An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine

Alves, Vinicius M.; Gonçalves, José Alberto; Conceição, Carlota; Teixeira, Helena M.; Câmara, José S.

doi:10.1016/j.chroma.2015.07.021

Cited by 35 publications

(16 citation statements)

References 43 publications

(46 reference statements)

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“…Alves, Gonçalves, Conceição, Teixeira, and Câmara () successfully determined fluoxetine concentrations in human urine by employing microextraction by packed sorbent (MEPS) for sample pretreatment. As a miniaturized version of SPE, MEPS is operated similarly as an SPE process and commonly used SPE cartridges are also commercially available for MEPS.…”

Section: Techniquesmentioning

confidence: 99%

Recent advances in liquid chromatographic methods for the determination of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors

Jia

Bartlett

2020

Biomedical Chromatography

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Depression is now the second largest public health burden throughout the world. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) have replaced older antidepressants to become first‐line medications to treat this disease with increased remission rates and markedly decreased incidence of severe adverse events. Traditional and modern bioanalytical strategies for SSRI and SNRI determination are being continuously improved. There has also been a recent increase in the use of unconventional sample preparation methods. This review critically evaluates the development of SSRI and SNRI liquid chromatographic analytical methods published between 2014 and mid‐2019, with special attention to novel sample preparation methods.

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Section: Techniquesmentioning

confidence: 99%

Recent advances in liquid chromatographic methods for the determination of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors

Jia

Bartlett

2020

Biomedical Chromatography

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“…Typically, these pharmaceutical drugs are divided into four main classes: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitor (SSRI), selective noradrenaline reuptake inhibitor (SNRI), and monoamine oxidase inhibitors (MOI) [4]. Although there are several different medicines commercially available, most of them have similar side effects (mainly in the early stages of administration), and a slow time to start acting on the human brain [5].…”

Section: Introductionmentioning

confidence: 99%

Multidimensional Liquid Chromatography Employing a Graphene Oxide Capillary Column as the First Dimension: Determination of Antidepressant and Antiepileptic Drugs in Urine

et al. 2020

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Human mental disorders can be currently classified as one of the most relevant health topics. Including in this are depression and anxiety, which can affect us at any stage of life, causing economic and social problems. The treatments involve cognitive psychotherapy, and mainly the oral intake of pharmaceutical antidepressants. Therefore, the development of analytical methods for monitoring the levels of these drugs in biological fluids is critical. Considering the current demand for sensitive and automated analytical methods, the coupling between liquid chromatography and mass spectrometry, combined with suitable sample preparation, becomes a useful way to improve the analytical results even more. Herein we present an automated multidimensional method based on high-performance liquid chromatography-tandem mass spectrometry using a lab-made, graphene-based capillary extraction column connected to a C8 analytical column to determined five pharmaceutical drugs in urine. A method enhancement was performed by considering the chromatographic separation and the variables of the loading phase, loading time, loading flow, and injection volume. Under optimized conditions, the study reports good linearity with R2 > 0.98, and limits of detection in the range of 0.5–20 µg L−1. Afterward, the method was applied to the direct analysis of ten untreated urine samples, reporting traces of citalopram in one of them. The results suggest that the proposed approach could be a promising alternative that provides direct and fully automated analysis of pharmaceutical drugs in complex biological matrices.

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“…10 FLX is a halogenated compound and studies show that through human metabolism, o-dealkylation of FLX promotes the formation of the trihalogenated compound 4-(trifluoromethyl)phenol (TFMP). 21 The TPs resulting from the degradation of FLX have been identified and quantified through various analytical techniques, 10,15,[22][23][24] on account of this it can be considered an essential step to define the true kinetic behavior of FLX degradation.…”

Section: Introductionmentioning

confidence: 99%

“…6,10 The TPs formed can influence the degradation of the original compound and their monitoring allows for advances in the kinetic understanding of FLX degradation. 19,23 It is also worth noting that the definition of the mechanisms of degradation and the influence of different energies applied to advanced oxidative processes are of scientific interest.…”

Section: Introductionmentioning

confidence: 99%

Photodegradation of Fluoxetine Applying Different Photolytic Reactors: Evaluation of the Process Efficiency and Mechanism

Moreira¹,

Borges²,

Sousa³

et al. 2018

J. Braz. Chem. Soc.

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Photolytic degradation of fluoxetine (FLX), a medicine commonly known as Prozac ® , was evaluated by using different photochemical processes. The ultraviolet/microwave (UV/MW) process showed higher efficiency in all the aspects evaluated in this study. The energy consumption was equivalent to 1.94 × 10-4 kW h mg-1 L (UV/MW), while in the UV process the value was 1.20 × 10-2 kW h mg-1 L. The degradation kinetics were applied to the FLX, with rate constant (k) = 0.15 ± 0.01 min-1 and linear correlation coefficient (R 2) = 0.980 for UV, and k = 6.15 ± 0.08 min-1 and R 2 = 0.998 for UV/MW. The FLX degradation of 99.16% (UV/MW 5 min) and 98.90% (UV 120 min) were observed, evidencing higher efficiency for the first process. The monitoring of transformation products (TPs) through chromatographic analysis enabled the identification of 9 TPs, proving that for the UV/MW process, the hydroxylated structures are verified in high quantity.

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An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine

Cited by 35 publications

References 43 publications

Recent advances in liquid chromatographic methods for the determination of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors

Recent advances in liquid chromatographic methods for the determination of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors

Multidimensional Liquid Chromatography Employing a Graphene Oxide Capillary Column as the First Dimension: Determination of Antidepressant and Antiepileptic Drugs in Urine

Photodegradation of Fluoxetine Applying Different Photolytic Reactors: Evaluation of the Process Efficiency and Mechanism

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