An injectable acellular matrix scaffold with absorbable permeable nanoparticles improves the therapeutic effects of docetaxel on glioblastoma

Xu, He‐Lin; Mao, Kaili; Lu, Cui-Tao; Fan, Zhihai; Yang, Jingjing; Xu, Jie; Chen, Pian-Pian; ZhuGe, De‐Li; Shen, Bi-Xin; Jin, Bing-Hui; Xiao, Jian; Zhao, Ying‐Zheng

doi:10.1016/j.biomaterials.2016.08.026

Cited by 44 publications

(56 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…100 For all the reasons given earlier, PTX and DTX are good candidates for nanovectorization even if, unlike DOX, they are not fluorescent molecules. To estimate their distribution in spheroids, Oregon Green PTX was used.…”

mentioning

confidence: 99%

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Millard¹,

Yakavets²,

Zorin³

et al. 2017

IJN

112

107

View full text Add to dashboard Cite

The increasing number of publications on the subject shows that nanomedicine is an attractive field for investigations aiming to considerably improve anticancer chemotherapy. Based on selective tumor targeting while sparing healthy tissue, carrier-mediated drug delivery has been expected to provide significant benefits to patients. However, despite reduced systemic toxicity, most nanodrugs approved for clinical use have been less effective than previously anticipated. The gap between experimental results and clinical outcomes demonstrates the necessity to perform comprehensive drug screening by using powerful preclinical models. In this context, in vitro three-dimensional models can provide key information on drug behavior inside the tumor tissue. The multicellular tumor spheroid (MCTS) model closely mimics a small avascular tumor with the presence of proliferative cells surrounding quiescent cells and a necrotic core. Oxygen, pH and nutrient gradients are similar to those of solid tumor. Furthermore, extracellular matrix (ECM) components and stromal cells can be embedded in the most sophisticated spheroid design. All these elements together with the physicochemical properties of nanoparticles (NPs) play a key role in drug transport, and therefore, the MCTS model is appropriate to assess the ability of NP to penetrate the tumor tissue. This review presents recent developments in MCTS models for a better comprehension of the interactions between NPs and tumor components that affect tumor drug delivery. MCTS is particularly suitable for the high-throughput screening of new nanodrugs.

show abstract

mentioning

confidence: 99%

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Millard¹,

Yakavets²,

Zorin³

et al. 2017

IJN

112

107

View full text Add to dashboard Cite

show abstract

“…Recently reported methods to make decellularize tissues are more likely to combine the physical, chemical or enzymatic strategies to achieve higher quality dECM scaffold/ biomaterials [11,[20][21][22][23][24][25][26]. We have previously prepared decellularized brain matrix by agitation in the following decellularization baths and completely removed the cellular components with entire brain structure [27,28]. Here, a similar method was adopted to decellularize the rabbit uterus.…”

Section: Discussionmentioning

confidence: 99%

Exploiting crosslinked decellularized matrix to achieve uterus regeneration and construction

Yao

Zheng

Lin

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

2020) Exploiting crosslinked decellularized matrix to achieve uterus regeneration and construction, Artificial Cells, Nanomedicine, and Biotechnology, 48:1, 218-229, ABSTRACTDecellularized extracellular matrix (dECM) has been considered as a promising scaffold in xenotransplantation, yet natural tissue dECM is often mechanically weak and rapidly degraded, compromising the outcomes. How to restore the mechanical strength and optimise the in vivo degradation, but maintain the microstructure and maximumly suppress the immune rejection, remains challenging. For this aim, we prepared and characterised various crosslinked decellularized rabbit uterus matrix (dUECM) and evaluated in vivo performance after uterus xenotransplantation from rabbit to rat. Naturally derived genipin (GP) and procyanidins (PC) were chosen to crosslink the dUECM, producing significant mechanical enhanced crosslinked-dUECM along with prolonged enzymatic degradation rate. Xenogeneic subcutaneous graft studies revealed that PC-and GP-crosslinked dUECM experienced significant cell infiltration and caused low immune reactions, indicating the desired biocompatibility. In vivo transplantation of GP-and PC-crosslinked dUECM to a uterus circular excised rat yielded excellent recellularization ability and promoted uterus regeneration after 90 days. While the reconstruction efficacy of crosslinked dUECM is highly depended on the crosslinking degree, crosslinking condition must be carefully evaluated to balance the role of crosslinked dECM in mechanical and biological support for tissue regeneration promotion. ARTICLE HISTORY

show abstract

“…Drug‐loaded scaffolds have been implanted in the glioblastoma resection cavity to increase chemotherapy outcome while providing a structure for resident NSC migration . Of interest to this work is the use of tissue engineering scaffolds for brain cavity reconstruction after surgery (Figure ).…”

Section: Tissue Engineering Scaffolds For Alzheimer’s and Parkinson'smentioning

confidence: 99%

Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients

et al. 2019

View full text Add to dashboard Cite

The world population is ageing at an alarming rate, currently increasing at around 3% per year for people over 60 years. This fast growing demography is largely unproductive and prone to many brain disorders such as Alzheimer's disease, Parkinson's disease, and brain tumors. Currently available treatment modalities are inadequate to stop neural degeneration or to completely eradicate cancer cells. Exogenously engineered scaffolds hold great potential for in vivo brain regeneration and functional restoration.

show abstract

An injectable acellular matrix scaffold with absorbable permeable nanoparticles improves the therapeutic effects of docetaxel on glioblastoma

Cited by 44 publications

References 41 publications

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Exploiting crosslinked decellularized matrix to achieve uterus regeneration and construction

Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients

Contact Info

Product

Resources

About