An increase in the coronary calcification score is associated with an increased risk of heart failure in patients without a history of coronary artery disease

Sakuragi, Satoru; Ichikawa, Keishi; Yamada, Keiji; Tanimoto, Masafumi; Miki, Takashi; Otsuka, Hiroaki; Yamamoto, Kazuhiko; Kono, Kenji; Katayama, Yusuke; Tanakaya, Machiko; Ito, Hiroshi

doi:10.1016/j.jjcc.2015.06.014

Cited by 8 publications

(9 citation statements)

References 27 publications

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“…In our study, we showed that the association of CAC progression and HF remained statistically significant, even after excluding all participants with CHD. Our result is in agreement with a few previous studies that evaluated the association between baseline CAC and HF …”

Section: Discussionsupporting

confidence: 94%

“…Our result is in agreement with a few previous studies that evaluated the association between baseline CAC and HF. 14,15,17 Kalsch et al in the Heinz Nixdorf Recall Study has shown a significant association between CAC and history of HF in a univariate cross-sectional analysis. 14 This association became statistically insignificant after adjusting for traditional cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 95%

“…Sakuragi et al recently reported the result of a study on 487 Japanese participants free of CAD and HF at enrollment. 17 During the mean follow-up of 497AE315 days, 9 participants developed incident HF without any overt CHD. Higher CAC was associated with higher incidence of HF and higher NT-pro BNP level.…”

Section: Discussionmentioning

confidence: 99%

“…The investigators explained this diminished association by the fact that cardiovascular risk factors like hypertension can lead to both CAC formation and HF. Sakuragi et al recently reported the result of a study on 487 Japanese participants free of CAD and HF at enrollment . During the mean follow‐up of 497±315 days, 9 participants developed incident HF without any overt CHD.…”

Section: Discussionmentioning

confidence: 99%

“…11 CAC progression has a good predictive value for incident CHD and all-cause mortality. 12,13 Although the association between CAC and incident HF has been demonstrated in a few studies independent of CHD, [14][15][16][17] the value of CAC progression in prediction of future HF has not been previously evaluated. In this study, we investigate CAC progression as a predictor of incident HF and subclinical left ventricular (LV) dysfunction measured by CMR in a population-based cohort.…”

mentioning

confidence: 99%

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Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

Bakhshi

Ambale‐Venkatesh

Yang

et al. 2017

JAHA

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BackgroundAlthough the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated. In this study, we investigated the association of CAC progression with subclinical left ventricular (LV) dysfunction and incident HF in the Multi‐Ethnic Study of Atherosclerosis.Methods and ResultsThe Multi‐Ethnic Study of Atherosclerosis is a population‐based study consisting of 6814 men and women aged 45 to 84, free of overt cardiovascular disease at enrollment, who were recruited from 4 ethnicities. We included 5644 Multi‐Ethnic Study of Atherosclerosis participants who had baseline and follow‐up cardiac computed tomography and were free of HF and coronary heart disease before the second cardiac computed tomography. Mean (±SD) age was 61.7±10.2 years and 47.2% were male. The Cox proportional hazard models and multivariable linear regression models were deployed to determine the association of CAC progression with incident HF and subclinical LV dysfunction, respectively. Over a median follow‐up of 9.6 (interquartile range: 8.8–10.6) years, 182 participants developed incident HF. CAC progression of 10 units per year was associated with 3% of increased risk of HF independent of overt coronary heart disease (P=0.008). In 2818 participants with available cardiac magnetic resonance images, CAC progression was associated with increased LV end diastolic volume (β=0.16; P=0.03) and LV end systolic volume (β=0.12; P=0.006) after excluding participants with any coronary heart disease.Conclusions CAC progression was associated with incident HF and modestly increased LV end diastolic volume and LV end systolic volume at follow‐up exam independent of overt coronary heart disease.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

Bakhshi

Ambale‐Venkatesh

Yang

et al. 2017

JAHA

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Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study

et al. 2018

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To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60–79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained. Serum magnesium was inversely associated with many CVD risk factors including prevalent atrial fibrillation, lung function (FEV1) and markers of inflammation (IL-6), endothelial dysfunction (vWF) and cardiac dysfunction [NT-proBNP and cardiac troponin T (cTnT)]. Serum magnesium was inversely related to risk of incident HF after adjustment for conventional CVD risk factors and incident MI. The adjusted hazard ratios (HRs) for HF in the 5 quintiles of magnesium groups were 1.00, 0.72 (0.50, 1.05), 0.85 (0.59, 1.26), 0.76 (0.52, 1.11) and 0.56 (0.36, 0.86) respectively [p (trend) = 0.04]. Further adjustment for atrial fibrillation, IL-6, vWF and FEV1 attenuated the association but risk remained significantly reduced in the top quintile (≥ 0.87 mmol/l) compared with the lowest quintile [HR 0.62 (0.40, 0.97)]. Adjustment for NT-proBNP and cTnT attenuated the association further [HR 0.70 (0.44, 1.10)]. The benefit of high serum magnesium on HF risk was most evident in men with ECG evidence of ischaemia [HR 0.29 (0.13, 0.68)]. The potential beneficial effect of high serum magnesium was partially explained by its favourable association with CVD risk factors. Further studies are needed to investigate whether serum magnesium supplementation in older adults may protect from the development of HF.

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Role of Coronary Calcium Score to Identify Candidates for ASCVD Prevention

Nguyen

Liu

Castillo

et al. 2019

Curr Atheroscler Rep

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An increase in the coronary calcification score is associated with an increased risk of heart failure in patients without a history of coronary artery disease

Abstract: Severe CAC is an independent determinant of high NT-proBNP levels and a predictor of admission for HF in a population without a history of CAD or HF.

Cited by 8 publications

References 27 publications

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study

Role of Coronary Calcium Score to Identify Candidates for ASCVD Prevention

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