An indolinic cryptoalkaloid from Strychnos mattogrossensis

Angenot, Luc; Belem-Pinheiro, Maria-Lucia; Rocha, Arnaldo I. Da; Poukens-Renwart, Pascale; Quetin-Leclercq, Joëlle; Warin, R.

doi:10.1016/0031-9422(90)85240-g

Cited by 13 publications

(7 citation statements)

References 7 publications

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“…8) We can pose the question of whetter compound 1 has a role as a precursor in the biosynthesis of strychnine, 9) since 1 seems to be originated just before the formation of the Wieland-Gumlich aldehyde ( Fig. 2), but without hydroxylation at positions 3 and 18.…”

Section: 7)mentioning

confidence: 99%

Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice

Silva¹,

Rafacho²,

Hiruma-Lima³

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.

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Section: 7)mentioning

confidence: 99%

Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice

Silva¹,

Rafacho²,

Hiruma-Lima³

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The structure of 1 is the 3-hydroxy-enolate of the known alkaloid nordiidrofluorocurarine, previously isolated from S. amazonica and S. froessi. 8) We can pose the question of whetter compound 1 has a role as a precursor in the biosynthesis of strychnine, 9) since 1 seems to be originated just before the formation of the Wieland-Gumlich aldehyde (Fig. 2), but without hydroxylation at positions 3 and 18.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Strychnos pseudoquina St. Hil. Leaves Extract on Gastrointestinal Activity in Mice.

et al. 2005

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Alkaloids U 0600Evaluation of Strychnos pseudoquina St. Hil. Leaves Extract on Gastrointestinal Activity in Mice. -The new alkaloid (I) is isolated from the methanolic extract of leaves from S. pseudoquina together with rutin and kempferol 3-O-β-rutinoside. Both the polar and the enriched alkaloid fraction of the title plant reveal a significant anti-ulcer and cytoprotective effect on different induced gastric lesions with absence of toxicity by acute treatment. The anti-ulcer activity of the crude extract is almost as potent as that of the alkaloid-enriched fraction, thus indicating the possibility that further compounds may also contribute to the observed activity. -(APARECIDO DA SILVA, M.; MURINO RAFACHO, B. P.; HIRUMA-LIMA, C. A.; MACHADO DA ROCHA, L. R.; CAMPANER DOS SANTOS, L.; SANNOMIYA, M.; MONTEIRO SOUZA-BRITO, A. R.; VILEGAS*, W.; Chem. Pharm. Bull. 53 (2005) 8, 881-885;

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“…S. mattogrossensis is a South American species growing in the tropical forest of the Amazon. The root, stem bark and twigs of this plant have been investigated and it is known to contain alkaloids, such as mattogrossine, strychnobrasiline, 12-hydroxy-11-methoxystrychnobrasiline (Angenot et al, 1990), and more recently 12-hydroxy-10,11-dimethoxystrychnobrasiline (Belem-Pinheiro, Couceiro, Imbiriba da Rocha, Monte, & Villar, 2002).…”

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confidence: 99%

In vitro antiviral activity against SARS‐CoV‐2 of 28 Strychnos extracts

Ledoux

Leka

Bonnet

et al. 2022

Phytotherapy Research

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To the Editor, By the end of December 2019, an increasing number of patients diagnosed with pneumonia and respiratory failure of unknown origin in the Chinese city of Wuhan, lead to the discovery of the 2019 novel Coronavirus. Up to date, the therapy of the SARS-CoV-2 is limited to treat the symptoms and not to cure the Covid-19 disease (like Tamiflu for influenza), for this reason, the discovery of new antivirals is crucial.Natural products are an important source of antiviral compounds and therefore are extensively studied (Kim, 2021).Broad studies in our laboratory on Asian, African and Brazilian Strychnos species have been conducted, and have led to the isolation of numerous alkaloidic compounds. These plants have been evaluatedfor their antimalarial and cytotoxic potentials (Beaufay et al., 2018;

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An indolinic cryptoalkaloid from Strychnos mattogrossensis

Cited by 13 publications

References 7 publications

Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice

Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice

Evaluation of Strychnos pseudoquina St. Hil. Leaves Extract on Gastrointestinal Activity in Mice.

In vitro antiviral activity against SARS‐CoV‐2 of 28 Strychnos extracts

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