An in vitro study shows the potential of Nostoc commune (Cyanobacteria) polysaccharides extract for wound-healing and anti-allergic use in the cosmetics industry

Tseng, Chung‐Chih; Yeh, Han–Yang; Liao, Zhen-Hao; Hung, Sheng-Wen; Chen, Boryuan; Lee, Po‐Tsang; Nan, Fan-Hua; Shih, Wen‐Ling; Chang, Chia-Ching; Lee, Meng–Chou

doi:10.1016/j.jff.2021.104754

Cited by 31 publications

(14 citation statements)

References 43 publications

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“…PE 14 [ 149 ] or by Cyanobacterium aponinum [ 150 ] was also demonstrated in animal and human cell lines. N. commune extract resulted in being effective in downregulating IL-6 [ 151 ] and is, therefore, potentially useful for anti-allergic and wound-healing therapeutic purposes [ 152 ].…”

Section: Polysaccharides From Cyanobacteria For Developing New Bioact...mentioning

confidence: 99%

Microalgae-Based Biorefineries: Challenges and Future Trends to Produce Carbohydrate Enriched Biomass, High-Added Value Products and Bioactive Compounds

Olguín

Sánchez-Galván

Arias‐Olguín³

et al. 2022

Biology

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Microalgae have demonstrated a large potential in biotechnology as a source of various macromolecules (proteins, carbohydrates, and lipids) and high-added value products (pigments, poly-unsaturated fatty acids, peptides, exo-polysaccharides, etc.). The production of biomass at a large scale becomes more economically feasible when it is part of a biorefinery designed within the circular economy concept. Thus, the aim of this critical review is to highlight and discuss challenges and future trends related to the multi-product microalgae-based biorefineries, including both phototrophic and mixotrophic cultures treating wastewater and the recovery of biomass as a source of valuable macromolecules and high-added and low-value products (biofertilizers and biostimulants). The therapeutic properties of some microalgae-bioactive compounds are also discussed. Novel trends such as the screening of species for antimicrobial compounds, the production of bioplastics using wastewater, the circular economy strategy, and the need for more Life Cycle Assessment studies (LCA) are suggested as some of the future research lines.

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Section: Polysaccharides From Cyanobacteria For Developing New Bioact...mentioning

confidence: 99%

Microalgae-Based Biorefineries: Challenges and Future Trends to Produce Carbohydrate Enriched Biomass, High-Added Value Products and Bioactive Compounds

Olguín

Sánchez-Galván

Arias‐Olguín³

et al. 2022

Biology

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“…In fact, a wide variety of bioactivities have been described for these compounds. Some examples are antihyperlipidemic [ 10 ], antiobesity [ 11 ], antidiabetic [ 12 ], antioxidant [ 5 , 6 ], anti-inflammatory [ 13 ], antiviral [ 14 ], antibacterial [ 15 ], antitumoral [ 13 ], antiallergic [ 16 ], and neuroprotective [ 17 ]. Hence, cyanobacteria have gained interest as a possible source of phytochemicals with wide-ranging practical uses.…”

Section: Introductionmentioning

confidence: 99%

Naturally Occurring Functional Ingredient from Filamentous Thermophilic Cyanobacterium Leptolyngbya sp. KC45: Phytochemical Characterizations and Their Multiple Bioactivities

et al. 2022

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Cyanobacteria are rich in phytochemicals, which have beneficial impacts on the prevention of many diseases. This study aimed to comprehensively characterize phytochemicals and evaluate multifunctional bioactivities in the ethanolic extract of the cyanobacterium Leptolyngbya sp. KC45. Results found that the extract mainly contained chlorophylls, carotenoids, phenolics, and flavonoids. Through LC–ESI–QTOF–MS/MS analysis, 38 phenolic compounds with promising bioactivities were discovered, and a higher diversity of flavonoids was found among the phenolic compounds identified. The extract effectively absorbed the harmful UV rays and showed high antioxidant activity on DPPH, ABTS, and PFRAP. The extract yielded high-efficiency inhibitory effects on enzymes (tyrosinase, collagenase, ACE, and α-glucosidase) related to diseases. Interestingly, the extract showed a strong cytotoxic effect on cancer cells (skin A375, lung A549, and colon Caco-2), but had a much smaller effect on normal cells, indicating a satisfactory level of safety for the extract. More importantly, the combination of the DNA ladder assay and the TUNEL assay proved the appearance of DNA fragmentation in cancer cells after a 48 h treatment with the extract, confirming the apoptosis mechanisms. Our findings suggest that cyanobacterium extract could be potentially used as a functional ingredient for various industrial applications in foods, cosmetics, pharmaceuticals, and nutraceuticals.

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“…Polysaccharide extracts from algae have also been evaluated to determine their wound healing properties. For instance, Tseng et al [ 55 ] demonstrated that a polysaccharide extract from Nostoc commune significantly increased the production of type I collagen (from 0.59 to 1.08 ng/mL) in a concentration-dependent manner (0–5 mg/mL) by a human skin fibroblast cell line (CCD-966SK). Moreover, the extract at 0.0625–1.0 mg/mL significantly reduced the levels of IL-6 in a LPS-challenged RAW 264.7 murine macrophage cell line.…”

Section: In Vitro Studies On the Effect Of Natural Products On Wound ...mentioning

confidence: 99%

“…The extract contained polysaccharides (221.69 mg/g), sulfates (156.11 mg/g), flavonoids (2.93 mg/g), and phenolic compounds (0.37 mg/g). These results suggest that the polysaccharide extract of Nostoc commune exerts effects as a wound healing and anti-inflammatory agent with the potential for application in the cosmetic industry [ 55 ].…”

Section: In Vitro Studies On the Effect Of Natural Products On Wound ...mentioning

confidence: 99%

Wound Healing Properties of Natural Products: Mechanisms of Action

et al. 2023

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A wound is the loss of the normal integrity, structure, and functions of the skin due to a physical, chemical, or mechanical agent. Wound repair consists of an orderly and complex process divided into four phases: coagulation, inflammation, proliferation, and remodeling. The potential of natural products in the treatment of wounds has been reported in numerous studies, emphasizing those with antioxidant, anti-inflammatory, and antimicrobial properties, e.g., alkaloids, saponins, terpenes, essential oils, and polyphenols from different plant sources, since these compounds can interact in the various stages of the wound healing process. This review addresses the most current in vitro and in vivo studies on the wound healing potential of natural products, as well as the main mechanisms involved in this activity. We observed sufficient evidence of the activity of these compounds in the treatment of wounds; however, we also found that there is no consensus on the effective concentrations in which the natural products exert this activity. For this reason, it is important to work on establishing optimal treatment doses, as well as an appropriate route of administration. In addition, more research should be carried out to discover the possible side effects and the behavior of natural products in clinical trials.

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An in vitro study shows the potential of Nostoc commune (Cyanobacteria) polysaccharides extract for wound-healing and anti-allergic use in the cosmetics industry

Cited by 31 publications

References 43 publications

Microalgae-Based Biorefineries: Challenges and Future Trends to Produce Carbohydrate Enriched Biomass, High-Added Value Products and Bioactive Compounds

Microalgae-Based Biorefineries: Challenges and Future Trends to Produce Carbohydrate Enriched Biomass, High-Added Value Products and Bioactive Compounds

Naturally Occurring Functional Ingredient from Filamentous Thermophilic Cyanobacterium Leptolyngbya sp. KC45: Phytochemical Characterizations and Their Multiple Bioactivities

Wound Healing Properties of Natural Products: Mechanisms of Action

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