An incidentally detected third ventricle chordoid glioma

Gallina, Pasquale; Pansini, Gastone; Mouchaty, H; Mura, Regina; Buccoliero, Anna Maria; Lorenzo, Nicola Di

doi:10.4103/0028-3886.33301

Cited by 17 publications

(11 citation statements)

References 5 publications

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“…[5, 7, 18, 37] Tumor immunopositivity for GFAP, EMA, CD34, cytokeratin, S100, and vimentin is commonly present. [5, 11, 38–40] Some degree of lymphocytic infiltrate appears to be common. Of the 57 cases that elaborated on extent of lymphocyte infiltration, 4 reported sparse infiltrate (7.0%).…”

Section: Resultsmentioning

confidence: 99%

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Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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Introduction Chordoid Gliomas (CG) are rare neoplasms which frequently arise within the third ventricle. Surgery remains the mainstay treatment for CG. The present study comprehensively reviews all reported cases of CG within the literature in order to identify risk factors for surgical complications and tumor recurrence. Methods A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science was conducted following PRISMA guidelines to identify all reported cases of CG. Results A total of 81 patients met the study criteria, comprised of 33 males and 48 females. Median age at diagnosis was 48 years with a range from 5 to 72 years, and mean tumor size was 3.1 cm. Biopsy, subtotal resection (STR), and gross total resection (GTR) was achieved in 8, 34, and 33 patients, respectively, with 6 cases not reporting extent of eresection (EOR). Thirteen patients underwent adjuvant radiotherapy. Postoperative complications were noted in 30 cases (37%), with new onset diabetes insipidus being the most common. Postoperative morbidity was not associated with age, tumor size, or extent of resection. A trans-lamina terminalis approach demonstrated a strong trend towards decreased overall rates of postoperative morbidity compared to other approaches (p=0.051). GTR was associated with improved progression-free survival (PFS; p=0.028), while adjuvant radiotherapy, age, tumor size and MIB-I were not predictive of patient outcomes. Conclusion GTR should be the primary goal for the management of CG, as it is associated with improved rates of tumor control without an increased rate of postoperative complications. Surgical approach was a stronger predictor of complication rates than extent of resection. Morbidity remains high, and future studies to further elaborate on factors predictive of postoperative complications are critical.

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Section: Resultsmentioning

confidence: 99%

“…The most common surgical approaches described to resect CG include transcallosal in 7 [12, 29, 37, 43, 44, 50], transcortical in 5 [22, 31, 51, 52], and trans-lamina terminalis in 17 [4, 11, 13, 17, 20, 23, 42, 43, 46, 47, 53–55]. Surgical approach was not specified in 52 patients.…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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“…Lymphoplasmacytic infiltrates and Russell bodies are often found in the tumor. 1,2,4,6,11,15,17,18,21,24,25,[27][28][29][30][32][33][34]36) Immunohistochemically, chordoid glioma is strongly and diffusely positive for GFAP and vimentin, and shows focal reactivity to EMA and cytokeratin in some cases, but little or no reactivity to S-100 protein. Some authors reported immunoreactivity for CD34, 4,12,15,17,18,21,24,25,27,28,30,31,[33][34][35][36] which will be useful for making differential diagnoses from chordoid meningioma, pilocytic astrocytoma, and/or ependymoma.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Kobayashi

Tsugawa

Hashizume

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Chordoid glioma of the third ventricle is considered to be a benign glial tumor located exclusively in the mid-anterior portion of the third ventricle near the hypothalamus and optic nerves, with the histological features of a chordoma and immuno-labeling for glial fibrillary acidic protein. Unfortunately, the clinical outcome of chordoid glioma has been poor, even in patients receiving gross total or partial removal with or without radiotherapy. Three cases of chordoid glioma of the third ventricle were treated with less invasive microsurgery for pathological diagnosis or partial removal without neuro-endocrinological complication, followed by gamma knife radiosurgery using a lower marginal dose for the optic nerves and hypothalamus. Gamma knife radiosurgery was performed after open biopsy in two patients, and after partial removal in the third patient using a lower marginal dose of 10.5 to 12 Gy. Serial magnetic resonance imaging revealed gradual decrease or at least no change in the tumor size, without significant complication at follow up 70 and 66 months later in two cases. The third patient accidentally died 13 months after gamma knife treatment. We conclude that low dose gamma knife radiosurgery after less invasive microsurgery is both safe and effective for the control of chordoid glioma of the third ventricle over a very long follow-up period.

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“…The clinical features are related to obstructive hydrocephalus due to a spaceoccupying lesion, producing symptoms such as lethargy, ataxia, urinary incontinence, vomiting, diabetes insipidus, and headache [2,9]. CG as an incidental finding has been reported as well [10].…”

Section: Gc Has Recently Been Included (2000) In the Cns Tumormentioning

confidence: 99%