An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging

Firbank, Michael; Oda, Masaomi; Delpy, David T.

doi:10.1088/0031-9155/40/5/016

Cited by 170 publications

(122 citation statements)

References 14 publications

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“…In addition, our technique offers other possibilities. With Mie theory, it would be possible to predict the absorption, scattering and anisotropy coefficients of the phantoms based on the refractive indices and the size of the microspheres with a good agreement (Sukowski et al 1996, Firbank et al 1995. To do so, a more precise evaluation of the refractive index of the microspheres is needed.…”

Section: Discussionmentioning

confidence: 99%

Deformable and durable phantoms with controlled density of scatterers

et al. 2008

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We have developed deformable and durable optical tissue phantoms with a simple and well-defined microstructure including a novel combination of scatterers and a matrix material. These were developed for speckle and elastography investigations in optical coherence tomography, but should prove useful in many other fields. We present in detail the fabrication process which involves embedding silica microspheres in a silicone matrix. We also characterize the resulting phantoms with scanning electron microscopy and optical measurements. To our knowledge, no such phantoms were proposed in the literature before. Our technique has a wide range of applicability and could also be adapted to fabricate phantoms with various optical and mechanical properties.

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Section: Discussionmentioning

confidence: 99%

Deformable and durable phantoms with controlled density of scatterers

et al. 2008

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“…The peaks in the absorption spectrum around 900 nm stems from the epoxy. Below 800 nm, the epoxy absorption has been reported to be fairly flat at 0.01 cm -1 , 9 so most of the absorption in this region is due to the black pigment. The determined values of µ a and µ s ' for both systems, at 660 nm, are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A set of 25 phantoms was prepared from clear, solvent-free epoxy resin (NM 500, Nils Malmgren AB, Ytterby, Sweden), according to the guidelines given by Firbank et al 8,9 . As scatterer, TiO powder was used (Sigma-Aldrich, T-8141).…”

Section: Solid Tissue Phantomsmentioning

confidence: 99%

Rigorous characterization of time-resolved diffuse spectroscopy systems for measurements of absorption and scattering properties using solid phantoms

Swartling

Pifferi

Giambattistelli

et al. 2003

Photon Migration and Diffuse-Light Imaging

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Two systems for measurements of absorption and scattering properties, based on picosecond-pulse lasers and singlephoton counting detection, were characterized using a detailed protocol. The first system utilizes diode lasers at 660, 785, 910 and 974 nm as light sources. The second employs a Ti:sapphire and a mode-locked dye laser to produce tunable pulses in the range 610 -1000 nm. Using solid tissue phantoms, the systems were rigorously characterized and compared in terms of absolute accuracy of the measured scattering and absorption coefficients, the linearity over the parameter range, the precision with respect to injected light energy, the stability over time, and the reproducibility of the results. The phantoms were made of epoxy resin with TiO as scatterer and black toner powder as absorber.

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“…4) with TiO 2 particles is about 0.5 and with latex microspheres about 0.9, which is closer to that of tissue. (Firbank et al, 1993(Firbank et al, , 1995.…”

Section: Phantoms For Diffuse Optical Imagingmentioning

confidence: 99%

Diffuse Optical Imaging

Nissilä

Noponen

Heino

et al.

Advances in Electromagnetic Fields in Living Systems

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Diffuse optical imaging is a functional medical imaging modality which takes advantage of the relatively low attenuation of near-infrared light to probe the internal optical properties of tissue. The optical properties are affected by parameters related to physiology such as the concentrations of oxy-and deoxyhemoglobin. Instrumentation that is used for optical imaging is generally able to measure changes in the attenuation of light at several wavelengths, and in the case of time-and frequency-domain instrumentation, the time-of-flight of the photons in tissue.Light propagation in tissue is generally dominated by scattering. Models for photon transport in tissue are generally based on either stochastic approaches or approximations derived from the radiative transfer equation. If a numerical forward model which describes the physical situation with sufficient accuracy exists, inversion methods may be used to determine the internal optical properties based on boundary measurements.Optical imaging has applications in, e.g., functional brain imaging, breast cancer detection, and muscle imaging. It has the important advantages of transportable instrumentation, relatively high tolerance for external electromagnetic interference, non-invasiveness, and applicability for neonatal studies. The methods are not yet in clinical use, and further research is needed to improve the reliability of the experimental techniques, and the accuracy of the models used. In this chapter, we describe the interaction between light and tissue, light propagation models and inversion methods used in optical tomography, and instrumentation and experimental techniques used in optical imaging. The main applications of optical imaging are described in detail, with results from recent literature.

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An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging

Cited by 170 publications

References 14 publications

Deformable and durable phantoms with controlled density of scatterers

Deformable and durable phantoms with controlled density of scatterers

Rigorous characterization of time-resolved diffuse spectroscopy systems for measurements of absorption and scattering properties using solid phantoms

Diffuse Optical Imaging

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