An Infant with Acute Brucellosis Presenting With Coombs-Positive Autoimmune Hemolytic Anemia: Is Breastfeeding Guilty for Transmission?

Apa, Hurşit; Keskin, Şükran; Gülfidan, Gamze; Yaman, Yontem; Devrim, İlker

doi:10.1089/vbz.2012.1154

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Human brucellosis has been associated with livestock contact, raw dairy food consumption and lack of access to health care (Bernard et al., ; Franco et al., ; Makita et al., ). There have also been instances of human‐to‐human transmission of brucellosis through breast milk of infected mothers to children (Palanduz et al., ; Apa et al., ) or through sexual intercourse (Kato et al., ). Human cases of brucellosis are tied to the disease in livestock, and reductions in brucellosis in livestock have resulted in reducing the number of human cases of the disease (Roth et al., ; Glynn and Lynn, ).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Brucellosis in Cattle, Goats and Humans in Rural Uganda: A Comparative Study

Miller¹,

Nakavuma

Ssajjakambwe

et al. 2015

Transbound Emerg Dis

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A cross-sectional study was conducted to determine the presence of brucellosis in cattle, goats and humans in farms from south-western Uganda and identify risk factors associated with brucellosis in these three host groups. Data and serum samples were collected from 768 cattle, 315 goats and 236 humans, with 635 samples of bovine milk, from 70 farms in two different study areas in south-western Uganda. Sera from livestock were tested with the Rose Bengal Plate test, using B. abortus and B. melitensis antigens, and human sera were tested with a commercial IgG/IgM lateral flow assay. Milk samples were tested using the OIE-approved milk ring test. Screening tests for brucellosis were positive in 14% of cattle serum, 29% of bovine milk, 17% of goat serum and 11% of human serum samples. There were significant differences in the test prevalence of brucellosis by study site, with levels higher in the study area near Lake Mburo National Park than in the study area near Queen Elizabeth National Park. Multivariable regression models identified risk factors associated with increasing test positivity at the individual and farm levels for cattle, goats and humans. Positive associations were seen between increasing seropositivity of brucellosis in goats, cattle and humans. Results of multivariable analyses suggest that improvements in farm biosecurity and hygiene may reduce the risk of brucellosis on the farm and suggest a role for ticks in bovine brucellosis. Although cattle are the focus of brucellosis control in Uganda, the significant associations between seropositivity in humans and seropositivity in goats suggest that brucellosis in goats may be an important contributor to the epidemiology of the disease on the farm.

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Section: Introductionmentioning

confidence: 99%

The Prevalence of Brucellosis in Cattle, Goats and Humans in Rural Uganda: A Comparative Study

Miller¹,

Nakavuma

Ssajjakambwe

et al. 2015

Transbound Emerg Dis

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“…Among reported forms of transmission we found breastfeeding and more exotic forms, such as bone marrow transplantation and aerosolization of the involved bacterium . In this review, 61% of patients were infants, reported as HHT by vertical transmission or during breastfeeding . Of the 47 patients, the transplacental route ranked as the most common form of HHT (with 11 total patients).…”

Section: Discussionmentioning

confidence: 87%

Human‐to‐human transmission of Brucella – a systematic review

Tuon

Gondolfo

Cerchiari

2017

Tropical Med Int Health

136

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Abstractobjective The most common form of transmitting human brucellosis is through contaminated food or direct contact with infected animals. Human-to-human transmission (HHT) has been described as isolated case reports. The aim of this systematic review was to describe all cases of HHT of human brucellosis reported in the medical literature.methods A literature search was conducted using PubMed, Scopus and Scielo databases using specific search terms published until March 2016. Two investigators independently determined study eligibility.All clinical data were evaluated to construct a table comprising the most important clinical aspects, age, gender, confirmed infection and detection method, transmission method and HHT confirmation and potential source of infection for human transmission. No statistical method was employed in this study.results The initial search resulted in 615 publications, but only 35 were included. 45 brucellosis HHT cases were identified. 61% of patients who acquired brucellosis from another human were <1 year old (newborn and breastfeeding). Other cases include sexual transmission, blood transfusion, bone marrow transplantation and aerosol from an infected patient. Most patients (40/45) presented symptoms upon diagnosis. Diagnostic tests included culture, molecular methods and serum testing.conclusion Human brucellosis is a disease liable to transmission between humans by placental barrier, lactation, sexual and tissues such as blood and bone marrow. The indication for screening in tissue banks, transplants, blood and pregnancy is not yet established.

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“…Breast milk is a potential source of infection, though it is frequently overlooked. [5] Clinical manifestations of childhood brucellosis are varied and range from minimal symptoms to extreme morbidity and occasional fatality. [6] Also, its clinical features are protean and simulate those of other febrile illnesses.…”

Section: Discussionmentioning

confidence: 99%

Childhood pneumonia due to brucellosis

et al. 2019

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Rationale: Childhood brucellosis is a significant community health problem. It may imitate other conditions and may be misdiagnosed. Pulmonary involvement is a rare complication of childhood brucellosis. Patient concerns: A 23-month-old child was referred to our hospital with a 3-week history of fevers and cough. He was initially diagnosed with pneumonia. Diagnoses and Interventions: Conventional antibiotic treatment was ineffectual. Total leukocyte count was 10,300/mm 3 , hemoglobin was 8.5 g/dL, and platelet count was 250,000/mm 3 . The erythrocyte sedimentation rate and procaicltonin were 25 mm/h and 0.12 ng/mL, respectively. Chest radiography showed pneumonic infiltrate in both lungs. The initial bacteriologic test results were negative. Ten days after admission, Brucella melitensis were isolated from the second blood culture. This child was cured with the 2-drug regimen (rifampin+trimethopicin-sulfamethoxazole) for 6 weeks. Outcomes: The child recovered well with no occurrence of complications. The child remained asmptomatic without any signs or symptoms at a follow-up of 1 year. Lessons: Non-specific findings of pulmonary brucellosis in children often make diagnosis difficult. The second blood culture is essential. In endemic areas, children with fevers and cough should be included in the diagnosis in cases of pulmonary brucellosis.

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An Infant with Acute Brucellosis Presenting With Coombs-Positive Autoimmune Hemolytic Anemia: Is Breastfeeding Guilty for Transmission?

Cited by 8 publications

References 27 publications

The Prevalence of Brucellosis in Cattle, Goats and Humans in Rural Uganda: A Comparative Study

The Prevalence of Brucellosis in Cattle, Goats and Humans in Rural Uganda: A Comparative Study

Human‐to‐human transmission of Brucella – a systematic review

Childhood pneumonia due to brucellosis

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