator wirelessly powered by flexible photovoltaics with near-infrared (NIR) light

Jeong, Jinmo; Jung, Joon Pyo; Jung, Dongwuk; Kim, Juho; Ju, Hunpyo; Kim, Tae Il; Lee, Jongho

doi:10.1016/j.bios.2021.113139

Cited by 20 publications

(18 citation statements)

References 58 publications

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“…In a similar manner, a photovoltaic LED is able to turn light energy into electricity. Jeong et al (2021) utilized an illumination system based on a subcutaneous NIR light sensor which transforms the energy of the light into an electric current used to power an intracranially implanted LED. This enables completely wireless, constant optogenetic control of whisker movement in behaving mice ( Jeong et al, 2021 ).…”

Section: Methods Aiding Optogenetics In Neurosciencementioning

confidence: 99%

Red Light Optogenetics in Neuroscience

Lehtinen

Nokia

Takala

2022

Front. Cell. Neurosci.

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Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience. It possesses superior spatiotemporal resolution compared to the surgical, electrical, and pharmacological methods traditionally used in studying brain function. A multitude of optogenetic tools for neuroscience have been created that, for example, enable the control of action potential generation via light-activated ion channels. Other optogenetic proteins have been used in the brain, for example, to control long-term potentiation or to ablate specific subtypes of neurons. In in vivo applications, however, the majority of optogenetic tools are operated with blue, green, or yellow light, which all have limited penetration in biological tissues compared to red light and especially infrared light. This difference is significant, especially considering the size of the rodent brain, a major research model in neuroscience. Our review will focus on the utilization of red light-operated optogenetic tools in neuroscience. We first outline the advantages of red light for in vivo studies. Then we provide a brief overview of the red light-activated optogenetic proteins and systems with a focus on new developments in the field. Finally, we will highlight different tools and applications, which further facilitate the use of red light optogenetics in neuroscience.

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Section: Methods Aiding Optogenetics In Neurosciencementioning

confidence: 99%

Red Light Optogenetics in Neuroscience

Lehtinen

Nokia

Takala

2022

Front. Cell. Neurosci.

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“…Light can also be used for the wireless interface, leveraging the availability of low-cost lasers and LED. Tissue absorption can be minimized by operating within the near-infrared (NIR) window in biological tissue (650 nm to 1350 nm) [33,[58][59][60][61][62][63][64][65][66][67]146]. However, scattering generally limits the effective penetration depth to at most a centimetre.…”

Section: (E) Lightmentioning

confidence: 99%

“…The design of the external wireless interface can also take advantage of flexible and stretchable materials and design to improve comfort when worn during daily activities [206]. Flexible optical wireless interfaces can be realized using flexible photovoltaic films as optical detectors and energy harvesters [65,151,152]. In addition, flexible ultrasonic interfaces have been demonstrated using arrays of piezoelectric crystal with stretchable interconnects [145].…”

Section: Challenges and Solutionsmentioning

confidence: 99%

“…In this review, we provide an overview of recent advances in wireless interfaces for brain neurotechnologies. We introduce the requirements that modern brain-implanted devices impose on the wireless interface and discuss the working principles and relative advantages of modalities based on electromagnetic (EM) fields [32,[44][45][46][47][48][49], ultrasound [50][51][52][53][54][55][56][57] and light [33,[56][57][58][59][60][61][62][63][64][65][66][67]. We investigate major challenges for wireless interfaces based on radio-frequency and other modalities.…”

Section: Introductionmentioning

confidence: 99%

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Wireless interfaces for brain neurotechnologies

Kim

2022

Phil. Trans. R. Soc. A.

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Wireless interfaces enable brain-implanted devices to remotely interact with the external world. They are critical components in modern research and clinical neurotechnologies and play a central role in determining their overall size, lifetime and functionality. Wireless interfaces use a wide range of modalities—including radio-frequency fields, acoustic waves and light—to transfer energy and data to and from an implanted device. These forms of energy interact with living tissue through distinct mechanisms and therefore lead to systems with vastly different form factors, operating characteristics, and safety considerations. This paper reviews recent advances in the development of wireless interfaces for brain neurotechnologies. We summarize the requirements that state-of-the-art brain-implanted devices impose on the wireless interface, and discuss the working principles and applications of wireless interfaces based on each modality. We also investigate challenges associated with wireless brain neurotechnologies and discuss emerging solutions permitted by recent developments in electrical engineering and materials science. This article is part of the theme issue 'Advanced neurotechnologies: translating innovation for health and well-being'.

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“…PTICAL wireless power transfer (OWPT) is an emerging and promising approach applicable in many practical systems including internet of things [1,2], consumer electronics [1,3], implantable medical devices [4][5][6], vehicle electrification [7][8][9][10][11][12], robotics [7][8][9][10][11][12], etc. OWPT systems possess unique features that other WPT systems do not have.…”

Section: Introductionmentioning

confidence: 99%

Performance Analysis of a Perovskite-Based Thing-to-Thing Optical Wireless Power Transfer System

et al. 2022

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This paper presents an analysis on the performance of an optical wireless power transfer system in which optical transceivers made from a perovskite are used. Experiments are performed under different settings, whose resulted data reveal interesting findings. First, system performance is only matched with the existing theory when no collimating lens is employed. Hence, a data-driven mathematical model is proposed and verified when a collimating lens is used. Second, a collimating lens helps increase the amount of wirelessly transferred power and the transfer distance if perfect alignment between optical transceivers is guaranteed, but substantially limits the sliding distance between them otherwise. Index Terms-Optical wireless power transfer, bidirectional wireless power transfer, optical transceiver, perovskite solar cells, perovskite light-emitting diodes, data-driven mathematical modeling.

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An implantable optogenetic stimulator wirelessly powered by flexible photovoltaics with near-infrared (NIR) light

Cited by 20 publications

References 58 publications

Red Light Optogenetics in Neuroscience

Red Light Optogenetics in Neuroscience

Wireless interfaces for brain neurotechnologies

Performance Analysis of a Perovskite-Based Thing-to-Thing Optical Wireless Power Transfer System

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