An In Vivo Method for Measuring the Mechanical Properties of the Skin Using Ultrasound

Diridollou, S.; Berson, M.; Vabre, V.; Black, David R.; Karlsson, Bengt; Auriol, Françoise; Grégoire, Jean‐Marc; Yvon, C.; Vaillant, L.; Gall, Y.; Patat, F.

doi:10.1016/s0301-5629(97)00237-8

Cited by 125 publications

(91 citation statements)

References 32 publications

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“…In contrast, mildly photoaged skin appears roughened and deeply wrinkled and is characterised histologically by the loss of fibrillin microfibrils (Watson et al 1999) and fibulin (Kadoya et al 2005) from the papillary dermis. In severely photoaged skin, however, abundant deposits of highly disorganised, elastic fibre material are distributed throughout the dermis (Warren et al 1991;Watson et al 2001;Werth et al 1996;Yaar and Gilchrest 2007) Early attempts to quantify the effects of ageing on the mechanical properties of skin were hampered by: the use of terminology which was open to misinterpretation (Doubal and Klemera 2002), the diversity of both mechanical tests (Diridollou et al 1998;Rodrigues 2001) and anatomical sites (Escoffier et al 1989), and most importantly by the heterogeneity and anisotropy of the skin layers themselves (Diridollou et al 1998;Pierard 1999). The mechanical response of skin to the application of tensile and torsional forces and to deformations induced by indentation and suction have all been reported in the literature (see Rodrigues 2001 for an excellent review).…”

Section: Cutaneousmentioning

confidence: 99%

“…4c) are perhaps the most widely used (Diridollou et al 1999;Pierard 1999;Rodrigues 2001;Smalls et al 2006;Takema and Imokawa 1998;Takema et al 1994). Diridollou and co-workers suggest that this technique enables the measurement of mechanical responses which originate primarily from the dermis rather than subcutaneous structures (Diridollou et al 1998). Commercially developed devices include the Cutometer, which measures skin deformations optically, and the Dermaflex A, which measures vertical skin displacements by changes in capacitance (Diridollou et al 1998;Smalls et al 2006 biomechanical properties measured by these techniques requires quantitation of skin thickness.…”

Section: Cutaneousmentioning

confidence: 99%

“…Diridollou and co-workers suggest that this technique enables the measurement of mechanical responses which originate primarily from the dermis rather than subcutaneous structures (Diridollou et al 1998). Commercially developed devices include the Cutometer, which measures skin deformations optically, and the Dermaflex A, which measures vertical skin displacements by changes in capacitance (Diridollou et al 1998;Smalls et al 2006 biomechanical properties measured by these techniques requires quantitation of skin thickness. Early attempts to measure skin thickness using callipers ) have largely been superseded by the use of ultrasound (Diridollou et al 1999;Escoffier et al 1989;Takema et al 1994).…”

Section: Cutaneousmentioning

confidence: 99%

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Tissue elasticity and the ageing elastic fibre

Sherratt

2009

AGE

270

189

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The ability of elastic tissues to deform under physiological forces and to subsequently release stored energy to drive passive recoil is vital to the function of many dynamic tissues. Within vertebrates, elastic fibres allow arteries and lungs to expand and contract, thus controlling variations in blood pressure and returning the pulmonary system to a resting state. Elastic fibres are composite structures composed of a cross-linked elastin core and an outer layer of fibrillin microfibrils. These two components perform distinct roles; elastin stores energy and drives passive recoil, whilst fibrillin microfibrils direct elastogenesis, mediate cell signalling, maintain tissue homeostasis via TGFβ sequestration and potentially act to reinforce the elastic fibre. In many tissues reduced elasticity, as a result of compromised elastic fibre function, becomes increasingly prevalent with age and contributes significantly to the burden of human morbidity and mortality. This review considers how the unique molecular structure, tissue distribution and longevity of elastic fibres pre-disposes these abundant extracellular matrix structures to the accumulation of damage in ageing dermal, pulmonary and vascular tissues. As compromised elasticity is a common feature of ageing dynamic tissues, the development of strategies to prevent, limit or reverse this loss of function will play a key role in reducing age-related morbidity and mortality.

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Section: Cutaneousmentioning

confidence: 99%

Section: Cutaneousmentioning

confidence: 99%

Section: Cutaneousmentioning

confidence: 99%

See 1 more Smart Citation

Tissue elasticity and the ageing elastic fibre

Sherratt

2009

AGE

270

189

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“…Enfoque especial é dado às alterações que o envelhecimento provoca na pele, como a flacidez, o enrugamento, a desidratação e a perda de elasticidade cutânea. A importância da manutenção destas propriedades da pele provém da ação que esta exerce, por exemplo, quando exposta à traumas mecânicos, ou seja, fricção, impacto e pressão (Edwards, Marks, 1995;Diridollou et al, 1998;Fthenakis et al, 1991).…”

Section: Propriedades Mecânicas Da Peleunclassified

Aplicação de métodos de biofísica no estudo da eficácia de produtos dermocosméticos

Gonçalves

Campos

2009

Braz. J. Pharm. Sci.

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O trabalho aborda a aplicação dos métodos de biofísica no estudo de eficácia de produtos dermocosméticos. A qualidade de um produto cosmético engloba a segurança de seu uso, a estabilidade da formulação, o aspecto, o sensorial e a sua eficácia. As técnicas de biofísica têm sido amplamente empregadas na avaliação do efeito de formulações dermocosméticas, principalmente devido ao fato de possibilitarem a avaliação de produtos em suas reais condições de uso, ou seja, na pele humana. A comprovação dos efeitos de produtos cosméticos e a elucidação de seu mecanismo de ação por meio de protocolos experimentais devidamente elaborados, que utilizem as técnicas de biofísica da pele, dentre outras, tornam-se de fundamental importância e, assim, a serem amplamente exploradas e ainda bastante desenvolvidas, visando à melhoria da qualidade de vida dos usuários de tais produtos.Unitermos: Produtos dermocosméticos/controle de qualidade. Pele/biofísica/estudo. Biofísica/técnicas/ aplicação em cosmetologia. Cosméticos/eficácia.The authors consider the application of biophysical techniques in the study of cosmetics effectiveness. The quality of a cosmetic product includes the safety of its use, the formulation stability , the visual and other sensorial aspects, and its effectiveness. The biophysical techniques have been widely used in the evaluation of the effect of formulations of topical use, mainly due to the fact of facilitating the evaluation of products in its real use conditions, that is to say, directly in the human skin. The confirmation of the effects of cosmetic products and its action mechanism, by means of experimental protocols properly elaborated using the skin biophysics is of fundamental importance. It should be thoroughly explored and quite developed seeking the improvement of the life quality of users of such products. Uniterms:Dermocosmetic products/quality control. Skin/biophysics/study. Biophysics/techniques/ cosmetologic application. Cosmetics/effectiveness. INTRODUÇÃOO perfil de qualidade de um produto cosmético engloba eficácia e segurança de seu uso, a estabilidade da formulação e o aspecto sensorial. As técnicas de Biofísica da pele têm sido amplamente empregadas na avaliação do efeito de formulações de uso tópico, principalmente por possibilitar a avaliação de produtos em suas reais condições de uso, ou seja, diretamente na pele humana (Hadgraft, 2001; Dujardim et al., 2002;Reuther et al., 2007).A comprovação da eficácia destes produtos é de suma importância para o mercado consumidor, que deseja ver concretizado o apelo de venda que o impulsiona para o ato da compra. Desta maneira, novas metodologias de avaliação desta categoria de produto têm sido continuamente desenvolvidas, com ênfase na comprovação científica dos reais benefícios propostos por estas formulações.A constante pesquisa do tecido cutâneo e do emprego de metodologias não-invasivas tem dado origem a diferentes equipamentos para a avaliação dos efeitos dos produtos dermocosméticos

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“…Mechanical properties reported using these techniques vary widely. Values for simple parameters, such as the Young's modulus, have varied by over 3 orders of magnitude [19]. Variations in such estimates may arise from the choice of spatial and frequency ranges over which the skin is perturbed.…”

Section: Introductionmentioning

confidence: 99%

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

Parker

Jones

Hunter

et al. 2016

Journal of Biomechanical Engineering

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A triaxial force-sensitive microrobot was developed to dynamically perturb skin in multiple deformation modes, in vivo. Wiener static nonlinear identification was used to extract the linear dynamics and static nonlinearity of the force-displacement behavior of skin. Stochastic input forces were applied to the volar forearm and thenar eminence of the hand, producing probe tip perturbations in indentation and tangential extension. Wiener static nonlinear approaches reproduced the resulting displacements with variances accounted for (VAF) ranging 94-97%, indicating a good fit to the data. These approaches provided VAF improvements of 0.1-3.4% over linear models. Thenar eminence stiffness measures were approximately twice those measured on the forearm. Damping was shown to be significantly higher on the palm, whereas the perturbed mass typically was lower. Coefficients of variation (CVs) for nonlinear parameters were assessed within and across individuals. Individual CVs ranged from 2% to 11% for indentation and from 2% to 19% for extension. Stochastic perturbations with incrementally increasing mean amplitudes were applied to the same test areas. Differences between full-scale and incremental reduced-scale perturbations were investigated. Different incremental preloading schemes were investigated. However, no significant difference in parameters was found between different incremental preloading schemes. Incremental schemes provided depth-dependent estimates of stiffness and damping, ranging from 300 N/m and 2 Ns/m, respectively, at the surface to 5 kN/m and 50 Ns/m at greater depths. The device and techniques used in this research have potential applications in areas, such as evaluating skincare products, assessing skin hydration, or analyzing wound healing.

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An In Vivo Method for Measuring the Mechanical Properties of the Skin Using Ultrasound

Cited by 125 publications

References 32 publications

Tissue elasticity and the ageing elastic fibre

Tissue elasticity and the ageing elastic fibre

Aplicação de métodos de biofísica no estudo da eficácia de produtos dermocosméticos

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

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