An Improved Monkey Model of Myocardial Ischemic Infarction for Cardiovascular Drug Development

Wang, Keke; Han, Ping; Huang, Lu; Xiao, Ying; Hou, Jianglong; Yang, Ping; Xie, Yuping; Cai, Jindan; Wang, Hongge; Kang, Yu

doi:10.1007/s12012-022-09754-6

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…The distribution of the heart and coronary arteries in rhesus monkeys is highly similar to humans, making them one of the best choices for preparing models of MI ( 87 , 88 ). Studies generally construct MI models by ligating the left anterior descending coronary artery in 2-3 year old rhesus monkeys ( 88 , 89 ). One study has used the gene-edited pig heart and xenotransplant it into a baboon, managing the severe immune rejection that occurs with xenotransplants and keeping the baboon alive for more than two years ( 90 ).…”

Section: Animals Model Of MImentioning

confidence: 99%

The role of major immune cells in myocardial infarction

Feng

Zhou

et al. 2023

Front. Immunol.

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Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, often leading to adverse cardiac remodeling and heart failure, which is a serious threat to human life and health. The immune system makes an important contribution to the maintenance of normal cardiac function. In the disease process of MI, necrotic cardiomyocytes release signals that activate nonspecific immunity and trigger the action of specific immunity. Complex immune cells play an important role in all stages of MI progression by removing necrotic cardiomyocytes and tissue and promoting the healing of damaged tissue cells. With the development of biomaterials, cardiac patches have become an emerging method of repairing MI, and the development of engineered cardiac patches through the construction of multiple animal models of MI can help treat MI. This review introduces immune cells involved in the development of MI, summarizes the commonly used animal models of MI and the newly developed cardiac patch, so as to provide scientific reference for the accurate diagnosis and effective treatment of MI.

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Section: Animals Model Of MImentioning

confidence: 99%

The role of major immune cells in myocardial infarction

Feng

Zhou

et al. 2023

Front. Immunol.

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show abstract

“…In addition to helping to discover the pathogenesis, animal models have also made great contributions to the development of medicines for treating human diseases. A case in point here is the cardiovascular drug is developed from a monkey model [ 11 ]. Similarly, researchers believe animal models are of positive significance for the development of COVID-19 clinical medicines.…”

Section: Introductionmentioning

confidence: 99%

A generalized classification and coding system of Human Disease Animal Model Resource data with a case study to show improving database retrieval efficiency

Huiping

Zhang

2023

PLoS ONE

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Background Currently there is no unified data classification and coding standard for the existing human disease animal model resource data worldwide. Different data classification and coding systems produce different retrieval methods. Some of these methods are inefficient and difficult to use. This research investigated the rules for the classification and coding of such data based on the Replication Methodology of Animal Models for Human Disease, the Classification and Coding Rules for Health Information Data Set (WS/T 306–2009), the Science and Technology Resource Identification (GB/T 32843–2016), the Scientific Data Management Measures (000014349/2018-00052), and The Generic Description Specification for Natural Science and Technology Resources. This research aimed to develop a classification and coding system for data obtained from human disease animal model resource based on the Internet environment to provide a standardized and unified foundation for the collection, saving, retrieval, and sharing of data from this resource. Results A complete data classification and coding table compiled in the form of letters and numbers was produced, with a classification infrastructure that expanded layer by layer according to the three dimensions (namely, system diseases, animal species, and modeling methods) and essential attributes. When necessary, it adopted the hierarchy of major, intermediate, and minor categories for certain layer and also one-to-one matched the code and classification result. Conclusion Through this study, a sharing and joint construction mechanism for data from this resource can be developed by all research institutes in this field. As a case study, this research also offered technical support for constructing the database for the National Human Disease Animal Model Resource Center. The technological innovation of this paper is to derive a research oriented retrieval method, which provides technical support for the research on the current COVID-19 epidemic and on possible future epidemics.

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